{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:08:53Z","timestamp":1780463333726,"version":"3.54.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017959","name":"Health Commission of Hebei Province","doi-asserted-by":"publisher","award":["20251555"],"award-info":[{"award-number":["20251555"]}],"id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and islet function in postmenopausal women with type 2 diabetes mellitus (T2DM) and osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 343 consecutively hospitalized postmenopausal women with type 2 diabetes mellitus and osteoporosis between December 2024 and December 2025 were included in the final analysis. Participants were classified into three groups according to serum 25(OH)D levels: sufficiency (&amp;gt;30 ng\/mL), insufficiency (20\u201330 ng\/mL), and deficiency (&amp;lt;20 ng\/mL). Clinical characteristics, bone mineral density, and islet function-related indices were compared among the groups. Spearman correlation analysis and multivariable linear regression were performed to evaluate the associations between serum 25(OH)D levels and islet function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences were found among the three groups in age, duration of T2DM, or glycated hemoglobin (HbA1c) (all P &amp;gt; 0.05), whereas body mass index (BMI) showed a marginal overall difference among the groups (P\u00a0=\u00a00.047). Lumbar spine, femoral neck, and total hip T-scores were progressively lower across groups with lower serum 25(OH)D levels (all P &amp;lt; 0.001). Fasting insulin (FINS), fasting C-peptide (FCP), homeostasis model assessment of \u03b2-cell function (HOMA-\u03b2), and homeostasis model assessment of insulin resistance (HOMA-IR) also showed significant intergroup differences (all P &amp;lt; 0.001). Serum 25(OH)D was positively correlated with fasting insulin, fasting C-peptide, and HOMA-\u03b2, but negatively correlated with HOMA-IR (all P &amp;lt; 0.001). Multivariable analysis showed that serum 25(OH)D remained associated with islet function and insulin resistance after adjustment for age, BMI, HbA1c, and T2DM duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In postmenopausal women with type 2 diabetes mellitus and osteoporosis, lower serum 25(OH)D levels were associated with poorer \u03b2-cell function, greater insulin resistance, and lower bone mineral density.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1850506","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:53:12Z","timestamp":1780462392000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum 25-hydroxyvitamin D is associated with islet function in postmenopausal women with type 2 diabetes and osteoporosis"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiuping","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes (Second Division), Cangzhou Central Hospital","place":["Cangzhou,Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis (First Division), Cangzhou Third Hospital","place":["Cangzhou,Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes (Second Division), Cangzhou Central Hospital","place":["Cangzhou,Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cangzhou Heping Hospital","place":["Cangzhou,Hebei, 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