{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:40:05Z","timestamp":1772692805828,"version":"3.50.1"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to develop a non-invasive diagnostic model to differentiate diabetic kidney disease (DKD) from non-diabetic kidney disease (NDKD) in type 2 diabetes mellitus (T2DM) patients with renal insufficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, biopsy-based study of diabetic patients with kidney dysfunction between July 2018 and August 2023. Patients were randomly split into training and validation cohorts (7:3). A multivariable logistic regression model based on routinely available, non-invasive clinical variables was developed and internally validated. Discrimination and calibration were evaluated in both cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 507 patients were enrolled: 171 with DKD, 260 with NDKD, and 76 with concurrent DKD and NDKD. A five-variable model incorporating diabetes duration, diabetic retinopathy, systolic blood pressure, fasting plasma glucose, and hemoglobin levels demonstrated good discrimination and acceptable calibration in both datasets. Decision curve analysis suggested the model\u2019s potential clinical utility. The model was presented as a nomogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This nomogram may support non-invasive differential diagnosis between DKD and NDKD in T2DM patients with kidney injury, thereby informing clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1787412","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:25:15Z","timestamp":1772688315000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and validation of a multivariable prediction model for non-invasive discrimination between diabetic and non-diabetic kidney disease in type 2 diabetes: a clinical nomogram"],"prefix":"10.3389","volume":"17","author":[{"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuzhe","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaonan","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojie","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonggao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7111a3","article-title":"Reported cases of end-stage kidney disease - United States, 2000-2019","volume":"71","author":"Burrows","year":"2022","journal-title":"MMWR Morb Mortal Wkly 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