{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:56:23Z","timestamp":1781585783981,"version":"3.54.5"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Obstructive sleep apnea-hypopnea syndrome (OSAHS) is closely associated with coronary heart disease (CHD) and adverse cardiovascular outcomes, but the comparative value of the triglyceride-glucose (TyG) index and its body fat distribution composites for cardiovascular risk stratification in OSAHS remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed the associations of TyG, TyG-weight-adjusted waist index (TyG-WWI), TyG-Chinese visceral adiposity index (TyG-CVAI), and TyG-body roundness index (TyG-BRI) with prevalent CHD and incident major adverse cardiovascular events (MACE) in adults with OSAHS. This single-center retrospective observational study included 1,122 adults with OSAHS who underwent both polysomnography and coronary angiography, including 533 patients with CHD and 589 without CHD. TyG-related indices were standardized and analyzed per 1-standard deviation increase. Multivariable logistic regression, restricted cubic spline analysis, Cox proportional hazards models, time-dependent receiver operating characteristic analysis, and exploratory statistical decomposition were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All TyG-related indices were independently associated with prevalent CHD after full adjustment. TyG-WWI showed the strongest association (odds ratio 3.21, 95% confidence interval 2.68-3.89 per 1-standard deviation increase). Adding TyG-WWI to conventional risk factors plus apnea-hypopnea index provided the greatest improvement in CHD discrimination (area under the curve 0.802; integrated discrimination improvement 0.150; continuous net reclassification improvement 0.706; all P&amp;lt;0.001). During a median follow-up of 17 months, 80 MACE occurred, and TyG-WWI showed the strongest association with incident MACE among the evaluated indices(hazard ratio 1.545, 95% confidence interval 1.217-1.961). Exploratory statistical decomposition suggested potential indirect pathway signals involving TyG-WWI and TyG-CVAI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In this selected high-risk cohort of adults with OSAHS undergoing coronary evaluation, TyG and its adiposity-based composites were associated with prevalent CHD and showed supportive associations with follow-up MACE. TyG-WWI showed the most consistent cross-sectional, supportive longitudinal, and incremental discriminative value, suggesting its potential as a candidate marker for cardiovascular risk stratification. Given the limited MACE events and the exploratory nature of the statistical decomposition, these findings should be interpreted cautiously and validated prospectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1848218","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:26:40Z","timestamp":1781584000000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the TyG index and its body fat distribution composites with CHD and MACE risk in adults with OSAHS: incremental discrimination and exploratory mediation analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Zeyu","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Hypertension, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, 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Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulixian","family":"Shata","sequence":"additional","affiliation":[{"name":"Department of Hypertension, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehanguli","family":"Maihemutijiang","sequence":"additional","affiliation":[{"name":"Department of Hypertension, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41392-023-01496-3","article-title":"Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome","volume":"8","author":"Lv","year":"2023","journal-title":"Signal Transduct Target 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