{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:09:39Z","timestamp":1791317379010,"version":"4.3.1"},"reference-count":117,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>PCOS is far more than an ovarian disorder; it is a systemic metabolic crisis affecting 11\u201313% of women. This review maps its extra-ovarian reach into the liver, heart, muscle, and pancreas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed how the \"pathophysiological quartet\"\u2014insulin resistance, hyperandrogenism, inflammation, and oxidative stress\u2014coordinates systemic damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PCOS prevalence skyrockets to 28.3% in women with obesity. Key findings include a 51.61% prevalence of MASLD in obese patients and a 2\u20134 fold increase in cardiovascular and type 2 diabetes risk. These manifestations are rooted in a shared metabolic \"soil,\" creating a vicious cycle of androgen excess and multi-organ dysfunction, including sarcopenia and \u03b2-cell exhaustion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fragmented care is insufficient. The systemic nature of PCOS demands a paradigm shift toward integrated, multidisciplinary management, treating the patient as a metabolic whole.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1776584","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:26:11Z","timestamp":1775795171000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of polycystic ovary syndrome on liver, heart, muscle, and pancreatic-related diseases"],"prefix":"10.3389","volume":"17","author":[{"given":"Bingrui","family":"Li","sequence":"first","affiliation":[{"name":"Basic Medicine School, Naval Medical University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Gynecology Department of Traditional Chinese Medicine, The First Affiliated Hospital of Naval Medical 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