{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:08:20Z","timestamp":1780549700241,"version":"3.54.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to explore the correlation between atherogenic index of plasma (AIP) and the risk of aortic valve calcification (AVC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This single-center retrospective cohort study included 1,752 participants from the First Affiliated Hospital of Xinjiang Medical University, from May 27, 2023, to Ju\\ly 27, 2025. Participants were divided into two groups based on AVC at follow-up: non\u2013AVC group (n = 1,463) and AVC group (n = 289). Multivariate logistic regression, subgroup and sensitivity analyses, and receiver operating characteristic (ROC) curve analysis evaluated the evaluate the correlation between AIP and AVC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariable logistic regression analysis showed that each 1-unit increase in AIP was associated with a 146.0% higher risk of AVC (OR\u00a0=\u00a02.460, 95% CI 1.525\u20133.969). When participants were grouped by AIP quartiles, compared with the lowest quartile (Q1), the risk of AVC in the Q2, Q3, and Q4 groups was 1.623-fold (95% CI 1.080\u20132.439, P\u00a0=\u00a00.020), 2.405-fold (95% CI 1.622\u20133.567, P &amp;lt; 0.001), and 2.319-fold (95% CI 1.564\u20133.439, P &amp;lt; 0.001), respectively. Subgroup analysis indicated that higher AIP levels remained significantly associated with an increased risk of AVC across most subgroups (all P &amp;lt; 0.05). Sensitivity analysis, after excluding participants with eGFR &amp;lt; 60 mL\/min\/1.73 m\u00b2, showed that each 1-unit increase in AIP was associated with a 143.2% higher risk of AVC. In that analysis, the AVC risk in Q2, Q3, and Q4 remained 2.086-fold, 2.928-fold, and 3.172-fold that of Q1, respectively. When grouped by the median AIP, the high-AIP group had a 1.996-fold higher risk; when grouped by the mean AIP, the risk was 2.067-fold higher. Using AIP tertiles, the Q2 and Q3 groups had 2.151-fold and 2.807-fold higher risks, respectively. ROC curve analysis indicated that AIP had moderate diagnostic value for AVC risk (AUC\u00a0=\u00a00.760, 95% CI 0.732\u20130.789). In contrast, the AUCs for triglycerides (0.594) and total cholesterol (0.538) were significantly lower than that of AIP (DeLong test, both P &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher levels of AIP are significantly associated with an increased risk of AVC, indicating that AIP holds important clinical value as an associative biomarker for AVC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1846100","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:44:39Z","timestamp":1780548279000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The correlation between the atherogenic index of plasma and aortic valve calcification in the general population: a retrospective observational cohort 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