{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:03:38Z","timestamp":1785488618676,"version":"3.56.0"},"reference-count":235,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Diabetic kidney disease (DKD), with the high prevalence of diabetes mellitus, has become the primary cause of end-stage renal disease. Tubular injury is one of the earliest characteristic changes and serves as a significant driving factor of renal function loss in DKD. Under physiological conditions, regulated cell death (RCD) preserves renal homeostasis by eliminating damaged tubular epithelial cells. Emerging evidence has demonstrated that abnormal RCD of tubular epithelial cells aggravates the development of DKD. Our review intends to elucidate recent discoveries regarding the pathogenetic role of the most studied RCD, such as apoptosis, necroptosis, pyroptosis, ferroptosis and autophagy, in DKD, and provide a theoretical foundation for future investigations as well as targeted drug design.<\/jats:p>","DOI":"10.3389\/fendo.2026.1877238","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:53:05Z","timestamp":1785487985000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tubular injury in diabetic kidney disease: a focus on regulated cell death"],"prefix":"10.3389","volume":"17","author":[{"given":"Hongwei","family":"Sun","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People\u2019s Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), School of Bioengineering, Zunyi Medical University","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, 900th Affiliated Hospital of People's Liberation Army of China (PLA)","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00393-8","article-title":"Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors","volume":"17","author":"DeFronzo","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.28996\/2618-9801-2023-2-141-221","article-title":"KDIGO 2022 clinical practice guideline for diabetes management in chronic kidney disease","volume":"102","year":"2022","journal-title":"Kidney Int"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0027","article-title":"Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"45","author":"de Boer","year":"2022","journal-title":"Diabetes Care"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/cells11203236","article-title":"The contribution of lipotoxicity to diabetic kidney disease","volume":"11","author":"Schelling","year":"2022","journal-title":"Cells"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fcdhc.2025.1718498","article-title":"The effect of HbA1C variability on the development and progression of diabetic nephropathy","volume":"6","author":"Coskun","year":"2025","journal-title":"Front Clin Diabetes Healthc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1186\/s12882-025-04546-w","article-title":"The relationship between serum lipid levels and diabetic nephropathy in patients with primary diabetes","volume":"26","author":"Wang","year":"2025","journal-title":"BMC Nephrol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/s12916-022-02537-4","article-title":"From screening to treatment: the new landscape of diabetic kidney disease","volume":"20","author":"Cervantes","year":"2022","journal-title":"BMC Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.05.012","article-title":"Molecular mechanisms and therapeutic targets for diabetic kidney disease","volume":"102","author":"Tuttle","year":"2022","journal-title":"Kidney Int"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0256-y","article-title":"The tubular hypothesis of nephron filtration and diabetic kidney disease","volume":"16","author":"Vallon","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00689-6","article-title":"A guide to cell death pathways","volume":"25","author":"Yuan","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-2776(01)76020-8","article-title":"Cell death","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s545938","article-title":"Programmed cell death in diabetic kidney disease: mechanisms and therapeutic targeting","volume":"18","author":"Tang","year":"2025","journal-title":"J Inflammation Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.kint.2022.02.038","article-title":"Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells","volume":"102","author":"Xie","year":"2022","journal-title":"Kidney Int"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154334","article-title":"Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK\/SP1\/PGAM5 pathway","volume":"111","author":"Liu","year":"2020","journal-title":"Metabolism"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2023.2292753","article-title":"CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function","volume":"45","author":"Niu","year":"2023","journal-title":"Ren Fail"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-023-02145-5","article-title":"METTL14 promotes the development of diabetic kidney disease by regulating m(6)A modification of TUG1","volume":"60","author":"Zheng","year":"2023","journal-title":"Acta Diabetol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s10020-023-00651-4","article-title":"ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response","volume":"29","author":"Liu","year":"2023","journal-title":"Mol Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115641","article-title":"Mitochondrial protease ClpP deficiency protects against tubulointerstitial damage in diabetic kidney disease","volume":"166","author":"Wang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1042\/cs20200005","article-title":"DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease","volume":"134","author":"Gao","year":"2020","journal-title":"Clin Sci (Lond)"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200488r","article-title":"Exosomes derived from mesenchymal stem cells attenuate diabetic kidney disease by inhibiting cell apoptosis and epithelial-to-mesenchymal transition via miR-424-5p","volume":"36","author":"Cui","year":"2022","journal-title":"FASEB J"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20192384","article-title":"MicroRNA-140-5p ameliorates the high glucose-induced apoptosis and inflammation through suppressing TLR4\/NF-\u03baB signaling pathway in human renal tubular epithelial cells","volume":"40","author":"Su","year":"2020","journal-title":"Biosci Rep"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202500106R","article-title":"HNF4A regulated APEH deficiency promotes UPR activation in diabetic kidney disease","volume":"39","author":"Wang","year":"2025","journal-title":"FASEB J"},{"key":"B25","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.kint.2025.07.023","article-title":"Protein UHRF1-mediated dual dysregulation of molecular chaperone GRP78 induces endoplasmic reticulum stress and aggravates diabetic nephropathy","volume":"108","author":"Yang","year":"2025","journal-title":"Kidney Int"},{"key":"B26","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s10020-025-01320-4","article-title":"Pyruvate kinase M2 activation maintains mitochondrial