{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:16:21Z","timestamp":1788498981738,"version":"build-2803163510"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteosarcopenia, defined as the coexistence of low bone mass and sarcopenia, is a disabling musculoskeletal condition, yet its gut microbial and metabolic characteristics in clinical populations remain incompletely understood. Integrative multi-omics approaches may help clarify species\u2013metabolite networks associated with this condition, particularly in fracture patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center, prospective cross-sectional study, 69 fracture patients aged \u226550 years were classified into four phenotypes: Normal (n = 18), isolated low bone mass (Bone, n = 18), isolated sarcopenia (Muscle, n = 19), and osteosarcopenia (Both, n = 14). Fecal samples were analyzed using shotgun metagenomics and untargeted metabolomics, yielding paired multi-omics data for 52 participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Bone group had the highest mean age (66.6 \u00b1 9.46 years), whereas the mean ages of the other groups ranged from 60.6 to 61.8 years (overall\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.029), while sex, BMI, lifestyle factors, and comorbidities did not differ significantly. Neither \u03b1-diversity nor overall \u03b2-diversity showed marked differences across phenotypes, suggesting that broad community replacement was not observed. A multi-stage, multi-method strategy yielded a 17-species consensus feature set associated with differences among musculoskeletal phenotypes. Taxonomic patterns were consistent with a candidate fiber\/short-chain fatty acid (SCFA)-associated module, whereas exploratory microbe\u2013metabolite correlations suggested a candidate lipid\/sterol-associated module. The latter included correlations linking\n                      <jats:italic>Firmicutes bacterium<\/jats:italic>\n                      CAG:24053_14 with putatively annotated cholesterol and N-acylethanolamines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Osteosarcopenia in fracture patients was associated with unadjusted differences in selected gut microbial taxa and fecal metabolites within a broadly shared microbial community. These findings are hypothesis-generating and require validation in larger independent cohorts before clinical or biomarker application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1863988","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:27:03Z","timestamp":1788496023000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiome\u2013metabolome signatures of osteosarcopenia in fracture patients in China"],"prefix":"10.3389","volume":"17","author":[{"given":"Minjuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"Beijing Research Institute of Traumatology and Orthopaedics","place":["Beijing, China"]},{"name":"Laboratory for Clinical Medicine, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xieyuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"Beijing Research Institute of Traumatology and Orthopaedics","place":["Beijing, China"]},{"name":"Laboratory for Clinical Medicine, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised european consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00198-018-4704-5","article-title":"European guidance for the diagnosis and 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