{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:43:00Z","timestamp":1776058980270,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    Apolipoprotein M (apoM) is a biologically important protein that facilitates the mobilization and transport of cholesterol and other bioactive molecules in circulation. This study aims to explore the association between plasma apolipoprotein M (apoM) levels and diabetic retinopathy in patients with type 2 diabetes mellitus (T2DM). This cross\u2212sectional study included 339 patients with T2DM. Patients with diabetic retinopathy exhibited greater median plasma apoM levels than those without diabetic retinopathy (26.05 [21.09\u201330.37] mg\/L vs. 21.47 [18.00\u201326.38] mg\/L;\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt;\u00a00.001). In logistic regression models, plasma apoM levels were significantly associated with diabetic retinopathy (odds ratio [OR] per standard deviation increase in log\n                    <jats:sub>10<\/jats:sub>\n                    \u2212transformed levels, 1.49; 95% confidence interval [CI], 1.05\u20132.119;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.027) after adjusting for the confounders including age, hypertension, diabetes duration, and HbA\n                    <jats:sub>1c<\/jats:sub>\n                    . The area under the receiver operating characteristic curve was 0.657 (95% CI: 0.594\u20130.721), with internal bootstrap validation yielding a stable optimism-corrected area under the curve of 0.658. Our exploratory findings suggest a significant positive association between plasma apoM levels and diabetic retinopathy in patients with T2DM.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2026.1809680","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:46:59Z","timestamp":1776055619000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between apolipoprotein M levels and diabetic retinopathy in patients with type 2 diabetes mellitus"],"prefix":"10.3389","volume":"17","author":[{"given":"Jin Ook","family":"Chung","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon-Young","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Jin","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S012","article-title":"12. 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