metabolism by regulating the interaction between HIF-1\u03b1 and PGC-1\u03b1 in diabetic kidney disease","volume":"31","author":"Park","year":"2025","journal-title":"Mol Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s10753-025-02362-w","article-title":"ZBP1 mediates renal tubular injury in diabetic nephropathy through RIPK3-mediated necroptosis","volume":"49","author":"Hu","year":"2026","journal-title":"Inflammation"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-026-01737-9","article-title":"Keratin 18 functions as a lactyltransferase to trigger necroptosis in diabetic kidney disease by modulating Fas transcription","volume":"58","author":"Zhao","year":"2026","journal-title":"Exp Mol Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2026015","article-title":"P300-mediated H3K18 acetylation triggers necroptosis via modulation of KRT18 transcription in diabetic nephropathy","volume":"58","author":"Zhao","year":"2026","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.83906","article-title":"PTEN-induced kinase 1 exerts protective effects in diabetic kidney disease by attenuating mitochondrial dysfunction and necroptosis","volume":"19","author":"Sung","year":"2023","journal-title":"Int J Biol Sci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114562","article-title":"Targeting inflammation and necroptosis in diabetic kidney disease: a novel approach via PPAR\u03b1 modulation","volume":"154","author":"Wang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-021-01736-4","article-title":"Klotho protects against diabetic kidney disease via AMPK- and ERK-mediated autophagy","volume":"58","author":"Xue","year":"2021","journal-title":"Acta Diabetol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s41419-023-06175-3","article-title":"PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy","volume":"14","author":"Yang","year":"2023","journal-title":"Cell Death Dis"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1962681","article-title":"Vitamin D-VDR (vitamin D receptor) regulates defective autophagy in renal tubular epithelial cell in streptozotocin-induced diabetic mice via the AMPK pathway","volume":"18","author":"Li","year":"2022","journal-title":"Autophagy"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.109799","article-title":"SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy\u2013lysosome pathway","volume":"21","author":"Zheng","year":"2025","journal-title":"Int J Biol Sci"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2601874","article-title":"ESRRA-ATG5-mediated mitophagy enhances arginine metabolism to alleviate diabetic kidney disease","volume":"22","author":"Hu","year":"2026","journal-title":"Autophagy"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2025h7he3fr5","article-title":"GSTK1 and RETREG1\/FAM134B-mediated reticulophagy attenuates tubular injury in diabetic nephropathy through endoplasmic reticulum stress and apoptosis","volume":"21","author":"Zhang","year":"2025","journal-title":"Autophagy"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2024.2338933","article-title":"TXNIP deficiency attenuates renal fibrosis by modulating mTORC1\/TFEB-mediated autophagy in diabetic kidney disease","volume":"46","author":"Du","year":"2024","journal-title":"Ren Fail"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118686","article-title":"ATF4 promotes renal tubulointerstitial fibrosis by suppressing autophagy in diabetic nephropathy","volume":"264","author":"Liang","year":"2021","journal-title":"Life Sci"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101089","article-title":"P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response","volume":"42","author":"Dusabimana","year":"2020","journal-title":"Mol Metab"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1824694","article-title":"SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy","volume":"17","author":"Yang","year":"2021","journal-title":"Autophagy"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2581214","article-title":"XIAP-ULK1-mediated mitophagy modulates carnitine metabolism to mitigate diabetic kidney disease","volume":"22","author":"Hu","year":"2026","journal-title":"Autophagy"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-026-00953-5","article-title":"AARS1 promotes diabetic kidney disease through rewiring Akt and NF-\u03baB signaling to suppress autophagy and sustain inflammation","author":"Tian","year":"2026","journal-title":"Cell Mol Biol Lett"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-023-00416-7","article-title":"Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway","volume":"56","author":"Cui","year":"2023","journal-title":"Biol Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112293","article-title":"Endoplasmic reticulum stress related factor IRE1\u03b1 regulates TXNIP\/NLRP3-mediated pyroptosis in diabetic nephropathy","volume":"396","author":"Ke","year":"2020","journal-title":"Exp Cell Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12967-023-04846-5","article-title":"(Pro)renin receptor mediates tubular epithelial cell pyroptosis in diabetic kidney disease via DPP4-JNK pathway","volume":"22","author":"Xie","year":"2024","journal-title":"J Transl Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70337","article-title":"Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis","volume":"15","author":"Huang","year":"2025","journal-title":"Clin Transl Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1620230","article-title":"SGLT2 inhibition attenuates diabetic tubulopathy by suppressing SGK1-mediated pyroptosis","volume":"16","author":"Shi","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115911","article-title":"HPGDS promotes tubular injury and interstitial inflammation in diabetic nephropathy by activating canonical pyroptosis pathway","volume":"168","author":"Huang","year":"2026","journal-title":"Int Immunopharmacol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2026.118200","article-title":"Dapagliflozin ameliorates diabetic kidney disease by inhibiting oxidative stress and AIM2-dependent pyroptosis via SIRT1 activation","volume":"251","author":"Wang","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167645","article-title":"PDIA4 targets IRE1\u03b1\/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease","volume":"1871","author":"Liu","year":"2025","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-023-09790-0","article-title":"Syringaresinol protects against diabetic nephropathy by inhibiting pyroptosis via NRF2-mediated antioxidant pathway","volume":"39","author":"Li","year":"2023","journal-title":"Cell Biol Toxicol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5584894","article-title":"Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p\/Caspase1 Signaling Pathway in Diabetic Nephropathy","volume":"2023","author":"Zheng","year":"2023","journal-title":"Stem Cells Int"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.12.006","article-title":"Long noncoding RNA MALAT1 regulates renal tubular epithelial pyroptosis by modulated