{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:53:08Z","timestamp":1791175988358,"version":"4.1.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Autoimmune thyroiditis (AIT) has been associated with an increased cardiovascular risk. Whether adipokines, inflammation and auto-immunity contribute to this increased risk is uncertain. Our aim was to evaluate the interrelationships of adipokines, inflammation, auto-immunity, and thyroid function with cardiovascular risk in autoimmune thyroiditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty-two patients with AIT, with normal free T4 (FT4) and free T3 (FT3), without other comorbidities were studied. Patients were divided into two groups: AIT with thyroid-stimulating hormone (TSH) \u22642.5 mU\/L and AIT with TSH &amp;gt;2.5 mU\/L. Parameters of thyroid function tests, serum lipid, high sensitivity C-reactive protein (hs-CRP) and homocysteine levels, anti-thyroglobulin antibodies, anti-thyroid peroxidase (TPO) antibodies, adiponectin and resistin were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with TSH &amp;gt;2.5 mU\/L had significantly higher body mass index, higher low density lipoprotein (LDL)-cholesterol levels, and lower lipoprotein(a) levels. No differences in triglycerides, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), adiponectin, or resistin levels were observed between groups. In the overall cohort, adiponectin levels were positively correlated with high density lipoprotein (HDL)-cholesterol and lipoprotein(a), whereas resistin was positively correlated with hs-CRP and triglyceride levels. Hs-CRP levels were positively correlated with anti-thyroglobulin antibody titers, and homocysteine levels were negatively correlated with FT3. In the subgroup with TSH &amp;gt;2.5 mU\/L, FT4 was positively correlated with ApoA1 and HDL-cholesterol and negatively correlated with lipoprotein(a), while resistin was positively correlated with TSH. In patients with TSH \u22642.5 mU\/L, adiponectin levels were negatively correlated with TSH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study highlights a complex interrelationship between cardiovascular risk factors in patients with AIT. Patients with AIT and TSH &amp;gt;2.5 mU\/L may have a more atherogenic lipid profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1865915","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:37:16Z","timestamp":1791175036000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular risk factors in autoimmune thyroiditis: role of adiponectin, resistin, inflammation and auto-immunity - a cross-sectional study"],"prefix":"10.3389","volume":"17","author":[{"given":"Celestino","family":"Neves","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o","place":["Porto, Portugal"]},{"name":"Faculty of Medicine of University of Porto","place":["Porto, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o S\u00e9rgio","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o","place":["Porto, Portugal"]},{"name":"RISE-Health, Faculty of Medicine, University of Porto","place":["Porto, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Sokhatska","sequence":"additional","affiliation":[{"name":"Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto","place":["Porto, Portugal"]},{"name":"Laboratory of Immunology, Department of Clinical Pathology, Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o","place":["Porto, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Delgado","sequence":"additional","affiliation":[{"name":"RISE-Health, Faculty of Medicine, University of Porto","place":["Porto, Portugal"]},{"name":"Basic and Clinical Immunology, Department of 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