{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:26:51Z","timestamp":1778675211768,"version":"3.51.4"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic peripheral neuropathy (DPN) constitutes the most prevalent chronic complication of diabetes mellitus, affecting approximately 50% of patients throughout their disease course. Accumulating evidence indicates that gut microbiota (GM) dysbiosis plays a pivotal role in DPN pathogenesis via the gut-brain axis. However, a comprehensive bibliometric analysis delineating the intellectual landscape and evolutionary trajectory of this rapidly advancing research domain remains absent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Publications pertaining to gut microbiota and DPN were systematically retrieved from the Web of Science, PubMed, and Scopus databases (spanning 2010\u20132025). CiteSpace 6.4.R1 was employed to perform co-occurrence, clustering, timeline, burst detection, and co-citation analyzes, thereby visualizing the field\u2019s intellectual structure and developmental trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 133 publications met the inclusion criteria, exhibiting exponential growth after 2018 with an average annual increase of 35.7%. Keyword analysis identified core research clusters centered on GM, neuropathic pain, the gut-brain axis, and therapeutic interventions such as fecal microbiota transplantation (FMT), traditional Chinese medicine, and causal inference methodologies like Mendelian randomization. Burst detection analysis revealed a temporal shift from foundational concepts (e.g., \u201coxidative stress\u201d, \u201cinflammation\u201d) toward interventional strategies (e.g., \u201cfecal microbiota transplantation\u201d, \u201ctraditional Chinese medicine\u201d) and causal inference approaches (e.g., \u201cMendelian randomization\u201d). Co-citation analysis highlighted seminal contributions, including clinical trials demonstrating FMT efficacy and animal studies elucidating the role of microbial metabolites such as butyrate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study presents the inaugural bibliometric analysis of the GM-DPN research field. The domain is transitioning from establishing associative links to elucidating causal mechanisms and evaluating targeted interventions. Keyword trend analysis underscores a convergence toward a multi-mechanistic gut-brain axis model. Future research priorities derived from the literature encompass clinical translation, multi-omics integration, and personalized therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1815280","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:06:29Z","timestamp":1778673989000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the gut microbiota-diabetic peripheral neuropathy research landscape: a bibliometric analysis of emerging trends and translational frontiers"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuda","family":"Fei","sequence":"first","affiliation":[{"name":"Department of Infection Control, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]},{"name":"Graduate School, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Mao","sequence":"additional","affiliation":[{"name":"Graduate School, Beijing University of Chinese Medicine","place":["Beijing, China"]},{"name":"Department of Pain Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bifa","family":"Fan","sequence":"additional","affiliation":[{"name":"Graduate School, Beijing University of Chinese Medicine","place":["Beijing, China"]},{"name":"Department of Pain Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41572-019-0097-9","article-title":"Diabetic neuropathy","volume":"5","author":"Feldman","year":"2019","journal-title":"Nat Rev Dis 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