{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:35:45Z","timestamp":1782894945327,"version":"3.54.5"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and validate a risk prediction model for psychological distress in patients with differentiated thyroid cancer (DTC) undergoing \u00b9\u00b3\u00b9I therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 247 DTC patients who received \u00b9\u00b3\u00b9I therapy at a tertiary Grade A hospital in Taiyuan between May and December 2025 were enrolled. Independent risk factors for psychological distress were identified to construct the model. Model performance was evaluated using receiver operating characteristic (ROC) curves, the Hosmer-Lemeshow test, and calibration curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate logistic regression identified poor sleep quality, thyroid-stimulating hormone (TSH) stimulation, pulmonary metastasis, social support, radiation exposure concerns, and lower serum 25-hydroxyvitamin D levels as independent risk factors (all\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). The nomogram model achieved an area under the ROC curve (AUC) of 0.835, with a sensitivity of 83.1% and a specificity of 68.2%. The Hosmer-Lemeshow test yielded a \u03c7\u00b2 of 12.064 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.148). Calibration curves and decision curve analysis (DCA) confirmed good calibration and clinical utility. Internal validation via bootstrap resampling and 10-fold cross-validation produced AUCs of 0.82 and 0.77, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This internally validated model is a promising tool for predicting psychological distress in DTC patients undergoing \u00b9\u00b3\u00b9I therapy. However, external validation in larger, multicenter cohorts is necessary before routine clinical use can be recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1877295","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:48:36Z","timestamp":1782888516000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and validation of a prediction model for psychological distress in patients with differentiated thyroid cancer undergoing \u00b9\u00b3\u00b9I therapy"],"prefix":"10.3389","volume":"17","author":[{"given":"Lingling","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou","place":["Chongqing, China"]},{"name":"College of Nursing, Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Nursing, Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, First Hospital of Shanxi Medical University","place":["Taiyuan, Shanxi, China"]},{"name":"Collaborative Innovation Center for Molecular Imaging of Precision Medicine","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.19538\/j.cjps.issn1005-2208.2022.12.02","article-title":"Guidelines for the diagnosis and treatment of thyroid carcinoma (2022 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