{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:06:22Z","timestamp":1792551982540,"version":"4.5.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The triglyceride-glucose index (TyG) and its derivatives, such as the TyG-waist-to-height ratio (TyG-WHtR), provide reliable surrogate measures for estimating insulin resistance (IR). Their associations with renal function in hypertensive patients remain unclear. This study examined the associations of TyG-WHtR and its related indices with estimated glomerular filtration rate (eGFR) in a community-based elderly hypertensive population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study assessed the clinical indicators, TyG-related indices, and eGFR in a cohort of 3,764 hypertensive adults aged \u226565 years from Huaian, China, employing restricted cubic spline models (RCS), logistic regression, spearman correlation, and receiver operating characteristic (ROC) curve analyses to evaluate the associations and predictive utility of TyG-WHtR and related parameters for identifying impaired renal function, defined by reduced eGFR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 612 participants (16.25%) had reduced eGFR. Significant predictors of reduced eGFR included elevated TyG-WHtR and related indices, with TyG-WHtR showing a particularly robust association in both pre- and post-adjustment analyses. These indices correlated negatively with high-density lipoprotein cholesterol (HDL-C), and positively with measures of adiposity, fasting plasma glucose (FPG), and non-HDL cholesterol. Significant interactions were found for gender, age, and alcohol consumption. TyG-WHtR alone had an AUC of 0.596, but after adjustment its predictive ability improved to 0.864, demonstrating superior performance compared to TyG, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated TyG-WHtR is an independent risk factor for the decline in eGFR in elderly patients with hypertension, demonstrating superior predictive value compared to other TyG-related indices. TyG-WHtR may serve as a useful marker for early identification of renal dysfunction in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1789763","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:28:20Z","timestamp":1781497700000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The triglyceride-glucose\u2013waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiaying","family":"Ling","sequence":"first","affiliation":[{"name":"Department of General Practice, The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University","place":["Huaian, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of General 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