{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:45:14Z","timestamp":1793897114247,"version":"4.8.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Short-form video platforms such as TikTok and YouTube Shorts are major sources of health information, yet little is known about the reliability of what they carry on incretin-based therapies for obesity. We assessed the accuracy, safety, obesity-related stigma, and commercial nature of short-form videos on these medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional content analysis on June 15, 2025. Videos were retrieved for six medication keywords on TikTok and YouTube Shorts, and the 100 most-viewed videos within each platform\u2019s retrieved pool were included (n = 200). Four physicians certified by the American Board of Obesity Medicine each coded a non-overlapping subset for clinical accuracy, hazard potential, obesity stigma, and commercial influence. A fifth senior physician reviewed all videos and issued final ratings. Six TikTok videos became unavailable before review, leaving 194 for content analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TikTok videos had higher median view counts (964 650 [Q1\u2013Q3 615 350\u20131 525 000] vs 24 526 [7 036\u2013104 569],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001) and higher raw like and comment counts. Normalizing to views changed the picture. Likes per 1000 views did not differ (24.7 vs 20.4, p = 0.069), and comments per 1000 views were higher on YouTube Shorts (1.2 vs 0.8, p &amp;lt; 0.001), where videos were also older (720 vs 221 days, p &amp;lt; 0.001). Clinical accuracy did not differ significantly (23.4% [95% CI 16.0\u201332.9%] vs 39.0% [95% CI 30.0\u201348.8%], p = 0.062). Hazard potential was more common on TikTok (31.9% vs 17.0%, p = 0.015), but this came from promotion of compounded products, four times more frequent on TikTok (14.9% vs 4.0%, p = 0.009). Restricted to directly unsafe clinical content, the platforms did not differ (20.2% vs 13.0%, p = 0.176). Obesity stigma (p = 0.118) and commercial influence (p = 0.438) were comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most short-form videos about incretin-based obesity therapies carried no accurate clinical information, and accurate videos drew only 24% of cumulative views. Promotion of compounded products clustered on TikTok and accounted for the platform difference in hazard potential. Evidence-based, bias-free communication is needed if these platforms are to educate the public about obesity pharmacotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1844311","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:40:22Z","timestamp":1790916022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Accuracy, potential harm, weight stigma, and commercial influence in short-form social media content on incretin-based therapies for obesity"],"prefix":"10.3389","volume":"17","author":[{"given":"Yeo-Jun","family":"Yoon","sequence":"first","affiliation":[{"name":"Harvard T.H. Chan School of Public Health","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Velazquez","sequence":"additional","affiliation":[{"name":"Jim and Eleanor Randall Department of Surgery, Cedars Sinai Medical Center","place":["Los Angeles, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehej-Leen","family":"Parmar","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katayoun","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Palo Alto Medical Foundation","place":["Palo Alto, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Wong","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, Boston Medical 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Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangmo","family":"Hong","sequence":"additional","affiliation":[{"name":"Hanyang University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungoo","family":"Shin","sequence":"additional","affiliation":[{"name":"Hanyang University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Apovian","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, MA, United States"]},{"name":"Center for Weight Management and Wellness, Division of Endocrinology, Diabetes & Hypertension, Brigham and Women\u2019s Hospital","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, 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