{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:51:23Z","timestamp":1781675483553,"version":"3.54.5"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insulin resistance has been linked to adverse reproductive and pregnancy outcomes. The triglyceride glucose\u2013body mass index (TyG-BMI) serves as a simple and cost-effective surrogate marker of insulin resistance. This study aimed to investigate the association between maternal TyG-BMI and cumulative live birth as well as pregnancy outcomes in women undergoing assisted reproductive technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 53,393 women undergoing assisted reproductive technology at the Reproductive and Genetic Hospital of CITIC-Xiangya, China, between January 1, 2017, and March 31, 2023. Associations between baseline TyG-BMI and assisted pregnancy outcomes were estimated using modified Poisson regression and restricted cubic splines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant linear inverse association was observed between TyG-BMI and cumulative live birth rate (\n                      <jats:italic>P<\/jats:italic>\n                      -overall = 0.029). Compared with women in the lowest TyG-BMI tertile (\u2264177), those in the highest tertile (&amp;gt;203) had a lower cumulative live birth rate (aRR 0.973; 95% confidence interval 0.956\u20130.991). Higher TyG-BMI was also associated with higher risks of first-trimester miscarriage (aRR, 1.090; 95% confidence interval 1.002-1.185), second- or third-trimester fetal loss (aRR 1.694; 95% confidence interval 1.481\u20131.938), preterm birth (aRR 1.244; 95% confidence interval 1.170\u20131.323), and macrosomia (aRR 2.352; 95% confidence interval 2.060\u20132.685).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher maternal TyG-BMI is associated with reduced cumulative live birth rates and higher risks of adverse pregnancy outcomes including miscarriage, preterm birth, and macrosomia following assisted reproductive technology. TyG-BMI may be a potential and cost-effective marker associated with adverse reproductive outcomes in women undergoing fertility treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      , identifier NCT05404464.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1842023","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:51:46Z","timestamp":1781671906000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated triglyceride glucose-body mass index is associated with a higher risk of reduced cumulative live birth and adverse pregnancy outcomes in women undergoing assisted reproductive technology: a retrospective cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Jie","family":"Hu","sequence":"first","affiliation":[{"name":"Xiangya School of Public Health, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya","place":["Changsha, Hunan, China"]},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Sciences, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyan","family":"Gao","sequence":"additional","affiliation":[{"name":"Xiangya School of Public Health, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqin","family":"Peng","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya","place":["Changsha, Hunan, China"]},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Sciences, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya","place":["Changsha, Hunan, China"]},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Sciences, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene X. Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Xiangya School of Public Health, Central South University","place":["Changsha, Hunan, China"]},{"name":"Central South University, Hunan Provincial Key Laboratory of Clinical Epidemiology","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gong","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya","place":["Changsha, Hunan, China"]},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Sciences, Central South University","place":["Changsha, Hunan, 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