{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:00:04Z","timestamp":1781067604264,"version":"3.54.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reduced kidney function often develops in parallel with metabolic dysregulation and chronic low-grade inflammation, yet practical markers that capture both processes remain limited in routine screening settings. We evaluated whether the high-sensitivity C-reactive protein\u2013triglyceride-glucose composite index (CTI), an integrated marker derived from hs-CRP and the triglyceride-glucose index, was associated with reduced estimated glomerular filtration rate (eGFR) in adults undergoing health examinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 1429 adults with complete core variables from an independent hospital-based cohort established at the Health Examination Center of the Second Affiliated Hospital of Shandong First Medical University between June 2024 and December 2025. CTI was calculated as TyG + 0.412 \u00d7 ln [hs-CRP (mg\/L)], where TyG = ln [TG (mg\/dL) \u00d7 fasting plasma glucose (mg\/dL)\/2]. The primary outcome was single-occasion reduced eGFR, defined as &amp;lt;90 mL\/min\/1.73 m\u00b2, and was not interpreted as chronic kidney disease. Multivariable logistic regression, restricted cubic spline analysis, receiver operating characteristic analysis, subgroup analysis, variance inflation factor diagnostics, and sensitivity analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean (SD) age was 48.8 (11.3) years, 46.8% of participants were women, and 398 individuals (27.9%) had single-occasion reduced eGFR. The prevalence of reduced eGFR increased across CTI quartiles, from 12.8% in the lowest quartile to 45.7% in the highest quartile. After adjustment for demographic factors, lifestyle factors, cardiometabolic comorbidities, and uric acid, each 1-SD increment in CTI was associated with 45% higher odds of reduced eGFR (odds ratio [OR], 1.45; 95% CI, 1.11-1.90). Compared with the lowest quartile, the highest quartile showed an OR of 2.11 (95% CI, 1.07-4.17), whereas the adjusted linear trend across quartiles was borderline (P for trend = .056). Only 1 participant (0.1%) had eGFR &amp;lt;60 mL\/min\/1.73 m\u00b2; using a stricter eGFR &amp;lt;75 mL\/min\/1.73 m\u00b2 threshold yielded a directionally similar but borderline association (OR, 1.75; 95% CI, 0.99-3.10). CTI discriminated reduced eGFR modestly but better than TyG, hs-CRP, and remnant cholesterol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this health examination population, higher CTI was independently associated with a higher prevalence of single-occasion reduced eGFR. Because discrimination was modest and the design was cross-sectional, CTI should be interpreted as an adjunctive marker of metabolic-inflammatory burden rather than a diagnostic or predictive tool. Prospective validation is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1859383","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:27:12Z","timestamp":1781065632000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["High-sensitivity C-reactive protein\u2013triglyceride-glucose composite index and reduced estimated glomerular filtration rate in adults undergoing routine health examinations: a cross-sectional study"],"prefix":"10.3389","volume":"17","author":[{"given":"Hao","family":"Sun","sequence":"first","affiliation":[{"name":"Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Yu","sequence":"additional","affiliation":[{"name":"Qingdao Municipal Hospital, University of Health and Rehabilitation 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