miR-23c targeting of ELAVL1 in diabetic nephropathy","volume":"350","author":"Li","year":"2017","journal-title":"Exp Cell Res"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.04.062","article-title":"Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose","volume":"610","author":"Han","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B56","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41418-025-01587-4","article-title":"AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy","volume":"33","author":"Hong","year":"2026","journal-title":"Cell Death Differ"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfac034","article-title":"ZIP14 is involved in iron deposition and triggers ferroptosis in diabetic nephropathy","volume":"14","author":"Wu","year":"2022","journal-title":"Metallomics"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-024-01357-8","article-title":"The PRMT6\/STAT1\/ACSL1 axis promotes ferroptosis in diabetic nephropathy","volume":"31","author":"Hong","year":"2024","journal-title":"Cell Death Differ"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116102","article-title":"STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease","volume":"222","author":"Zhao","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41420-024-02179-w","article-title":"C\/EBP\u03b1-mediated ACSL4-dependent ferroptosis exacerbates tubular injury in diabetic kidney disease","volume":"10","author":"Xia","year":"2024","journal-title":"Cell Death Discov"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416441","article-title":"CNPY2 aggravates renal tubular cell ferroptosis in diabetic nephropathy by regulating PERK\/ATF4\/CHAC1 pathway and MAM integrity","volume":"12","author":"Chen","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.10.323","article-title":"Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy","volume":"162","author":"Li","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"B63","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2022.12.088","article-title":"Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK\/NRF2 pathway","volume":"195","author":"Lu","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2024.2377785","article-title":"Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2\/GPX4 pathway","volume":"46","author":"Du","year":"2024","journal-title":"Ren Fail"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305563","article-title":"VDR activation attenuates renal tubular epithelial cell ferroptosis by regulating nrf2\/HO-1 signaling pathway in diabetic nephropathy","volume":"11","author":"Wang","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2025.2458761","article-title":"USP9X suppresses ferroptosis in diabetic kidney disease by deubiquitinating Nrf2 in vitro","volume":"47","author":"Shao","year":"2025","journal-title":"Ren Fail"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.05.024","article-title":"NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2\/Gpx4 pathway","volume":"187","author":"Li","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"B68","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1","volume":"11","author":"Xiao","year":"2017","journal-title":"Redox Biol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2025034","article-title":"Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease","volume":"57","author":"Chen","year":"2025","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3596","article-title":"Role of renal tubular programed cell death in diabetic kidney disease","volume":"39","author":"Zhou","year":"2023","journal-title":"Diabetes Metab Res Rev"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167022","article-title":"IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy","volume":"1870","author":"Yuan","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102855","article-title":"DsbA-L interacting with catalase in peroxisome improves tubular oxidative damage in diabetic nephropathy","volume":"66","author":"Liu","year":"2023","journal-title":"Redox Biol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ebiom.2019.09.002","article-title":"FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease","volume":"48","author":"Huang","year":"2019","journal-title":"EBioMedicine"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2713864","article-title":"High glucose-induced kidney injury via activation of necroptosis in diabetic kidney disease","volume":"2023","author":"Guo","year":"2023","journal-title":"Oxid Med Cell Longev"},{"key":"B75","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s10020-021-00285-4","article-title":"IL-17 deficiency aggravates the streptozotocin-induced diabetic nephropathy through the reduction of autophagosome formation in mice","volume":"27","author":"Kim","year":"2021","journal-title":"Mol Med"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173449","article-title":"Geniposide alleviates diabetic nephropathy of mice through AMPK\/SIRT1\/NF-\u03baB pathway","volume":"886","author":"Li","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41420-023-01452-8","article-title":"GSDME-dependent pyroptosis signaling pathway in diabetic nephropathy","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051516","article-title":"Punicalagin protects diabetic nephropathy by inhibiting pyroptosis based on TXNIP\/NLRP3 pathway","volume":"12","author":"An","year":"2020","journal-title":"Nutrients"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-025-06612-2","article-title":"Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease","volume":"69","author":"Matsui","year":"2026","journal-title":"Diabetologia"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2024.2327495","article-title":"Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats","volume":"46","author":"Zhang","year":"2024","journal-title":"Ren Fail"},{"key":"B81","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/s41419-021-03452-x","article-title":"Characterization of ferroptosis in kidney tubular cell death under diabetic conditions","volume":"12","author":"Kim","year":"2021","journal-title":"Cell Death Dis"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114786","article-title":"PINK1 affects mitochondrial oxidative phosphorylation by regulating MFN2 to alleviate diabetic kidney disease","volume":"157","author":"Pei","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s41419-023-05685-4","article-title":"The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation","volume":"14","author":"Xu","year":"2023","journal-title":"Cell Death Dis"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1159\/000529995","article-title":"Nephropathy is aggravated by fatty acids in diabetic kidney disease through tubular epithelial cell necroptosis and is alleviated by an RIPK-1 inhibitor","volume":"9","author":"Yu","year":"2023","journal-title":"Kidney Dis (Basel)"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/s41419-021-04326-y","article-title":"Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy","volume":"12","author":"Han","year":"2021","journal-title":"Cell