{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:59:48Z","timestamp":1772517588880,"version":"3.50.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2026.1806508","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:22:27Z","timestamp":1772515347000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Editorial: Mechanistic, machine learning and hybrid models of the \u2018other\u2019 endocrine regulatory systems in health and disease, volume II"],"prefix":"10.3389","volume":"17","author":[{"suffix":"III","given":"Joseph","family":"DiStefano","sequence":"first","affiliation":[{"name":"Departments of Computer Science and Medicine, University of California at Los Angeles","place":["Los Angeles, CA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes W.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Metabolism Section, Department of Internal Medicine I, St. Josef University Hospital, Ruhr University Bochum","place":["Bochum, Germany"]},{"name":"Diabetes Centre Bochum\/Hattingen, Klinik Blankenstein","place":["Hattingen, Germany"]},{"name":"Centre for Rare Endocrine Diseases, Ruhr Centre for Rare Diseases (CeSER), Ruhr University Bochum and Witten\/Herdecke University","place":["Bochum, Germany"]},{"name":"Centre for Diabetes Technology, Catholic Hospitals Bochum, Ruhr University Bochum","place":["Bochum, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Alon","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.583016","article-title":"Origins and history of the minimal model of glucose regulation","volume":"11","author":"Bergman","year":"2021","journal-title":"Front Endocrinol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231195081","article-title":"Developing the UVA\/padova type 1 diabetes simulator: modeling, validation, refinements, and utility","volume":"17","author":"Cobelli","year":"2023","journal-title":"J Diabetes Sci Technol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"17659","DOI":"10.1038\/s41598-022-22531-3","article-title":"SPINA Carb: a simple mathematical model supporting fast in-vivo estimation of insulin sensitivity and beta cell function","volume":"12","author":"Dietrich","year":"2022","journal-title":"Sci Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e13525","DOI":"10.1111\/1753-0407.13525","article-title":"A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis","volume":"16","author":"Dietrich","year":"2024","journal-title":"J Diabetes"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/19322968211008442","article-title":"Algorithms for automated insulin delivery: an overview","volume":"16","author":"Thomas","year":"2021","journal-title":"J\u00a0Diabetes Sci Technol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3923\/jas.2014.1465.1468","article-title":"A review of mathematical model describing insulin delivery system for type 1 diabetes","volume":"14","author":"Mohd Yusof","year":"2014","journal-title":"J Appl Sci"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/193229680900300223","article-title":"Mathematical modeling research to support the development of automated insulin-delivery systems","volume":"3","author":"Steil","year":"2009","journal-title":"J Diabetes Sci Technol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1365-2362.2008.02060.x","article-title":"The serum sodium to urinary sodium to (serum potassium)2 to urinary potassium (SUSPPUP) ratio in patients with primary aldosteronism","volume":"39","author":"Willenberg","year":"2009","journal-title":"Eur J Clin Invest"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2016.00057","article-title":"Calculated parameters of thyroid homeostasis: emerging tools for differential diagnosis and clinical research","volume":"7","author":"Dietrich","year":"2016","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e9510","DOI":"10.15252\/msb.20209510","article-title":"A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks","volume":"16","author":"Karin","year":"2020","journal-title":"Mol Syst Biol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"11017","DOI":"10.1038\/s41467-025-65924-4","article-title":"Unifying regulatory motifs in endocrine circuits","volume":"16","author":"Raz","year":"2025","journal-title":"Nat Commun"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1104746","article-title":"Editorial: Mechanistic, machine learning and hybrid models of the \u201cother\u201d endocrine regulatory systems in health & disease","volume":"14","author":"DiStefano","year":"2023","journal-title":"Front Endocrinol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"18412","DOI":"10.1038\/s41598-022-22025-2","article-title":"Association between metabolic syndrome and uric acid: a systematic review and meta-analysis","volume":"12","author":"Raya-Cano","year":"2022","journal-title":"Sci Rep"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ejim.2015.11.026","article-title":"Uric acid in metabolic syndrome: From an innocent bystander to a central