{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:28:47Z","timestamp":1788866927869,"version":"build-2803163510"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) infects more than 50% of the global population and is associated with a variety of upper gastrointestinal diseases. In recent years, studies have suggested that\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection may contribute to metabolic syndrome and dyslipidemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate the association between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and serum lipid levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 678 participants who underwent both the\n                      <jats:sup>13<\/jats:sup>\n                      C-urea breath test and a lipid profile test at our hospital in 2024. We collected demographic and clinical characteristics, breath test results, and serum lipid profiles.\n                      <jats:italic>H. pylori<\/jats:italic>\n                      positivity was defined as a DOB value \u2265 4\u2030. We performed 1:1 propensity score matching (PSM) on key covariates (sex, age, and body mass index [BMI]), yielding 214\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -positive participants and 214\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -negative participants. We compared serum lipid levels between the two matched groups. We used paired fixed-effects linear regression to evaluate the independent association between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and triglyceride (TG) levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Triglyceride (TG) levels remained higher in the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -positive group. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) did not differ significantly between the two groups. In the adjusted model controlling for age, sex, smoking, alcohol use, hypertension, and diabetes,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was independently associated with higher TG levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection is independently associated with elevated triglyceride levels. These findings highlight the potential role of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      in metabolic risk assessment and in the design of intervention studies. The causal relationship requires further confirmation in prospective and mechanistic studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1792530","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:02:36Z","timestamp":1774418556000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Helicobacter pylori infection is independently associated with triglyceride levels: a propensity score\u2013matched cross-sectional study"],"prefix":"10.3389","volume":"17","author":[{"given":"Yu","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Xuancheng People\u2019s Hospital, Affiliated Xuancheng Hospital Wannan Medical College","place":["Xuancheng, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Huai\u2019an No.3 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Xuancheng People\u2019s Hospital, Affiliated Xuancheng Hospital Wannan Medical College","place":["Xuancheng, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoxing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Xuancheng People\u2019s Hospital, Affiliated Xuancheng Hospital Wannan Medical College","place":["Xuancheng, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06529-0","article-title":"Novel insights into the pathological mechanisms of metabolic related dyslipidemia","volume":"48","author":"Su","year":"2021","journal-title":"Mol Biol 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