Death Dis"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00603","article-title":"TLR4\/NF-\u03baB signaling induces GSDMD-related pyroptosis in tubular cells in diabetic kidney disease","volume":"10","author":"Wang","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107306","article-title":"Apabetalone, a BET protein inhibitor, inhibits kidney damage in diabetes by preventing pyroptosis via modulating the P300\/H3K27ac\/PLK1 axis","volume":"207","author":"Wang","year":"2024","journal-title":"Pharmacol Res"},{"key":"B88","doi-asserted-by":"publisher","first-page":"10458","DOI":"10.1038\/s41598-020-67054-x","article-title":"RIPK3 blockade attenuates tubulointerstitial fibrosis in a mouse model of diabetic nephropathy","volume":"10","author":"Shi","year":"2020","journal-title":"Sci Rep"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01554-0","article-title":"Calcitriol attenuates renal tubular epithelial cells apoptosis via inhibiting p38MAPK signaling in diabetic nephropathy","volume":"57","author":"Guo","year":"2020","journal-title":"Acta Diabetol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061457","article-title":"Dapagliflozin restores impaired autophagy and suppresses inflammation in high glucose-treated HK-2 cells","volume":"10","author":"Xu","year":"2021","journal-title":"Cells"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.072","article-title":"Astilbin inhibits high glucose-induced autophagy and apoptosis through the PI3K\/Akt pathway in human proximal tubular epithelial cells","volume":"106","author":"Chen","year":"2018","journal-title":"BioMed Pharmacother"},{"key":"B92","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1089\/ars.2022.0169","article-title":"Dapagliflozin alleviates diabetic kidney disease via hypoxia inducible factor 1\u03b1\/heme oxygenase 1-mediated ferroptosis","volume":"40","author":"Wang","year":"2024","journal-title":"Antioxid Redox Signal"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.049","article-title":"Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis","volume":"108","author":"Chen","year":"2018","journal-title":"BioMed Pharmacother"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.05.070","article-title":"Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy","volume":"463","author":"Xin","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111282","article-title":"PDK4-mediated Nrf2 inactivation contributes to oxidative stress and diabetic kidney injury","volume":"121","author":"Tian","year":"2024","journal-title":"Cell Signal"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00098.2020","article-title":"Nonesterified free fatty acids enhance the inflammatory response in renal tubules by inducing extracellular ATP release","volume":"319","author":"Sun","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"293","DOI":"10.21037\/atm.2020.02.172","article-title":"Inhibiting PKC\u03b22 protects HK-2 cells against meglumine diatrizoate and AGEs-induced apoptosis and autophagy","volume":"8","author":"Jiang","year":"2020","journal-title":"Ann Transl Med"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.hkjn.2015.08.036","article-title":"Autophagy-lysosome pathway in renal tubular epithelial cells is disrupted by advanced glycation end products in diabetic nephropathy","volume":"290","author":"Liu","year":"2015","journal-title":"J Biol Chem"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.08.042","article-title":"Differential impact of glucose levels and advanced glycation end-products on tubular cell viability and pro-inflammatory\/profibrotic functions","volume":"451","author":"Franko","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20180992","article-title":"Apoptosis and apoptotic body: disease message and therapeutic target potentials","volume":"39","author":"Xu","year":"2019","journal-title":"Biosci Rep"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1042\/bcj20210854","article-title":"The concept of intrinsic versus extrinsic apoptosis","volume":"479","author":"Lossi","year":"2022","journal-title":"Biochem J"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3390\/cells13221838","article-title":"Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications","volume":"13","author":"Mustafa","year":"2024","journal-title":"Cells"},{"key":"B103","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41392-025-02176-0","article-title":"The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy","volume":"10","author":"Vogler","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"B104","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03433-5","article-title":"A review on caspases: key regulators of biological activities and apoptosis","volume":"60","author":"Sahoo","year":"2023","journal-title":"Mol Neurobiol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041020","article-title":"Caspase activation and inhibition","volume":"14","author":"Green","year":"2022","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17111868","article-title":"Stearoyl-CoA desaturase-1 protects cells against lipotoxicity-mediated apoptosis in proximal tubular cells","volume":"17","author":"Iwai","year":"2016","journal-title":"Int J Mol Sci"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12909","article-title":"HIF-1alpha ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics","volume":"53","author":"Jiang","year":"2020","journal-title":"Cell Prolif"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.05.431","article-title":"Mito-tempo ameliorates tubular injury of diabetic nephropathy via inhibiting mt-dsRNA release and PKR\/eIF2alpha pathway activation","volume":"237","author":"Duan","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"B110","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ceca.2017.05.003","article-title":"Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death","volume":"69","author":"Marchi","year":"2018","journal-title":"Cell Calcium"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081144","article-title":"Mitochondrial redox signaling and oxidative stress in kidney diseases","volume":"11","author":"Aranda-Rivera","year":"2021","journal-title":"Biomolecules"},{"key":"B112","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/s41419-021-03813-6","article-title":"CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys","volume":"12","author":"Hou","year":"2021","journal-title":"Cell Death Dis"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu Rev Immunol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102946","article-title":"Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via PI3K\/Akt\/eNOS signaling pathway in diabetic tubulopathy","volume":"68","author":"Yao","year":"2023","journal-title":"Redox Biol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202501993r","article-title":"Human umbilical cord mesenchymal stem cells reduce renal tubular epithelial cell apoptosis by regulating the Wnt\/beta-catenin pathway in diabetic