{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:14:08Z","timestamp":1786115648673,"version":"build-2736575974"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individual responses to weight loss interventions are highly heterogeneous. This study aimed to explore the association between serum SULT1A2 and SH2B1 levels and weight loss responses, with the goal of generating biologically relevant hypotheses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The first cohort consisted of 223 patients (102 normal weight, 52 overweight, and 69 obese), to assess associations of baselines SULT1A2 and SH2B1 with weight status. The second cohort included 49 eligible participants that completed a 4-week intermittent fasting-based weight management program. They were divided into greater weight loss group (weight loss \u22655% of initial body weight) and lesser weight loss group (weight loss &amp;lt;5%). Serum SULT1A2 and SH2B1 levels were detected by enzyme-linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the first cohort, serum SULT1A2 and SH2B1 levels varied significantly across BMI groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.013, respectively). Both biomarkers were elevated in the overweight group compared with the normal weight group (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt;\u00a00.01 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05). The obese group had lower SULT1A2 and SH2B1 levels than the overweight group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05), with no significant differences versus the normal weight group. In the second cohort, SULT1A2 exhibited no association with weight loss response across both sexes. For SH2B1, male greater weight loss group exhibited significantly higher levels than lesser weight loss group (2477.1 \u00b1 1332.2 vs. 1298.4 \u00b1 649.6 ng\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.030, Hedges\u2019 g = 0.97, 95% CI: 0.01\u20131.97); however, this association was attenuated and did not persist after multivariable adjustment for age and baseline BMI. In females, no such difference was observed (1325.0 \u00b1 812.3 vs. 1135.7 \u00b1 488.3 ng\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.471, Hedges\u2019 g = 0.25, 95% CI: \u22120.49\u20130.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Circulating SULT1A2 and SH2B1 vary across adiposity phenotypes, suggesting their potential involvement in energy metabolism. Baseline SH2B1 showed a male-specific exploratory association with early weight-loss response, although this finding was not independent of age and BMI. Collectively, these results support SH2B1 as a candidate peripheral marker of further investigation in larger, independent cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1873732","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:24:18Z","timestamp":1785990258000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum SH2B1 and SULT1A2 in relation to adiposity and early weight-loss response: a hypothesis-generating study"],"prefix":"10.3389","volume":"17","author":[{"given":"Haiyan","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University","place":["Linhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Public Health, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University","place":["Linhai, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Ye","sequence":"additional","affiliation":[{"name":"Health Management Centre, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University","place":["Linhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Public Scientific Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University","place":["Linhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University","place":["Linhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University","place":["Linhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","unstructured":"Obesity and overweight\n          \n          \n          2024","DOI":"10.1155\/2024\/9587300"},{"key":"B2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23472","article-title":"Health consequences of obesity and projected future obesity health burden in China","volume":"30","author":"Sun","year":"2022","journal-title":"Obes (Silver Spring Md)"},{"key":"B4","volume-title":"Who European Regional Obesity Report 2022","year":"2022"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/nu13114176","article-title":"Obesity and cardiometabolic risk factors: From childhood to adulthood","volume":"13","author":"Drozdz","year":"2021","journal-title":"Nutrients"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2021.12.010","article-title":"Fatty liver through the ages: Nonalcoholic steatohepatitis","volume":"28","author":"Younossi","year":"2022","journal-title":"Endocrine Practice: Off J Am Coll Endocrinol Am Assoc Clin Endocrinologists"},{"key":"B7","first-page":"51s","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults--the evidence report","volume":"6","year":"1998","journal-title":"Obes Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2012.01.005","article-title":"Successful weight loss among obese U.S. adults","volume":"42","author":"Nicklas","year":"2012","journal-title":"Am J Prev Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.94","article-title":"Long-term weight loss maintenance in the United States","volume":"34","author":"Kraschnewski","year":"2010","journal-title":"Int J Obes (2005)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pcad.2018.12.012","article-title":"Precision medicine in weight loss and healthy living","volume":"62","author":"Severin","year":"2019","journal-title":"Prog Cardiovasc Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.pcad.2018.06.002","article-title":"The contributions of 'diet', 'genes', and physical activity to the etiology of obesity: Contrary evidence and consilience","volume":"61","author":"Archer","year":"2018","journal-title":"Prog Cardiovasc Dis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-27302012000400001","article-title":"The role of the uncoupling protein 1 (Ucp1) on the development of obesity and type 2 diabetes mellitus","volume":"56","author":"Brondani","year":"2012","journal-title":"Arquivos Brasileiros Endocrinologia e Metabologia"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: Global epidemiology and pathogenesis","volume":"15","author":"Bl\u00fcher","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol Cell Proteomics: