{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:14:17Z","timestamp":1783606457377,"version":"3.55.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Complete disappearance after thermal ablation for benign thyroid nodules is a time-dependent process with substantial inter-individual variability. Whether baseline systemic inflammatory\u2013immune status contributes to the kinetics of post-ablation absorption remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between pre-ablation derived neutrophil-to-lymphocyte ratio (dNLR) and time to complete disappearance (VRR\u00a0=\u00a0100%) after ultrasound-guided thermal ablation of benign thyroid nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This single-center retrospective cohort analyzed time to ultrasound-defined VRR\u00a0=\u00a0100% as a time-to-event endpoint. Associations were assessed using Cox regression (log2-transformed dNLR per doubling), with stratification by ablation modality when needed. Discrimination was evaluated using Harrell\u2019s C-index, and incremental value was assessed by comparing a prespecified clinical\u2013procedural base model with and without dNLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over 60 months, 95\/187 (50.8%) achieved VRR\u00a0=\u00a0100% (median 37 months). dNLR per doubling was associated with earlier VRR\u00a0=\u00a0100% in univariable analysis (HR 2.44, 95% CI 1.63\u20133.65; P &amp;lt; 0.001) and remained independently associated in the modality-stratified multivariable model (HR 2.28, 95% CI 1.51\u20133.43; P &amp;lt; 0.001). The model including dNLR showed moderate discrimination (C-index 0.728, 95% CI 0.675\u20130.782) and adding dNLR modestly improved discrimination (\u0394C-index \u2248 0.02; likelihood ratio test P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher pre-ablation dNLR was independently associated with earlier complete disappearance after thermal ablation and may provide complementary information for counseling and follow-up planning; however, its incremental discrimination was modest and external validation is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1817575","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:18:35Z","timestamp":1777609115000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre-ablation derived neutrophil-to-lymphocyte ratio is associated with time to complete disappearance after thermal ablation of benign thyroid nodules: a retrospective cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Pei-Cheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Thyroid Surgery, Weihai Central Hospital","place":["Weihai, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, Wendeng District People\u2019s Hospital","place":["Weihai, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jia","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jie","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, Weihai Central Hospital","place":["Weihai, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-An","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2021.1988151","article-title":"A study on the efficacy of microwave ablation for benign thyroid 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