nephropathy","volume":"39","author":"Guan","year":"2025","journal-title":"FASEB J"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-019-0314-9","article-title":"Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK\/Bim pathway","volume":"41","author":"Zhang","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.70136","article-title":"Cycloastragenol regulates mitochondrial homeostasis-mediated renal tubular injury to ameliorate diabetic kidney disease by directly targeting ERK to modulate TFEB","volume":"40","author":"Gao","year":"2026","journal-title":"Phytother Res"},{"key":"B118","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.molcel.2012.12.026","article-title":"The tangled circuitry of metabolism and apoptosis","volume":"49","author":"Andersen","year":"2013","journal-title":"Mol Cell"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-06078-0","article-title":"Canagliflozin regulates metabolic reprogramming in diabetic kidney disease by inducing fasting-like and aestivation-like metabolic patterns","volume":"67","author":"Shao","year":"2024","journal-title":"Diabetologia"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119398","article-title":"Boeravinone C ameliorates lipid accumulation and inflammation in diabetic kidney disease by activating PPARalpha signaling","volume":"342","author":"Cheng","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3390\/biom15070995","article-title":"Inhibiting miR-200a-3p increases sirtuin 1 and mitigates kidney injury in a tubular cell model of diabetes and hypertension-related renal damage","volume":"15","author":"Martinez-Arroyo","year":"2025","journal-title":"Biomolecules"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1426854","article-title":"ER-alpha36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell","volume":"16","author":"Yu","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.178373","article-title":"Circulating proteins linked to apoptosis processes and fast development of end-stage kidney disease in diabetes","volume":"9","author":"Ihara","year":"2024","journal-title":"JCI Insight"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.239","article-title":"Inhibition of SGLT2 alleviates diabetic nephropathy by suppressing high glucose-induced oxidative stress in type 1 diabetic mice","volume":"4","author":"Hatanaka","year":"2016","journal-title":"Pharmacol Res Perspect"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.06.020","article-title":"SGLT2 inhibition mediates protection from diabetic kidney disease by promoting ketone body-induced mTORC1 inhibition","volume":"32","author":"Tomita","year":"2020","journal-title":"Cell Metab"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2022.2069966","article-title":"The therapeutic prospect of zinc oxide nanoparticles in experimentally induced diabetic nephropathy","volume":"11","author":"Abd El-Baset","year":"2023","journal-title":"Tissue Barriers"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23430","article-title":"Promising renoprotective effect of gold nanoparticles and dapagliflozin in diabetic nephropathy via targeting miR-192 and miR-21","volume":"37","author":"Al-Tantawy","year":"2023","journal-title":"J Biochem Mol Toxicol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8227","article-title":"Quercetin prevented diabetic nephropathy by inhibiting renal tubular epithelial cell apoptosis via the PI3K\/AKT pathway","volume":"38","author":"Liu","year":"2024","journal-title":"Phytother Res"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156411","article-title":"Mitochondria-dependent apoptosis was involved in the alleviation of Jujuboside A on diabetic kidney disease-associated renal tubular injury via YY1\/PGC-1alpha signaling","volume":"138","author":"Yang","year":"2025","journal-title":"Phytomedicine"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114190","article-title":"Cornuside as a promising therapeutic agent for diabetic kidney disease: targeting regulation of Ca(2+) disorder-mediated renal tubular epithelial cells apoptosis","volume":"149","author":"Gao","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B131","doi-asserted-by":"publisher","first-page":"117863","DOI":"10.2139\/ssrn.4653984","article-title":"JinChan YiShen TongLuo formula ameliorate mitochondrial dysfunction and apoptosis in diabetic nephropathy through the HIF-1alpha-PINK1-Parkin pathway","volume":"328","author":"Qiyan","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00694-0","article-title":"Regulated cell death pathways in kidney disease","volume":"19","author":"Sanz","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.108","article-title":"The role of necroptosis in disease and treatment","volume":"2","author":"Liu","year":"2021","journal-title":"MedComm (2020)"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00658-w","article-title":"Role of necroptosis in kidney health and disease","volume":"19","author":"Kolbrink","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107780","article-title":"Identification and analysis of diverse cell death patterns in diabetic kidney disease using microarray-based transcriptome profiling and single-nucleus RNA sequencing","volume":"169","author":"Luo","year":"2024","journal-title":"Comput Biol Med"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.835879","article-title":"Excessive activation of Notch signaling in macrophages promote kidney inflammation, fibrosis, and necroptosis","volume":"13","author":"Ma","year":"2022","journal-title":"Front Immunol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2026.117775","article-title":"EP3 promotes macrophage M1-polarization to play a critical role in diabetic renal injury","volume":"247","author":"Chen","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41392-023-01410-x","article-title":"SARS-CoV-2 N protein induces acute kidney injury in diabetic mice via the Smad3-Ripk3\/MLKL necroptosis pathway","volume":"8","author":"Liang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13810","article-title":"Cassia auriculata leaf extract ameliorates diabetic nephropathy by attenuating autophagic necroptosis via RIP-1\/RIP-3-p-p38MAPK signaling","volume":"45","author":"Al Shahrani","year":"2021","journal-title":"J Food Biochem"},{"key":"B140","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis"},{"key":"B141","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological functions of autophagy genes: a disease perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"B142","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41580-022-00529-z","article-title":"The emerging mechanisms and functions of microautophagy","volume":"24","author":"Wang","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0001-6","article-title":"The coming of age of chaperone-mediated autophagy","volume":"19","author":"Kaushik","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1080\/15548627.2020.1725377","article-title":"Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles","volume":"17","author":"Yao","year":"2021","journal-title":"Autophagy"},{"key":"B145","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41581-020-0309-2","article-title":"Autophagy