player","volume":"29","author":"Kanbay","year":"2016","journal-title":"Eur J Internal Med"},{"key":"B17","first-page":"98","article-title":"Hyperuricemia as a potential determinant of metabolic syndrome","volume":"3","author":"Yadav","year":"2013","journal-title":"J Lifestyle Med"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01741-x","article-title":"Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation","volume":"33","author":"Dey","year":"2025","journal-title":"Inflammopharmacol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111932","article-title":"Signaling pathways in uric acid homeostasis and gout: From pathogenesis to therapeutic interventions","volume":"132","author":"Yang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.06.015","article-title":"Advances in our understanding of gout as an auto-inflammatory disease","volume":"50","author":"Bodofsky","year":"2020","journal-title":"Semin Arthritis Rheumatism"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43132","article-title":"Caught red-handed: uric acid is an agent of inflammation","volume":"120","author":"Shi","year":"2010","journal-title":"J Clin Invest"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.988686","article-title":"Relationship between cytokine release and stress hyperglycemia in patients hospitalized with COVID-19 infection","volume":"9","author":"Da Porto","year":"2022","journal-title":"Front Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034509.14906.AE","article-title":"Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans","volume":"106","author":"Esposito","year":"2002","journal-title":"Circulation"},{"key":"B24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jdin.2020.05.005","article-title":"Hidradenitis suppurativa is an autoinflammatory keratinization disease: A review of the clinical, histologic, and molecular evidence","volume":"1","author":"Frew","year":"2020","journal-title":"JAAD Int"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14072145","article-title":"Endotyping insulin\u2013glucose homeostasis in hidradenitis suppurativa: the impact of diabetes mellitus and inflammation","volume":"14","author":"Abu Rached","year":"2025","journal-title":"J Clin Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2660","article-title":"Relative hyperglycemia, a marker of critical illness: introducing the stress hyperglycemia ratio","volume":"100","author":"Roberts","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B27","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.physbeh.2011.06.004","article-title":"Allostasis: a model of predictive regulation","volume":"106","author":"Sterling","year":"2012","journal-title":"Physiol Behav"},{"key":"B28","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol Rev"},{"key":"B29","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/cplx.21743","article-title":"Allostatic load as a complex clinical construct: A case-based computational modeling approach","volume":"21","author":"Buckwalter","year":"2016","journal-title":"Complexity"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2019.07.010","article-title":"Allostasis: A brain-centered, predictive mode of physiological regulation","volume":"42","author":"Schulkin","year":"2019","journal-title":"Trends Neurosci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/BF02476936","article-title":"Neuroendocrine control of thyroid secretion in living systems: a feedback control system model","volume":"30","author":"DiStefano","year":"1968","journal-title":"Bull Math Biophys"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0373","article-title":"THYROSIM app for education and research predicts potential health risks of over-the-counter thyroid supplements","volume":"26","author":"Han","year":"2016","journal-title":"Thyroid"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.888429","article-title":"Optimized replacement T4 and T4+T3 dosing in male and female hypothyroid patients with different BMIs using a personalized mechanistic model of thyroid hormone regulation dynamics","volume":"13","author":"Cruz-Loya","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"12358","DOI":"10.1038\/s41598-024-63158-w","article-title":"Impaired autonomic function and somatosensory disturbance in patients with treated autoimmune thyroiditis","volume":"14","author":"Bazika-Gerasch","year":"2024","journal-title":"Sci Rep"},{"key":"B35","doi-asserted-by":"crossref","DOI":"10.7208\/chicago\/9780226823157.001.0001","volume-title":"Rethinking hypothyroidism","author":"Bianco","year":"2022"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1806508\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:22:28Z","timestamp":1772515348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1806508\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":35,"alternative-id":["10.3389\/fendo.2026.1806508"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1806508","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"article-number":"1806508"}}