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Emerging evidence shows that gut microbiota critically influences DFUs healing through immune modulation (e.g., Treg\/Th17 balance), regulation of inflammatory responses via short\u2212chain fatty acids (SCFAs) that inhibit NF-\u03baB, the gut-immune-skin axis, and systemic effects of microbial metabolites. Microbiota-targeted interventions-probiotics, prebiotics, fecal microbiota transplantation, and dietary strategies-can restore microbial balance and reduce inflammation, thereby promoting DFUs healing. 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