{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T04:26:11Z","timestamp":1787199971216,"version":"build-2736575974"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["GJIH-1599-04-1-180; MH CZ-DRO General University Hospital 00064165; MH CZ-DRO Motol University Hospital 00064203 and the project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, Project No. LX22NPO5104) - Funded by the European Union - Next Generation EU.)"],"award-info":[{"award-number":["GJIH-1599-04-1-180; MH CZ-DRO General University Hospital 00064165; MH CZ-DRO Motol University Hospital 00064203 and the project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, Project No. LX22NPO5104) - Funded by the European Union - Next Generation EU.)"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Preoperative localization is essential for the surgical management of primary hyperparathyroidism (PHPT). Ultrasound and 99mTc-sestamibi SPECT\/CT are first-line imaging modalities, while MRI\u2019s role is less defined. This study aimed to evaluate MRI for parathyroid adenoma localization in PHPT and compare it with that of ultrasound and SPECT\/CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective single-center study, 103 adults with biochemically confirmed PHPT underwent ultrasound, multiparametric 3T MRI, and SPECT\/CT before surgery. MRI examinations were independently evaluated independently evaluated by two blinded radiologists. Surgical and histopathological findings served as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-three patients (90%) had single-gland disease (SGD), and 10 (10%) multiglandular disease (MGD). MRI demonstrated high sensitivity for adenomas in SGD but significantly lower sensitivity in MGD: Reader 1, 0.824 vs 0.476 (p = 0.002) and Reader 2, 0.890 vs 0.524 (p &amp;lt; 0.001). Ultrasound and SPECT\/CT showed similar patterns. Specificity did not differ significantly between SGD and MGD. Inter-reader agreement was high for MRI and ultrasound (Krippendorff\u2019s \u03b1 &amp;gt; 0.8) but decreased when including SPECT\/CT. MRI-based size lesion size measurements showed good concordance between readers (\u03c1C = 0.822) but showed low concordance with histology (\u03c1C1\u00a0=\u00a00.498; \u03c1C2\u00a0=\u00a00.373) due to systematic underestimation (15\u201318%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multiparametric 3T MRI provides localization sensitivity to that of first-line imaging modalities in SGD, but differentiation between MGD and SGD remains challenging, with MRI showing no clear superiority over standard modalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1862421","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T04:16:19Z","timestamp":1787199379000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic performance of 3T MRI preoperative localization of parathyroid adenomas in primary hyperparathyroidism"],"prefix":"10.3389","volume":"17","author":[{"given":"Luk\u00e1\u0161","family":"Lambert","sequence":"first","affiliation":[{"name":"Department of Radiology, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]},{"name":"Department of Imaging Methods, Motol University Hospital and 2 Faculty of Medicine, Charles University","place":["Prague, Czechia"]},{"name":"Faculty of Health Studies, Technical University Liberec","place":["Liberec, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Ivan","family":"Ra\u0161ka","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"V\u00e1clav","family":"H\u00e1na","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Wagnerov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Radiology, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]},{"name":"Institute of Nuclear Medicine, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Boc\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Radiology, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hrdli\u010dka","sequence":"additional","affiliation":[{"name":"Department of Radiology, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judita","family":"Kl\u00edmov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medicine, 1 Faculty of Medicine, Charles University and Military University Hospital in Prague","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Libansk\u00fd","sequence":"additional","affiliation":[{"name":"Third Department of Surgery, Motol University Hospital, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Michalsk\u00e1","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"Zaj\u00ed\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]},{"name":"Institute of Endocrinology","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161 Anton\u00edn","family":"Kub\u011bna","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Burgetov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Radiology, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edt","family":"Zik\u00e1n","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, General University Hospital and 1 Faculty of Medicine, Charles University","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jocd.2012.11.009","article-title":"Epidemiology of primary hyperparathyroidism","volume":"16","author":"Clarke","year":"2013","journal-title":"J Clin Densitom"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-1044","article-title":"European expert consensus on practical management of specific aspects of parathyroid disorders in adults and in pregnancy: Recommendations of the ESE educational program of parathyroid 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