{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:04:58Z","timestamp":1780031098202,"version":"3.53.1"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to examine the relationship between the neutrophil to high-density lipoprotein cholesterol ratio (NHR) and the uric acid to high-density lipoprotein cholesterol ratio (UHR) in early pregnancy and the development of GDM, and to analyze the predictive value of these factors in combination, with a view to providing a basis for the early clinical prevention and treatment of GDM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study population comprised primiparous women carrying a single fetus who received routine antenatal care and examinations at the Obstetrics Department of Yuncheng Central Hospital between January 2024 and December 2025. General clinical data were collected, along with results for blood tests, fasting glucose levels, and lipid profiles from weeks 10~13 of pregnancy. The results of the glucose tolerance test conducted between 24 and 28 weeks of gestation were used to divide the study participants into two groups: a GDM group and a non-GDM group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the non-GDM group, patients in the GDM group exhibited significantly elevated levels of the inflammatory markers NHR and UHR (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). Glucose levels at 0\u00a0h, 1\u00a0h, and 2\u00a0h during the OGTT showed a gradual upward trend as NHR and UHR quartile groups increased (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). Spearman\u2019s rank correlation analysis revealed that serum NHR and UHR levels in women at 10~13 weeks\u2019 gestation were positively correlated with GDM (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). Multivariate logistic regression analysis indicated that both NHR and UHR were independent risk factors for the development of GDM (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). ROC analysis demonstrated that NHR and UHR could serve as potential predictive markers for assessing the occurrence of GDM after 24 weeks of gestation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated levels of NHR and UHR in early pregnancy are positively correlated with the development of GDM. They constitute independent risk factors for its onset and possess a certain degree of predictive value, thereby providing a reference for the early clinical prevention and management of GDM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1848926","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:47:53Z","timestamp":1780030073000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the predictive value of NHR and UHR levels in early pregnancy for gestational diabetes mellitus: based on a retrospective analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Ting","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory Department of Yuncheng Central Hospital","place":["Yuncheng, Shanxi, 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