{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:12:05Z","timestamp":1778821925678,"version":"3.51.4"},"reference-count":124,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteoimmunology is an interdisciplinary field that investigates the interaction between the immune and skeletal systems in the context of immune regulation of bone remodeling. However, to date, osteoimmunology has not been linked to the broader systemic regulation of osteogenesis during physical exercise. Whole-body vibration (WBV) exercise initiates systemic sensory, endocrine, immune, and osteogenic responses. However, there is a gap in the understanding of the mechanisms underlying cross-system integration in WBV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our working hypothesis is that brain-immune modulation of osteogenesis in postmenopausal women with osteoporosis under the WBV conditions is regulated by the integrative proprioceptive endocrine pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and objects<\/jats:title>\n                    <jats:p>The postmenopausal women 65\u201367 years old with osteoporosis participated in the study. Methods are WBV, DEXA, laboratory methods for analyzing pro-osteogenic mediators, cellular and humoral immunity. Statistics is performed by StatPlus package; statistically significant changes in mean values \u200b\u200bat p &amp;lt; 0.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In postmenopausal women with osteoporosis under the 6-months WBV conditions the bone mineral density increased by 1.56% (p &amp;lt;0.05) and the peripheral blood lymphocyte subpopulations and serum humoral immunity was changed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The data obtained allow us, for the first time, to propose a hypothesis regarding brain-immune interaction in the regulation of osteogenesis in postmenopausal women with osteoporosis, the interface for which in cross-system interaction is the integrative proprioceptive endocrine pathway, which generally links the brain, the immune system and the bone remodeling during longitudinal WBV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1776499","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:28:15Z","timestamp":1778819295000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The endocrine pathway during whole body vibration modulates the immune system and the osteogenesis in postmenopausal women with osteoporosis"],"prefix":"10.3389","volume":"17","author":[{"given":"Vasiliy","family":"Pyatin","sequence":"first","affiliation":[{"name":"Neurointerfaces and Neurotechnologies Laboratory, Neurosciences Research Institute, Samara State Medical University","place":["Samara, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Maslova","sequence":"additional","affiliation":[{"name":"Science Department, Eurasian Technological University","place":["Almaty, Kazakhstan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102822","article-title":"Osteoimmunology and aging: Mechanisms, implications, and therapeutic perspectives","volume":"111","author":"Wang","year":"2025","journal-title":"Ageing Res Rev"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00060","article-title":"Physical activity and bone health: What is the role of immune system? 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