{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:48:15Z","timestamp":1777265295445,"version":"3.51.4"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore whether central lymph node ratio (LNR) can be used to predict the lateral lymph node metastasis (LLNM) in pediatric patients with differentiated thyroid carcinoma (DTC) and construct a predictive model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed the clinicopathological data of patients with DTC (aged \u226414 years) who had thyroid lobectomy (unilateral or bilateral)and therapeutic central neck dissection (CND) with concurrent or staged lateral neck dissection (LND) from 2015 to 2025. Patients were grouped by LLNM status. Receiver Operating Characteristic Curve (ROC) analysis identified the optimal LNR cutoff.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In univariate analysis, central LNR threshold of 0.4 predicts LLNM with a sensitivity of 90.0%, specificity of 76.0%, and OR of 11.374.Multivariate analysis identified central LNR (OR\u00a0=\u00a03.741), bilaterality (OR=3.850), and \u22654 metastatic central nodes (OR\u00a0=\u00a04.732) as independent predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Central LNR, bilaterality, and \u22654 metastatic central lymph nodes were independent predictors. An LNR \u22650.4 serves as a key indicator for identifying high-risk pediatric DTC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1787834","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:27:58Z","timestamp":1777264078000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Central lymph node ratio predicting lateral metastasis in pediatric thyroid cancer: a retrospective study"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiaoming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University","place":["Zhengzhou, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou 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