{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:59:53Z","timestamp":1781240393757,"version":"3.54.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The diagnostic workup of polyuria-polydipsia syndrome (PPS) is not well-established in children and adolescents, and several non-osmotic copeptin-stimulating agents have been investigated. Glucagon stimulation test (GST) induced a robust copeptin response in adults, but data in children are lacking. This study aimed to investigate copeptin response to GST in children tested for suspected growth hormone (GH) deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty children (9 girls, age 10.3 \u00b1 2.9 years) with no PPS underwent GST (30 \u00b5g\/kg of glucagon i.m.). Plasma glucose, GH, cortisol, and copeptin were measured before and 60, 90, 120, 150, and 180\u00a0min after glucagon injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median copeptin concentration was 4.1 pmol\/L (IQR 3.3\u20136.7) at baseline and 10.6 pmol\/L (5.4-17.9) at peak concentration (+87% at 150\u00a0min). No adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GST is safe and effective at enhancing copeptin secretion in children with intact neurohypophysial function, and further studies are warranted to assess its accuracy in the differential diagnosis of PPS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1833629","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:45:15Z","timestamp":1781239515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Glucagon-stimulated copeptin response in children: a proof-of-concept study"],"prefix":"10.3389","volume":"17","author":[{"given":"Rita","family":"Indirli","sequence":"first","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore 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Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Rodari","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico di Milano","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia","family":"Petria","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico di Milano","place":["Milan, Italy"]},{"name":"Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Arosio","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico di Milano","place":["Milan, Italy"]},{"name":"Department of Clinical Sciences and Community Health, 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