in kidney homeostasis and disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"B146","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s41419-022-04593-3","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00551-9","article-title":"Autophagy in metabolic disease and ageing","volume":"17","author":"Kitada","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1681\/asn.20203110s133c","article-title":"p53\/microRNA-214\/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease","volume":"130","author":"Ma","year":"2020","journal-title":"J Clin Invest"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy in human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat Metab"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2025.10.009","article-title":"Mitochondrial protein TOMM7 alleviates diabetic kidney disease by regulating mitophagy via intracellular redistribution of phospholipase PLA2G6","volume":"109","author":"Wang","year":"2026","journal-title":"Kidney Int"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801749rrr","article-title":"Optineurin inhibits NLRP3 inflammasome activation by enhancing mitophagy of renal tubular cells in diabetic nephropathy","volume":"33","author":"Chen","year":"2019","journal-title":"FASEB J"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2025.102595","article-title":"Autophagy regulation by signaling","volume":"97","author":"Rusten","year":"2025","journal-title":"Curr Opin Cell Biol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2024.06.010","article-title":"Autophagy and lysosomal dysfunction in diabetes and its complications","volume":"35","author":"Arden","year":"2024","journal-title":"Trends Endocrinol Metab"},{"key":"B154","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/s41419-021-04184-8","article-title":"AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice","volume":"12","author":"Han","year":"2021","journal-title":"Cell Death Dis"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00195.2019","article-title":"Glucagon-like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of rapamycin pathway","volume":"319","author":"Yang","year":"2020","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2410621","article-title":"Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules","volume":"21","author":"Matsui","year":"2025","journal-title":"Autophagy"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156901","article-title":"Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy","volume":"143","author":"Ai","year":"2025","journal-title":"Phytomedicine"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157668","article-title":"Swietenine attenuates renal tubular injury by activating mitophagy in diabetic nephropathy","volume":"150","author":"Pei","year":"2026","journal-title":"Phytomedicine"},{"key":"B159","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00662-0","article-title":"Gasdermins and pyroptosis in the kidney","volume":"19","author":"Elias","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-025-01107-6","article-title":"Pyroptosis: molecular mechanisms and roles in disease","volume":"35","author":"Broz","year":"2025","journal-title":"Cell Res"},{"key":"B162","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.cell.2024.11.021","article-title":"How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot","volume":"188","author":"Sahoo","year":"2025","journal-title":"Cell"},{"key":"B163","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-024-01958-2","article-title":"Pyroptosis in health and disease: mechanisms, regulation and clinical perspective","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.002","article-title":"Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.998574","article-title":"NLRP3-mediated pyroptosis in diabetic nephropathy","volume":"13","author":"Wan","year":"2022","journal-title":"Front Pharmacol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s11658-022-00350-8","article-title":"WTAP-mediated N(6)-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy","volume":"27","author":"Lan","year":"2022","journal-title":"Cell Mol Biol Lett"},{"key":"B167","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41387-021-00175-y","article-title":"Serum exosomes from diabetic kidney disease patients promote pyroptosis and oxidative stress through the miR-4449\/HIC1 pathway","volume":"11","author":"Gao","year":"2021","journal-title":"Nutr Diabetes"},{"key":"B168","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/jdi.13660","article-title":"VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation","volume":"13","author":"Wen","year":"2022","journal-title":"J Diabetes Investig"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.2147\/dmso.s515034","article-title":"Inhibition of Caspase-3\/GSDME pathway-mediated pyroptosis of renal tubular epithelial cells by Dagliflozin in the pathogenesis of diabetic kidney disease and study of its mechanism","volume":"18","author":"Jiang","year":"2025","journal-title":"Diabetes Metab Syndr Obes"},{"key":"B170","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s10495-026-02282-6","article-title":"Berberine inhibits ISG15 and pyroptosis to attenuate diabetic kidney disease inflammation and fibrosis","volume":"31","author":"Huang","year":"2026","journal-title":"Apoptosis"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x2550034x","article-title":"Ginsenoside Rg2 alleviates HFD\/STZ-induced diabetic nephropathy by inhibiting pyroptosis via NF-kappaB\/NLRP3 signaling pathways","volume":"53","author":"Li","year":"2025","journal-title":"Am J Chin Med"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7993","article-title":"Hyperoside mediates protection from diabetes kidney disease by regulating ROS-ERK signaling pathway and pyroptosis","volume":"37","author":"Zhang","year":"2023","journal-title":"Phytother Res"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112998","article-title":"Pyrroloquinoline quinone ameliorates renal fibrosis in diabetic nephropathy by inhibiting the pyroptosis pathway in C57BL\/6 mice and human kidney 2 cells","volume":"150","author":"Qu","year":"2022","journal-title":"BioMed Pharmacother"},{"key":"B174","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13098-025-02045-4","article-title":"Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis","volume":"18","author":"Yu","year":"2025","journal-title":"Diabetol Metab Syndr"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110640","article-title":"Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis","volume":"382","author":"Kong","year":"2023","journal-title":"Chem Biol Interact"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154775","article-title":"Zuogui-Jiangtang-Yishen decoction prevents diabetic kidney disease: Intervene pyroptosis induced by trimethylamine n-oxide through the mROS-NLRP3 