{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:55:00Z","timestamp":1781499300984,"version":"3.54.1"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to systematically assess perioperative clinical safety, medium-term weight loss outcomes, multidisciplinary management challenges, and the clinical applicability of laparoscopic sleeve gastrectomy (LSG) in adults with Prader-Willi syndrome (PWS) and super-morbid obesity (body mass index [BMI] \u2265 50 kg\/m\u00b2), with the objective of identifying appropriate candidates for surgical intervention and establishing standardized perioperative management strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 24-year-old male with PWS and super-morbid obesity (BMI: 64.44 kg\/m\u00b2) underwent LSG following comprehensive multidisciplinary team (MDT) evaluation. Short-term postoperative recovery was uneventful; however, long-term weight reduction outcomes and the risk of postoperative complications remained uncertain. A review of the literature suggested that although LSG was associated with modest weight reduction in patients with PWS, significant postoperative management challenges remained, including behavioral issues, nutritional monitoring requirements, and the need for long-term multidisciplinary support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LSG should not be considered a first-line intervention for patients with PWS. Surgical intervention should be restricted to carefully selected patients following comprehensive MDT evaluation. Optimized perioperative behavioral management, together with emerging pharmacological therapies and non-invasive ventilatory support, may expand surgical eligibility within this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1781163","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:27:06Z","timestamp":1781497626000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Laparoscopic sleeve gastrectomy in adults with Prader-Willi syndrome and super-morbid obesity: a case report and literature review"],"prefix":"10.3389","volume":"17","author":[{"given":"Ji","family":"Li","sequence":"first","affiliation":[{"name":"Department of pharmaceutical preparation section, Qilu Hospital of Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhua","family":"Hao","sequence":"additional","affiliation":[{"name":"Research Center for Coastal Zone Science and Marine Development Strategy, First Institute of Oceanography, Ministry of Natural Resources","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qilu Hospital of Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qilu Hospital of Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1542\/peds.91.2.398","article-title":"Prader-Willi syndrome: consensus diagnostic criteria","volume":"91","author":"Holm","year":"1993","journal-title":"Pediatrics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1053\/j.sempedsurg.2013.10.013","article-title":"Bariatric surgery in monogenic and syndromic forms of obesity","volume":"23","author":"Alqahtani","year":"2014","journal-title":"Semin Pediatr Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0649","article-title":"Recommendations for the diagnosis and management of Prader-Willi syndrome","volume":"93","author":"Goldstone","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.3654","article-title":"The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012","volume":"149","author":"Chang","year":"2014","journal-title":"JAMA Surg"},{"key":"B5","article-title":"Classification of obesity","volume":"7","author":"Deitel","year":"1997","journal-title":"Obes Surg"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000239086.30518.2a","article-title":"Duodenal switch provides superior weight loss in the super-obese (BMI \u226550 kg\/m\u00b2) compared with gastric bypass","volume":"244","author":"Prachand","year":"2006","journal-title":"Ann Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.118","article-title":"Neural mechanisms underlying hyperphagia in Prader-Willi syndrome","volume":"14","author":"Holsen","year":"2006","journal-title":"Obes (Silv Spri)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31507","article-title":"Energy expenditure and physical activity in Prader-Willi syndrome: comparison with obese subjects","author":"Butler","year":"2007","journal-title":"Am J Med Genet A"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2147\/ndt.s5560","article-title":"Clinical management of behavioral characteristics of Prader-Willi syndrome","volume":"6","author":"Ho","year":"2010","journal-title":"Neuropsychiatr Dis Treat"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23385","article-title":"Critical review of bariatric surgical outcomes in patients with Prader-Willi syndrome and other hyperphagic disorders","volume":"30","author":"Gantz","year":"2022","journal-title":"Obes (Silv Spri)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.56591","article-title":"Complex cardiovascular morbidities in Prader-Willi syndrome: a multidisciplinary approach","volume":"16","author":"Alba","year":"2024","journal-title":"Cureus"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-022-00909-7","article-title":"Autonomic nervous system dysfunction in Prader-Willi syndrome","volume":"33","author":"Butler","year":"2023","journal-title":"Clin Auton Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.27955","article-title":"Effects of restrictive bariatric surgery on congenital Prader-Willi syndrome: a case report","volume":"14","author":"Soomro","year":"2022","journal-title":"Cureus"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-012-0725-x","article-title":"Ghrelin level and weight loss after laparoscopic sleeve gastrectomy and gastric mini-bypass for Prader-Willi syndrome in Chinese","volume":"22","author":"Fong","year":"2012","journal-title":"Obes Surg"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2023.01.017","article-title":"Metabolic and bariatric surgery for obesity in Prader Willi syndrome: systematic review and meta-analysis","volume":"19","author":"Wolfe","year":"2023","journal-title":"Surg Obes Relat Dis"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14120833","article-title":"MC-LR aggravates liver lipid metabolism disorders in obese mice fed a high-fat diet via PI3K\/AKT\/mTOR\/SREBP1 signaling pathway","volume":"14","author":"Chu","year":"2022","journal-title":"Tox (Basel)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1381\/096089296765557286","article-title":"Biliopancreatic diversion in Prader-Willi syndrome associated with obesity","volume":"6","author":"Antal","year":"1996","journal-title":"Obes Surg"},{"key":"B18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.17476\/jmbs.2025.14.2.85","article-title":"Bariatric surgery in patients with Prader-Willi syndrome","volume":"14","author":"Dressler","year":"2025","journal-title":"J Metab Bariatr Surg"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19569","article-title":"Association of bariatric surgery with major adverse liver and cardiovascular outcomes in patients with biopsy-proven nonalcoholic steatohepatitis","volume":"326","author":"Aminian","year":"2021","journal-title":"JAMA"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.36922\/bh.2190","article-title":"Patent