{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:07:49Z","timestamp":1784092069542,"version":"3.55.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The aim of this retrospective study was to investigate the differences in early- and delayed-phase maximum standardized uptake value (SUVmax) and lesion volume on\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-sestamibi (99mTc-MIBI) SPECT\/CT between parathyroid adenoma (PA) and parathyroid hyperplasia (PH) in patients with secondary hyperparathyroidism (SHPT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      A total of 111 patients with stage 5 chronic kidney disease (CKD5) undergoing hemodialysis were enrolled in this study. All patients underwent preoperative\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MIBI SPECT\/CT scintigraphy for the detection and localization of parathyroid lesions. Quantitative SPECT\/CT was performed after planar imaging, and the SUVmax and volume of each positive parathyroid lesions were measured on SPECT\/CT. Linear mixed-effects models accounting for within-patient clustering were used to compare parameters between PA and PH, with further adjustment for lesion volume. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminative ability of these parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjustment for within-patient clustering, PA lesions showed significantly higher early-phase SUVmax (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 1.473,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001), delayed-phase SUVmax (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.745,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001), and lesion volume (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.571,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001) than PH lesions. After further adjustment for lesion volume, the difference in early-phase SUVmax remained significant (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.542,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.034), whereas the difference in delayed-phase SUVmax was no longer significant (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.404). Lesion volume was strongly associated with both early- and delayed-phase SUVmax (both\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). A ROC curve analysis showed that the area under the curve (AUC) for early-phase SUVmax and lesion volume was 0.612 and 0.621, respectively, for distinguishing PA from PH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Lesion volume is a major determinant of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MIBI uptake in SHPT, while early-phase SUVmax remains independently different after adjustment for volume. When combined with clinical presentation and other examinations, early-phase SUVmax may provide complementary biological information for graft selection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1883661","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:44:31Z","timestamp":1784090671000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in quantitative 99mTc-MIBI SPECT\/CT parameters between parathyroid adenoma and hyperplasia in secondary hyperparathyroidism"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuhua","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital","place":["Taiyuan, 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000002510","article-title":"Asian consensus statement of experts on thermal ablation for secondary hyperparathyroidism in chronic kidney 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