MCP"},{"key":"B15","doi-asserted-by":"publisher","first-page":"7256","DOI":"10.1038\/s41598-023-34296-4","article-title":"Association of Sult1a2 Rs1059491 with obesity and dyslipidaemia in southern Chinese adults","volume":"13","author":"Lv","year":"2023","journal-title":"Sci Rep"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0687","article-title":"Deletion of the brain-specific A and \u0394 isoforms of adapter protein Sh2b1 protects mice from obesity","volume":"70","author":"Cote","year":"2021","journal-title":"Diabetes"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i4.511","article-title":"Sh2b1 regulation of energy balance, body weight, and glucose metabolism","volume":"5","author":"Rui","year":"2014","journal-title":"World J Diabetes"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00265.2023","article-title":"2022 Cannon Lecture: An ode to signal transduction: How the growth hormone pathway revealed insight into height, Malignancy, and obesity","volume":"325","author":"Carter-Su","year":"2023","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2022.03.016","article-title":"Hereditary severe insulin resistance syndrome: Pathogenesis, pathophysiology, and clinical management","volume":"10","author":"Iqbal","year":"2023","journal-title":"Genes Dis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1159\/000469662","article-title":"Genetic predictors of \u22655% weight loss by multidisciplinary advice to severely obese subjects","volume":"10","author":"Aller","year":"2017","journal-title":"J Nutrigenetics Nutrigenomics"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-014-1190-5","article-title":"Validation study of multi-frequency bioelectrical impedance with dual-energy X-ray absorptiometry among obese patients","volume":"24","author":"Faria","year":"2014","journal-title":"Obes Surg"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.11909\/j.issn.1671-5411.2018.01.011","article-title":"2016 Chinese guidelines for the management of dyslipidemia in adults","volume":"15","year":"2018","journal-title":"J Geriatric Cardiology: JGC"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125660","article-title":"Fine mapping of a GWAS-derived obesity candidate region on chromosome 16p11.2","volume":"10","author":"Volckmar","year":"2015","journal-title":"PloS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/oby.23046","article-title":"Coding variants are relevant to the expression of obesity-related genes for pediatric adiposity","volume":"29","author":"Mao","year":"2021","journal-title":"Obes (Silver Spring Md)"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400437","article-title":"Sh2b1 defends against energy imbalance, obesity, and metabolic disease via a paraventricular hypothalamus\u2192dorsal raphe nucleus neurocircuit","volume":"11","author":"Li","year":"2024","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.11817\/j.issn.1672-7347.2014.01.008","article-title":"Expression change of Sh2b1, Socs3, Ptp1b and Npy in mice hypothalamus and its relation with obesity","volume":"39","author":"Su","year":"2014","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban = J Cent South Univ Med Sci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1038\/s41467-020-15328-3","article-title":"Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease","volume":"11","author":"Jiang","year":"2020","journal-title":"Nat Commun"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1159\/000520402","article-title":"Genetic obesity in children: Overview of possible diagnoses with a focus on Sh2b1 deletion","volume":"95","author":"Giannopoulou","year":"2022","journal-title":"Hormone Res Paediatrics"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101155","article-title":"Chromosomal deletions on 16p11.2 encompassing Sh2b1 are associated with accelerated metabolic disease","volume":"4","author":"Hanssen","year":"2023","journal-title":"Cell Rep Med"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030639","article-title":"Key genes of lipid metabolism and Wnt-signaling are downregulated in subcutaneous adipose tissue with moderate weight loss","volume":"11","author":"Sch\u00fcbel","year":"2019","journal-title":"Nutrients"},{"key":"B31","doi-asserted-by":"publisher","first-page":"6903","DOI":"10.1038\/s41467-023-42682-9","article-title":"Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis","volume":"14","author":"\u00c5kesson","year":"2023","journal-title":"Nat Commun"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqad032","article-title":"Role of the beta and gamma isoforms of the adapter protein Sh2b1 in regulating energy balance","volume":"164","author":"Argetsinger","year":"2023","journal-title":"Endocrinology"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1333051","article-title":"Sex dimorphism in the effect and predictors of weight loss after sleeve gastrectomy","volume":"14","author":"Shu","year":"2023","journal-title":"Front Endocrinol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1274662","article-title":"Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss","volume":"10","author":"Mera-Charria","year":"2023","journal-title":"Front Nutr"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-020-02476-x","article-title":"Differential response to a 6-month energy-restricted treatment depending on Sh2b1 Rs7359397 variant in NAFLD subjects: Fatty liver in obesity (FLIO) study","volume":"60","author":"Perez-Diaz-Del-Campo","year":"2021","journal-title":"Eur J Nutr"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000368425","article-title":"Sh2b1 Cpg-Snp is associated with body weight reduction in obese subjects following a dietary restriction program","volume":"66","author":"Mansego","year":"2015","journal-title":"Ann Nutr Metab"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2025.2478068","article-title":"A case-control study on Sh2b1 gene variants in obesity and obstructive sleep apnea severity: Genetic risk factors in the leptin signaling pathway","volume":"20","author":"Kuccukturk","year":"2025","journal-title":"Expert Rev Endocrinol Metab"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1873732\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:24:24Z","timestamp":1785990264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1873732\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":37,"alternative-id":["10.3389\/fendo.2026.1873732"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1873732","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"article-number":"1873732"}}