axis","volume":"114","author":"Yi","year":"2023","journal-title":"Phytomedicine"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.623489","article-title":"Tangshen Formula attenuates diabetic kidney injury by imparting anti-pyroptotic effects via the TXNIP-NLRP3-GSDMD axis","volume":"11","author":"Li","year":"2020","journal-title":"Front Pharmacol"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2020.5973","article-title":"Non-coding RNA and diabetic kidney disease","volume":"40","author":"Ren","year":"2021","journal-title":"DNA Cell Biol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1042\/cs20190372","article-title":"Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease","volume":"133","author":"Guo","year":"2019","journal-title":"Clin Sci (Lond)"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12226","article-title":"LncRNA MALAT1 promoted high glucose-induced pyroptosis of renal tubular epithelial cell by sponging miR-30c targeting for NLRP3","volume":"36","author":"Liu","year":"2020","journal-title":"Kaohsiung J Med Sci"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-025-02295-4","article-title":"LncRNA SNHG7\/miR-181b-5p\/TLR4 activates inflammation and promotes pyroptosis through NF-kappaB signaling in diabetic nephropathy","volume":"48","author":"Zhang","year":"2025","journal-title":"Inflammation"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13349","article-title":"Novel lncRNA-prader willi\/angelman region RNA, SNRPN neighbour (PWARSN) aggravates tubular epithelial cell pyroptosis by regulating TXNIP via dual way in diabetic kidney disease","volume":"56","author":"Song","year":"2023","journal-title":"Cell Prolif"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-023-04501-1","article-title":"Circular RNA COL1A2 mediates high glucose-induced oxidative stress and pyroptosis by regulating miR-424-5p\/SGK1 in diabetic nephropathy","volume":"195","author":"Zhuang","year":"2023","journal-title":"Appl Biochem Biotechnol"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.828240","article-title":"Circ_0004951 promotes pyroptosis of renal tubular cells via the NLRP3 inflammasome in diabetic kidney disease","volume":"9","author":"Wang","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123760","article-title":"The axis of miR-30a\/AIF-1\/TRPC6\/calcineurin A\/NFAT2 regulated the death modalities and inflammation of renal tubular epithelial cells in diabetic kidney disease via exosome","volume":"377","author":"Hao","year":"2025","journal-title":"Life Sci"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.81892","article-title":"Emerging role of ferroptosis in diabetic kidney disease: molecular mechanisms and therapeutic opportunities","volume":"19","author":"Wang","year":"2023","journal-title":"Int J Biol Sci"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"key":"B189","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol Cell"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2025.2576881","article-title":"High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell","volume":"58","author":"Qin","year":"2025","journal-title":"Autoimmunity"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-025-00706-5","article-title":"Overexpression of GPX4 in diabetic rat kidney alleviates renal injury induced by ferroptosis","volume":"38","author":"Wu","year":"2025","journal-title":"Biometals"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112303","article-title":"Hederagenin improves renal fibrosis in diabetic nephropathy by regulating Smad3\/NOX4\/SLC7A11 signaling-mediated tubular cell ferroptosis","volume":"135","author":"Jia","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2025.2529618","article-title":"ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1\/Nrf2 signaling","volume":"30","author":"Liu","year":"2025","journal-title":"Redox Rep"},{"key":"B196","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12964-023-01170-9","article-title":"The emerging roles of MAPK-AMPK in ferroptosis regulatory network","volume":"21","author":"Wang","year":"2023","journal-title":"Cell Commun Signal"},{"key":"B197","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s13020-024-01007-8","article-title":"Suppression of ferroptosis through the SLC7A11\/glutathione\/glutathione peroxidase 4 axis contributes to the therapeutic action of the Tangshenning formula on diabetic renal tubular injury","volume":"19","author":"Shan","year":"2024","journal-title":"Chin Med"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167060","article-title":"GLP-1 receptor agonist attenuates tubular cell ferroptosis in diabetes via enhancing AMPK-fatty acid metabolism pathway through macropinocytosis","volume":"1870","author":"Shen","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2019.151058","article-title":"Mitochondria regulation in ferroptosis","volume":"99","author":"Wang","year":"2020","journal-title":"Eur J Cell Biol"},{"key":"B200","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s10020-025-01318-y","article-title":"Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy","volume":"31","author":"Lu","year":"2025","journal-title":"Mol Med"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.2337\/db25-0282","article-title":"Trem2+ macrophages alleviate renal tubule lipid accumulation and ferroptosis in diabetic nephropathy by repressing IL-1beta-mediated CD36 expression","volume":"74","author":"Wang","year":"2025","journal-title":"Diabetes"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2022.2067572","article-title":"Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis","volume":"60","author":"Huang","year":"2022","journal-title":"Pharm Biol"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118517","article-title":"Proteomic and lipidomic analysis of the mechanism underlying astragaloside IV in mitigating ferroptosis through hypoxia-inducible factor 1alpha\/heme oxygenase 1 pathway in renal tubular epithelial cells in diabetic kidney disease","volume":"334","author":"Liu","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.70044","article-title":"Naringenin inhibits ferroptosis in renal tubular epithelial cells of diabetic nephropathy through SIRT1\/FOXO3a signaling pathway","volume":"86","author":"Zhou","year":"2025","journal-title":"Drug Dev Res"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2024.2438857","article-title":"Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through beta-hydroxybutyrate production","volume":"47","author":"Tian","year":"2025","journal-title":"Ren Fail"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.177140","article-title":"Empagliflozin attenuates renal tubular ferroptosis in preeclampsia via tazarotene-induced gene 1","volume":"986","author":"Tong","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202505168","article-title":"Adaptive antioxidant nanomedicines inhibit ferroptosis in renal tubular epithelial cells to alleviate diabetic kidney disease","volume":"12","author":"Liu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B208","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.molmed.2023.10.001","article-title":"Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes","volume":"30","author":"Pandeya","year":"2024","journal-title":"Trends