{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:24:58Z","timestamp":1787117098779,"version":"build-2736575974"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>\u200bBackground<\/jats:title>\n                    <jats:p>\n                      Differentiation of unilateral from bilateral primary aldosteronism (PA) is crucial for identifying patients who are likely to be cured by adrenalectomy. This review evaluated the adrenal vein sampling (AVS)-referenced performance of\n                      <jats:sup>68<\/jats:sup>\n                      Ga-Pentixafor positron emission tomography\/computed tomography (PET\/CT) for detecting unilateral aldosterone-producing lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Web of Science, and Embase for relevant articles published up to May 2025. This review followed a prespecified population, index test, comparator, outcome, and study design (PICOS) framework. Using Meta-DiSc v.1.4 and Stata software, sensitivity, specificity, likelihood ratios, and diagnostic odds ratios were pooled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve studies met the inclusion criteria. Hu et\u00a0al., 2023 was retained only for qualitative description and excluded from the primary quantitative synthesis because of its clear outlying influence; thus, 11 studies were included in the main pooled synthesis. The pooled sensitivity and specificity were 0.75 (95% CI: 0.67\u20130.82) and 0.81 (95% CI: 0.74\u20130.87), respectively. The positive and negative likelihood ratios were 4.05 and 0.31, respectively. The diagnostic odds ratio (DOR) was 12.59 (95% CI: 7.21\u201322.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:sup>68<\/jats:sup>\n                      Ga-Pentixafor PET\/CT showed fair concordance with AVS-based lateralization and may have a role as an adjunctive test in selected clinical scenarios, especially when AVS is unavailable, non-diagnostic, or technically demanding. Further prospective trials with validation against postoperative biochemical and clinical outcomes are warranted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251067457<\/jats:ext-link>\n                      , identifier CRD420251067457.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1777128","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:37:25Z","timestamp":1787114245000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["AVS-referenced diagnostic performance of 68Ga-Pentixafor PET\/CT for detecting unilateral disease in primary aldosteronism: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Junjie","family":"Su","sequence":"first","affiliation":[{"name":"Department of Urology, First Hospital of Jilin University, Chaoyang District","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changliang","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Urology, First Hospital of Jilin University, Chaoyang District","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaikang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, First Hospital of Jilin University, Chaoyang District","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Urology, First Hospital of Jilin University, Chaoyang District","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Urology, First Hospital of Jilin University, Chaoyang District","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, First Hospital of Jilin University, Chaoyang District","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Urology, First Hospital of Jilin University, Chaoyang District","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Urology, First Hospital of Jilin University, Chaoyang District","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, First Hospital of Jilin University, Chaoyang District","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-5-200909010-00007","article-title":"Systematic review: diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism","volume":"151","author":"Kempers","year":"2009","journal-title":"Ann Intern Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/s2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and 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