{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:12:12Z","timestamp":1788783132740,"version":"build-2803163510"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the safety and efficacy of Ultrasound-guided radiofrequency ablation (US-guided RFA) compared to laparoscopic adrenalectomy (LA) for the treatment of aldosterone-producing adenoma (APA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, two-center study evaluated 100 patients with APA treated with either US-guided RFA or LA between January 2020 and June 2024. Patients were categorized based on treatment modality (US-guided RFA: n=36; LA: n=64). To minimize confounding, a 1:1 matching was performed based on sex, age, medical history, and disease characteristics. Post-treatment outcomes, including biochemical remission and blood pressure control, were compared using independent-samples t-tests or chi-square tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 36 patients (median age: 49.5 years [IQR: 33.25\u201357.00]; 23 women) underwent US-guided RFA, and 36 matched patients (median age: 52.00 years [IQR: 37.50\u201359.75]; 20 women) underwent LA. The technical success rate was 100% in both groups. During the follow-up period (median: 14 months [IQR: 6\u201322 months]), both groups achieved complete biochemical remission (36\/36,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a01.000), similar hypertension control rates (66.7% vs. 77.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.430), and no disease progression (0\/36 in both groups). US-guided RFA was associated with significantly lower intraoperative blood loss (median: 3.0 mL vs. 30 mL) and shorter procedure time (77.5\u00a0min vs. 115\u00a0min; both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with unilateral isolated APA, no significant differences were observed between US-guided RFA and LA in terms of disease progression, biochemical remission, or hypertension control in the short term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1880658","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:37:31Z","timestamp":1788781051000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound-guided radiofrequency ablation versus laparoscopic adrenalectomy for unilateral isolated aldosterone-producing adenoma: a two-center retrospective study"],"prefix":"10.3389","volume":"17","author":[{"given":"Lingpeng","family":"Tang","sequence":"first","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Ultrasonography, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingzi","family":"Zou","sequence":"additional","affiliation":[{"name":"Shengli Clinical 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