{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:32:16Z","timestamp":1793698336353,"version":"4.5.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There exists a close and complex bidirectional relationship between cardiovascular disease (CVD) and chronic kidney disease (CKD). CVD is a well-established risk factor for CKD, while the Triglyceride glucose-body mass index (TyG-BMI) has been considered as a predictor of cardiovascular events. This was a retrospective case-control study. This study aimed to investigate the relationship between preoperative TyG-BMI and estimated glomerular filtration rate(eGFR) during follow-up in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was performed in 1020 patients with CHD after PCI without CKD from 01\/01\/2015 to 01\/01\/2025. We performed multifaceted analyses of the association between preoperative TyG-BMI and eGFR, including multiple linear regression for continuous eGFR outcomes, logistic regression to identify whether TyG-BMI independently influenced categorical eGFR status and quantify the magnitude of this association, and restricted cubic spline (RCS) analysis to explore non-linear relationships. Low eGFR (&amp;lt;60 mL\/(min*1.73m\u00b2)) was set as the outcome variable, and was obtained from the latest follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The multivariate linear regression analysis revealed no statistically significant linear association between preoperative TyG-BMI and eGFR (\n                      <jats:italic>t<\/jats:italic>\n                      \u00a0=\u00a0-1.850,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.065). Logistic regression indicated that TyG-BMI was not identified as an independent influencing factor of eGFR (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.369,\n                      <jats:italic>OR<\/jats:italic>\n                      \u00a0=\u00a01.003,\n                      <jats:italic>95%CI:<\/jats:italic>\n                      0.977~1.009). RCS analysis indicated that the nonlinear association between TyG-BMI and eGFR was not statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      for nonlinear &amp;gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative TyG-BMI exerted no direct independent effect on long-term outcome of eGFR. It is unlikely that TyG-BMI serves as a primary determinant of CKD in patients with CHD after PCI. Future studies should evaluate combined risk models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1852416","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T04:21:39Z","timestamp":1786076499000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lack of association between Triglyceride glucose-body mass index and glomerular filtration rate in patients with coronary heart disease after percutaneous coronary intervention: a retrospective case-control study"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiaoxu","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Rehabilitation Nursing, Hangzhou Polytechnic University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihe","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Second Clinical Medical College, Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Hangzhou First People\u2019s Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of The First Affiliated Hospital, Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Rehabilitation Nursing, Hangzhou Polytechnic University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Le","sequence":"additional","affiliation":[{"name":"College of Rehabilitation Nursing, Hangzhou Polytechnic University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Rehabilitation Nursing, Hangzhou Polytechnic University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Rehabilitation Nursing, Hangzhou Polytechnic University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease, Yipeng Community Health Service Center","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Hangzhou Cancer Hospital","place":["Hangzhou, 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