{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:59:42Z","timestamp":1785387582119,"version":"3.55.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"\n Background<\/jats:title>\n The triglyceride\u2013glucose (TyG) index, a surrogate marker of insulin resistance, has been associated with outcomes in sepsis, but existing evidence is inconsistent. This meta-analysis aimed to evaluate the association between a high TyG index and short-term mortality in adult patients with sepsis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A systematic search of PubMed, Embase, Web of Science, Wanfang, and CNKI was conducted to identify observational studies reporting the association between TyG index and short-term mortality (in-hospital or \u226430-day) in adult sepsis patients. Effect estimates were pooled using a random-effects model accounting for the influence of heterogeneity.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eight retrospective cohort studies involving 14,772 patients were included. Overall, a higher TyG index was associated with increased short-term mortality (odds ratio [OR] 1.72, 95% confidence intervals 1.44\u20132.04; I\u00b2 = 53%). Subgroup analyses showed consistent associations across mean age, proportion of men, and diabetic status (non-diabetic vs. mixed populations:\n p<\/jats:italic>\n for subgroup difference all &gt; 0.05). The association remained significant regardless of cutoff determination methods, cutoff values, outcome type (in-hospital vs. 28-day mortality), and study quality scores (\n p<\/jats:italic>\n for subgroup difference all &gt; 0.05). Meta-regression analyses did not suggest the association was significantly modified by mean age, proportion of men, proportion of diabetic patients, cutoff values of TyG index, or study quality scores (\n p<\/jats:italic>\n all &gt; 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A higher TyG index is associated with an increased risk of short-term mortality in adult patients with sepsis, supporting its potential role as a simple prognostic marker in clinical practice.<\/jats:p>\n <\/jats:sec>\n \n Systematic Review Registration<\/jats:title>\n \n https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>\n , identifier CRD420261389660.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fendo.2026.1875452","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:22:14Z","timestamp":1785385334000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Triglyceride-glucose index and short-term mortality of adult patients with sepsis: a meta-analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Weijie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of ICU, First People\u2019s Hospital of Daishan County","place":["Zhoushan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of ICU, First People\u2019s Hospital of Daishan County","place":["Zhoushan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of ICU, First People\u2019s Hospital of Daishan County","place":["Zhoushan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of ICU, First People\u2019s Hospital of Daishan County","place":["Zhoushan, 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