{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:46:03Z","timestamp":1793727963617,"version":"4.6.1"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803318"],"award-info":[{"award-number":["81803318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["232300420069, 232102310231, 232300420289"],"award-info":[{"award-number":["232300420069, 232102310231, 232300420289"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018925","name":"Health Commission of Henan Province","doi-asserted-by":"publisher","award":["LHGJ20230940, LHGJ20230942"],"award-info":[{"award-number":["LHGJ20230940, LHGJ20230942"]}],"id":[{"id":"10.13039\/100018925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>TyHGB is a composite metabolic index integrating triglyceride-to-high-density lipoprotein cholesterol ratio, fasting plasma glucose, and body mass index, but its association with World Health Organization (WHO)-defined cardiovascular disease (CVD) high-risk status in community settings remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 6,755 adults from a community-based ChinaHEART Luohe screening cohort (2021\u20132022). CVD high-risk was defined as an estimated 10-year WHO CVD risk \u226520%. TyHGB was examined per 1-unit increase and as high versus low using a receiver operating characteristic (ROC)-derived cutoff (Youden index; approximately 7.6). Logistic regression and restricted cubic splines were used to assess associations and potential nonlinearity. Discrimination was evaluated using ROC curves with DeLong\u2019s tests, and incremental value beyond conventional risk factors was assessed using integrated discrimination improvement (IDI) and net reclassification improvement (NRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of CVD high-risk was 22%. TyHGB was independently associated with CVD high-risk (fully adjusted OR 1.131 per 1-unit increase), and high TyHGB (\u22657.6) was associated with higher odds (OR 1.642). In unadjusted analyses, TyHGB showed higher discrimination than TyG (AUC 0.624 vs 0.585). Adding TyHGB to the base model modestly improved reclassification (IDI 0.003; NRI 0.216). TyHGB was also retained in exploratory machine-learning analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>TyHGB was positively associated with WHO-defined CVD high-risk and provided modest incremental discrimination and reclassification for cross-sectional high-risk classification beyond conventional risk factors, supported by sensitivity analyses. These findings relate to estimated risk status rather than adjudicated incident CVD events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1818472","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:56:38Z","timestamp":1778129798000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["TyHGB and CVD high-risk stratification: nonlinear association and discrimination in the ChinaHEART Luohe study"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhiwei","family":"Huang","sequence":"first","affiliation":[{"name":"Luohe Central Hospital, Luohe Medical College","place":["Luohe, China"]},{"name":"Henan University College of Medicine, Henan University","place":["Kaifeng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirui","family":"Cai","sequence":"additional","affiliation":[{"name":"Luohe Central Hospital, Luohe Medical College","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bai","sequence":"additional","affiliation":[{"name":"Luohe Central Hospital, Luohe Medical College","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Luohe Central Hospital, Luohe Medical College","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabo","family":"Huang","sequence":"additional","affiliation":[{"name":"Luohe Central Hospital, Luohe Medical College","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Guo","sequence":"additional","affiliation":[{"name":"Luohe Central Hospital, Luohe Medical College","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Luohe Central Hospital, Luohe Medical College","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guirang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Luohe Center for Disease Control and Prevention","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaotao","family":"Xie","sequence":"additional","affiliation":[{"name":"Luohe Central Hospital, Luohe Medical College","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[{"name":"Luohe Central Hospital, Luohe Medical College","place":["Luohe, China"]},{"name":"Henan Key Laboratory of Fertility Protection and Aristogenesis","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: Update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30318-3","article-title":"World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions","volume":"7","year":"2019","journal-title":"Lancet Glob Health"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000678","article-title":"2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: A report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines","volume":"140","author":"Arnett","year":"2019","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1089\/met.2008.0034","article-title":"The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects","volume":"6","author":"Simental-Mend\u00eda","year":"2008","journal-title":"Metab Syndr Relat Disord"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin sensitivity. 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