{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:18:28Z","timestamp":1771395508549,"version":"3.50.1"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Ectopic intravagal parathyroid adenomas represent an exceedingly rare clinical entity. Embryologically, parathyroid glands develop from the third and fourth pharyngeal pouches, migrating to their definitive locations on the inferior and superior aspects of the thyroid. While ectopic locations are well described, intravagal variants are rare, with few documented cases in the literature. We report an additional unique case of a patient with persistent hypercalcemia and severe osteoporosis following a failed bilateral neck exploration for primary hyperparathyroidism. Following multimodal structural and functional radiological evaluation, an ectopically undescended parathyroid adenoma was identified and subsequently confirmed intraoperatively to be situated intravagal.<\/jats:p>","DOI":"10.3389\/fendo.2026.1783095","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:33:55Z","timestamp":1771392835000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: An undescended intravagal parathyroid adenoma: a rare cause of refractory primary hyperparathyroidism and severe osteoporosis"],"prefix":"10.3389","volume":"17","author":[{"given":"Hassan A.","family":"Alzahrani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/00000658-197603000-00010","article-title":"The anatomic basis of parathyroid surgery","volume":"183","author":"Wang","year":"1976","journal-title":"Ann surgery."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010173","article-title":"Surgeon\u2019s approach to the thyroid gland: surgical anatomy and the importance of technique","volume":"24","author":"Bliss","year":"2000","journal-title":"World J surgery."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2855","article-title":"Intravagal parathyroid adenomas: Case report and literature review","volume":"8","author":"List","year":"2020","journal-title":"Clin Case Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1996.01430200071013","article-title":"Reoperation for persistent or recurrent primary hyperparathyroidism","volume":"131","author":"Shen","year":"1996","journal-title":"Arch Surgery."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s002680020067","article-title":"Identification and management of intravagal parathyroid adenoma","volume":"25","author":"Pawlik","year":"2001","journal-title":"World J surgery."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac024","article-title":"An approach to a patient with primary hyperparathyroidism and a suspected ectopic parathyroid adenoma","volume":"107","author":"Glasgow","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"B7","doi-asserted-by":"publisher","first-page":"101721","DOI":"10.1016\/j.ando.2025.101721","article-title":"Management of primary hyperparathyroidism in MEN1: From initial subtotal surgery to complex treatment of the remaining gland","volume":"86","author":"Schubert","year":"2025","journal-title":"Ann Endocrinol (Paris)."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411701","article-title":"A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery","volume":"341","author":"Silverberg","year":"1999","journal-title":"New Engl J Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.4249","article-title":"Long-term quality of life after parathyroidectomy for primary hyperparathyroidism: a systematic review","volume":"157","author":"Livschitz","year":"2022","journal-title":"JAMA surgery."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181d76bb3","article-title":"Parathyroidectomy improves functional capacity in \u201casymptomatic\u201d older patients with primary hyperparathyroidism: a randomized control trial","volume":"251","author":"Morris","year":"2010","journal-title":"Ann Surg"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1783095\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:33:56Z","timestamp":1771392836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1783095\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":10,"alternative-id":["10.3389\/fendo.2026.1783095"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1783095","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"article-number":"1783095"}}