foramen ovale closure in a patient with extensive lipomatous hypertrophy of the septum secundum: a case report","volume":"2","author":"Terekhin","year":"2024","journal-title":"Brain Heart"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12575","article-title":"Bariatric surgery for Prader-Willi syndrome was ineffective in producing sustainable weight loss: long term results for up to 10 years","volume":"15","author":"Liu","year":"2020","journal-title":"Pediatr Obes"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2015.07.014","article-title":"Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study","volume":"12","author":"Alqahtani","year":"2016","journal-title":"Surg Obes Relat Dis"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1381\/096089201321209404","article-title":"Outcome of biliopancreatic diversion in subjects with Prader-Willi syndrome","volume":"11","author":"Marinari","year":"2001","journal-title":"Obes Surg"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.901559","article-title":"Effects of GLP-1 receptor agonists on biological behavior of colorectal cancer cells by regulating PI3K\/AKT\/mTOR signaling pathway","volume":"13","author":"Tong","year":"2022","journal-title":"Front Pharmacol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2024.2396387","article-title":"Clinical features, treatment, and prognosis of SGLT2 inhibitors induced acute pancreatitis","volume":"24","author":"Li","year":"2025","journal-title":"Expert Opin Drug Saf"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2025.107563","article-title":"Amylin receptors as therapeutic targets in obesity: emerging peptide-based strategies","volume":"162","author":"Rejili","year":"2026","journal-title":"Vascul Pharmacol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2026.156457","article-title":"ROS-associated metabolic disorders: molecular mechanism and stem cell therapy","volume":"282","author":"Debnath","year":"2026","journal-title":"Pathol Res Pract"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2014.11.202","article-title":"Adverse effects of GLP-1 receptor agonists","volume":"11","author":"Filippatos","year":"2014","journal-title":"Rev Diabetes Stud"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-021-05284-2","article-title":"Changes in anthropometric measures, nutritional indices and gastrointestinal symptoms following one anastomosis gastric bypass (OAGB) compared with Roux-en-y gastric bypass (RYGB)","volume":"31","author":"Zarshenas","year":"2021","journal-title":"Obes Surg"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156796","article-title":"Precision strike strategy for liver diseases trilogy with Xiao-Chai-Hu decoction: a meta-analysis with machine learning","volume":"142","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.2147\/AHMT.S214893","article-title":"Dietary management for adolescents with Prader-Willi syndrome","volume":"11","author":"Miller","year":"2020","journal-title":"Adolesc Health Med Ther"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/CEG.S461534","article-title":"Managing leaks and fistulas after laparoscopic sleeve gastrectomy: challenges and solutions","volume":"18","author":"Gipe","year":"2025","journal-title":"Clin Exp Gastroenterol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33951","article-title":"Nutritional phases in Prader-Willi syndrome","author":"Miller","year":"2011","journal-title":"Am J Med Genet A"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.178","article-title":"Causes of death in Prader-Willi syndrome: Prader-Willi Syndrome Association (USA) 40-year mortality survey","volume":"19","author":"Butler","year":"2017","journal-title":"Genet Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1542\/peds.2010-2820","article-title":"Clinical report\u2014health supervision for children with Prader-Willi syndrome","volume":"127","author":"McCandless","year":"2011","journal-title":"Pediatrics"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-020-04708-9","article-title":"Prader-Willi syndrome: role of bariatric surgery in two adolescents with obesity","volume":"30","author":"Tripodi","year":"2020","journal-title":"Obes Surg"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32133","article-title":"The Italian National Survey for Prader-Willi syndrome: an epidemiologic study","author":"Grugni","year":"2008","journal-title":"Am J Med Genet A"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.2174\/1573396315666190716120925","article-title":"Prader-Willi syndrome - clinical genetics, diagnosis and treatment approaches: an update","volume":"15","author":"Butler","year":"2019","journal-title":"Curr Pediatr Rev"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1381\/0960892054222885","article-title":"Results of biliopancreatic diversion in two patients with Prader-Willi syndrome","volume":"15","author":"de Almeida","year":"2005","journal-title":"Obes Surg"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-3283-z","article-title":"Obesity management task force of the european association for the study of obesity released \"Practical recommendations for the post-bariatric surgery medical management","volume":"28","author":"Busetto","year":"2018","journal-title":"Obes Surg"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12792","article-title":"Current and emerging therapies for managing hyperphagia and obesity in Prader-Willi syndrome","volume":"21","author":"Tan","year":"2020","journal-title":"Pediatr Obes"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00277-7","article-title":"Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alstr\u00f6m syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period","volume":"10","author":"Haqq","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-015-0312-9","article-title":"Prader-Willi syndrome: a review of clinical, genetic, and endocrine findings","volume":"38","author":"Angulo","year":"2015","journal-title":"J Endocrinol Invest"},{"key":"B44","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/jcpp.12601","article-title":"Cognitive and adaptive advantages of growth hormone treatment in children with Prader-Willi syndrome","volume":"58","author":"Dykens","year":"2017","journal-title":"J Child Psychol Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2012","article-title":"Eight years of growth hormone treatment in children with Prader-Willi syndrome: maintaining the positive effects","volume":"98","author":"Bakker","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000304458.30294.31","article-title":"Critical analysis of bariatric procedures in Prader-Willi syndrome","volume":"46","author":"Scheimann","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1781163\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:27:13Z","timestamp":1781497633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1781163\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":46,"alternative-id":["10.3389\/fendo.2026.1781163"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1781163","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"article-number":"1781163"}}