{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:29:12Z","timestamp":1790738952677,"version":"4.1.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D has been implicated in ovarian physiology, yet its effect on ovarian reserve remains controversial. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the influence of vitamin D supplementation on ovarian reserve as indicated by serum anti-M\u00fcllerian hormone (AMH) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Cochrane Library, Embase, Web of Science, Wanfang, and CNKI were searched for RCTs comparing vitamin D supplementation with placebo or no intervention on AMH in women of reproductive age. The pooled effect was summarized as standardized mean difference (SMD) using a random-effects model by incorporating the influence of potential heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven RCTs with 992 women were included. Overall, vitamin D supplementation did not significantly affect serum AMH levels (SMD: \u22120.20; 95% CI: \u22120.48 to 0.08; p = 0.16), with substantial heterogeneity (I\u00b2 = 77%, p &amp;lt; 0.001). Subgroup analysis showed no significant effect in double-blind trials but a reduction in AMH in open-label trials (p for subgroup difference = 0.02). A significant interaction was observed according to baseline AMH level (p = 0.003), with a reduction in studies where baseline AMH &amp;gt; 6 ng\/mL (SMD: \u22120.55; 95% CI: \u22120.87 to \u22120.23). No significant subgroup differences were found by age, baseline 25(OH)D, vitamin D dose, treatment duration, or assay method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current randomized evidence suggests that vitamin D supplementation was not likely to alter AMH levels in reproductive-aged women overall. The certainty of evidence was moderate, and findings should be interpreted cautiously given substantial heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>\n                      , identifier CRD420261329210.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1832704","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:23:48Z","timestamp":1778473428000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of vitamin D supplementation on ovarian reserve as reflected by anti-M\u00fcllerian hormone levels: a meta-analysis of randomized controlled 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