Mol Med"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1759781","article-title":"Identification of PANoptosis hub genes driving immune activation and tubulointerstitial injury in diabetic kidney disease by integrative bioinformatics and machine learning","volume":"17","author":"Chen","year":"2026","journal-title":"Front Immunol"},{"key":"B210","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1159\/000546764","article-title":"Construction of a PANoptosis-related gene signature for diabetic nephropathy","volume":"50","author":"Geng","year":"2025","journal-title":"Kidney Blood Press Res"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1659065","article-title":"Integrated bioinformatics and machine learning reveal pan-apoptosis and immune infiltration signatures in diabetic nephropathy","volume":"16","author":"Liu","year":"2025","journal-title":"Front Immunol"},{"key":"B212","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s10753-025-02400-7","article-title":"Integrated transcriptomic analysis identifies TAP1 as a key regulator of PANoptosis in diabetic kidney disease tubular injury","volume":"49","author":"Chen","year":"2026","journal-title":"Inflammation"},{"key":"B213","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s12031-025-02384-x","article-title":"Finerenone modulates PANoptosis to improve immune microenvironment in diabetic nephropathy: a machine learning-based mechanistic analysis","volume":"75","author":"Chen","year":"2025","journal-title":"J Mol Neurosci"},{"key":"B214","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2024.2431142","article-title":"Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases","volume":"47","author":"Ren","year":"2025","journal-title":"Ren Fail"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-025-04798-5","article-title":"Integrated multi-omics and experimental validation reveal FDX1\/LIAS-mediated cuproptosis as a potential driver of diabetic kidney disease","volume":"204","author":"Liu","year":"2026","journal-title":"Biol Trace Elem Res"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.20346","article-title":"The cuproptosis-related gene ITGB6 and LTBP1 may be associated with diabetic kidney disease progression and immune cell infiltration","volume":"13","author":"Hu","year":"2025","journal-title":"PeerJ"},{"key":"B218","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev-cellbio-020520-111016","article-title":"Cellular mechanisms of NETosis","volume":"36","author":"Thiam","year":"2020","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B219","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1186\/s40001-026-04041-4","article-title":"Neutrophil activation, NETs formation, and inflammation in diabetic kidney disease: therapeutic perspectives","volume":"31","author":"Deng","year":"2026","journal-title":"Eur J Med Res"},{"key":"B220","doi-asserted-by":"publisher","first-page":"693","DOI":"10.21037\/atm-22-2382","article-title":"Midkine promotes kidney injury in diabetic kidney disease by increasing neutrophil extracellular traps formation","volume":"10","author":"Liu","year":"2022","journal-title":"Ann Transl Med"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/4815488","article-title":"NET-related gene as potential diagnostic biomarkers for diabetic tubulointerstitial injury","volume":"2024","author":"Liang","year":"2024","journal-title":"J Diabetes Res"},{"key":"B222","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s00018-021-04109-w","article-title":"The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis","volume":"79","author":"Liu","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"B223","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s11033-025-10997-z","article-title":"Lysosome-dependent cell death: disease implications and potential therapeutic targets","volume":"52","author":"Gemingnuer","year":"2025","journal-title":"Mol Biol Rep"},{"key":"B224","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s10020-024-01020-5","article-title":"Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy","volume":"30","author":"Liu","year":"2024","journal-title":"Mol Med"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-026-02267-5","article-title":"SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease","volume":"31","author":"Jian","year":"2026","journal-title":"Apoptosis"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157164","article-title":"Schisandra chinensis mixture attenuates diabetic kidney disease via VDAC1\/Grp75\/IP(3)R-mediated MAMs stabilization and apoptosis-autophagy regulation","volume":"147","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2022.109347","article-title":"Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease","volume":"727","author":"Yuan","year":"2022","journal-title":"Arch Biochem Biophys"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15491","article-title":"High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205233","article-title":"Investigating EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy: an in silico and in vitro validation study","volume":"15","author":"Wang","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1271145","article-title":"Identification of necroptosis-related features in diabetic nephropathy and analysis of their immune microenvironent and inflammatory response","volume":"11","author":"Hu","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"B231","doi-asserted-by":"publisher","first-page":"22613","DOI":"10.1038\/s41598-022-26495-2","article-title":"Identification of ferroptosis-related genes and pathways in diabetic kidney disease using bioinformatics analysis","volume":"12","author":"Liu","year":"2022","journal-title":"Sci Rep"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1183530","article-title":"Identification of ferroptosis-related genes as potential diagnostic biomarkers for diabetic nephropathy based on bioinformatics","volume":"10","author":"Guo","year":"2023","journal-title":"Front Mol Biosci"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-024-04158-7","article-title":"Identification of hub genes associated with pyroptosis in diabetic nephropathy patients using integrated bioinformatic analysis","volume":"57","author":"Wang","year":"2025","journal-title":"Int Urol Nephrol"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177414","article-title":"Crosstalk between autophagy and other forms of programmed cell death","volume":"995","author":"Wang","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1877238\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:53:07Z","timestamp":1785487987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1877238\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":235,"alternative-id":["10.3389\/fendo.2026.1877238"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1877238","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"article-number":"1877238"}}