{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:50:12Z","timestamp":1772621412361,"version":"3.50.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gestational diabetes mellitus (GDM) remains a major obstetric concern, yet the optimal screening strategy and the prognostic value of oral glucose tolerance test (OGTT) parameters remain debated. We aimed to compare the diagnostic yield and clinical outcomes of a two-step OGTT strategy (50 g glucose challenge followed by 100 g OGTT) versus a one-step 75 g OGTT approach, and to evaluate the predictive performance of individual OGTT time points for pregnancy complications and treatment requirement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective randomized controlled trial, 1,439 pregnant women undergoing routine screening at 24\u201328 weeks of gestation were randomized to either a two-step OGTT strategy (n=719) or a one-step 75 g OGTT strategy (n=720). GDM was classified as diet-controlled or insulin-requiring. Maternal risk factors, obstetric outcomes, and neonatal outcomes were recorded. Receiver operating characteristic (ROC) analyses assessed the predictive ability of OGTT parameters for polyhydramnios and insulin requirement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall GDM prevalence was 12.3%, including 8.4% diet-controlled and 3.9% insulin-requiring cases. The one-step strategy identified a numerically higher proportion of GDM without significant differences in maternal or neonatal outcomes compared with the two-step approach. Rates of polyhydramnios, hypertensive disorders, macrosomia, cesarean delivery, preterm birth, neonatal intensive care admission, small for gestational age (7.4%), and intrauterine growth restriction (4.2%) were comparable between groups. ROC analyses demonstrated that 2-hour OGTT values showed the strongest predictive performance for polyhydramnios (AUC up to 0.816) and insulin requirement (AUC up to 0.808), whereas the 50 g screening test showed only moderate discrimination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The one-step 75 g OGTT increases diagnostic labeling without improving short-term clinical outcomes. Post-load OGTT values\u2014particularly 2-hour glucose levels\u2014provide the most clinically meaningful prognostic information and may support a risk-stratified approach to GDM management rather than expansion of diagnostic thresholds alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1793806","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:43:16Z","timestamp":1772602996000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive value of OGTT parameters and clinical markers in gestational diabetes mellitus: a prospective randomized controlled trial from a tertiary center in T\u00fcrkiye"],"prefix":"10.3389","volume":"17","author":[{"given":"Batuhan","family":"Turgay","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, T\u00fcrkiye. Reproductive Health Diagnosis Treatment Education Research and Application Center, Ankara University","place":["Ankara, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U\u011furcan","family":"Zorlu","sequence":"additional","affiliation":[{"name":"Perinatology Unit, Ankara Bilkent City Hospital","place":["Ankara, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harun","family":"K\u0131l\u0131\u00e7k\u0131ran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, D\u00f6rtyol State Hospital","place":["Hatay, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayra","family":"Turgay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gazi University","place":["Ankara, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl\u015fah","family":"Aynao\u011flu Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Perinatology Unit, Ankara University Faculty of Medicine","place":["Ankara, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif G\u00fcl","family":"Yapar Eyi","sequence":"additional","affiliation":[{"name":"Perinatology Unit, Ankara Bilkent City Hospital","place":["Ankara, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Seval","family":"Ozgu-Erdinc","sequence":"additional","affiliation":[{"name":"Perinatology Unit, Ankara Bilkent City Hospital","place":["Ankara, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2337\/dc26-S015","article-title":"Management of diabetes in pregnancy: Standards of Care in Diabetes\u20142026","volume":"49","year":"2026","journal-title":"Diabetes Care"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002501","article-title":"ACOG Practice Bulletin No. 190: Gestational diabetes mellitus","volume":"131","year":"2018","journal-title":"Obstet Gynecol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848","article-title":"Recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","year":"2010","journal-title":"Diabetes 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