{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:52:56Z","timestamp":1781844776300,"version":"3.54.5"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypoglycemia is a common complication that is closely associated with poor prognosis in older patients with diabetes undergoing hemodialysis (HD). However, evidence regarding simple intradialytic preventive strategies remains limited. We evaluated the short-term effects of 15\u00a0g oral glucose solution on blood glucose levels and blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-arm, self-controlled, pre-post pilot study included 12 older patients with diabetes undergoing HD between September and October 2025. Participants were selected from a previously monitored cohort according to documented hypoglycemia during HD-day continuous glucose monitoring (CGM). Patients who experienced hypoglycemia on HD received a 15\u00a0g oral glucose solution 1.5\u00a0h after starting HD. Blood glucose levels were then monitored via CGM. Paired pre-post comparisons were performed at the patient level. Blood glucose and pressure fluctuations were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the pre-intervention period, the incidence of hypoglycemia, time below range, and coefficient of variation were significantly lower during the entire HD day, during the HD session, and within 2\u00a0h post-HD (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05). Mean blood glucose levels were significantly higher after the intervention (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05). The incidence of hypotension and systolic\/diastolic blood pressure did not differ significantly at any time point during HD (0\u20134) or before and after the intervention (all\n                      <jats:italic>P<\/jats:italic>\n                      &amp;gt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oral supplementation with 15\u00a0g of glucose solution administered 1.5\u00a0h into HD was associated with a short-term reduction in hypoglycemia in older patients with diabetes undergoing HD using glucose-free dialysate, without an observed increase in hypotension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:related-object>\n                      <jats:ext-link>http:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      , identifier: ChiCTR2500100945\n                    <\/jats:related-object>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1861404","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:28:50Z","timestamp":1781843330000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Short-term effect of oral glucose solution in older patients with hypoglycemia undergoing hemodialysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Jinzhu","family":"Li","sequence":"first","affiliation":[{"name":"Department of the Sixth Health Care, The Second Medical Centre & National Clinical Research Centre, Chinese People\u2019s Liberation Army (PLA) General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Geriatric Nephrology, The Second Medical Centre & National Clinical Research Centre, Chinese People\u2019s Liberation Army (PLA) General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Nephrology, The Second Medical Centre & National Clinical Research Centre, Chinese People\u2019s Liberation Army (PLA) General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Medical Center & National Clinical Research Center, Chinese People\u2019s Liberation Army (PLA) General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of the Sixth Health Care, The Sixth Medical Centre, Chinese People\u2019s Liberation Army (PLA) General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanda","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Medical Centre, Chinese People\u2019s Liberation Army (PLA) General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Nephrology, The Second Medical Centre & National Clinical Research Centre, Chinese People\u2019s Liberation Army (PLA) General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"B1","unstructured":"2025 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States\n          \n          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