{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:40Z","timestamp":1787721700437,"version":"build-2784847793"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The continuous evaluation of GFR among youth with T1D has traditionally been difficult during the transition to adult care given distinct pediatric &amp;amp; adult estimated GFR (eGFR) formulas recommended by clinical practice guidelines. We aimed to assess longitudinal trends in kidney function in type 1 diabetes from adolescence to early adulthood using updated eGFR formulae and to examine associations between eGFR and clinical as well as social factors over time in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical factors including age, sex, diabetes duration, insulin therapy, BMI and HbA1c in addition to social factors including ethnicity &amp;amp; material deprivation (MD) were collected alongside creatinine (Cr) and cystatin c (CysC) from Canadian participants in the AdDIT &amp;amp; CanSOLVE CKD-SPOR studies (2009-2023). Estimated glomerular filtration rates (eGFR) derived using updated Chronic Kidney Disease in Children under 25 (CKiD U25) Cr, CysC &amp;amp; combined Cr-CysC formulas were evaluated longitudinally using linear mixed effects regression, as were urine albumin-creatinine ratios (uACR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Youth with type 1 diabetes ages 10 to &amp;lt;25 years were evaluated (N\u00a0=\u00a0137) at a median 5 timepoints (IQR: 4-6) over 9.8 \u00b1 1.3 years. As age increased, eGFR\n                      <jats:sub>Cr<\/jats:sub>\n                      increased mildly (\u03b2:+1.0 ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      \/year; P&amp;lt;0.0001), whereas eGFR\n                      <jats:sub>CysC<\/jats:sub>\n                      decreased until the age of 18 (\u03b2:-3.3 ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      \/year; P&amp;lt;0.0001) and stabilized thereafter (\u03b2: +0.1 ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      \/year; P\u00a0=\u00a00.433). These trends nullified one another across the age range using the combined eGFR\n                      <jats:sub>Cr-CysC<\/jats:sub>\n                      , which remained stable (\u03b2:-0.1 ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      \/year) from ages 10\u201325 years (P\u00a0=\u00a00.452). Sex, BMI, insulin therapy, HbA1c and MD were associated with eGFR\n                      <jats:sub>Cr-CysC<\/jats:sub>\n                      over time with a large difference of +6.5 ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      seen in high relative to low MD groups (P\u00a0=\u00a00.0025). Log-transformed uACR was negatively associated with male sex (P\u00a0=\u00a00.017) and baseline diabetes duration (P\u00a0=\u00a00.049) yet positively associated with HbA1c (P\u00a0=\u00a00.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Different eGFR trends were observed using Cr- vs. CysC-derived estimates in youth with diabetes using updated eGFR formulae. Elevations in eGFR, alongside alterations in markers of albuminuria, were associated with increased glycemia and marginalization, providing insights into key clinical and social risk factors for kidney disease monitoring in this population. (NCT01581476).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1888628","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:50:21Z","timestamp":1787719821000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal evaluation of glomerular filtration rate across adolescence and early adulthood in youth with type 1 diabetes: associations with clinical and social risk factors"],"prefix":"10.3389","volume":"17","author":[{"given":"Antoine B. 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Neil","family":"Dalton","sequence":"additional","affiliation":[{"name":"Evelina London Children\u2019s Hospital, Guy\u2019s and St Thomas\u2019 National Health Service Foundation Trust","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Perth Children\u2019s Hospital","place":["Nedlands, WA, Australia"]},{"name":"Paediatrics Division, University of Western Australia","place":["Crawley, WA, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally M.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Translational and Clinical Research Institute, Faculty of Clinical Medical Sciences, Newcastle University","place":["Newcastle upon Tyne, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Z. 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Loredana","family":"Marcovecchio","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Cambridge","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid H.","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children","place":["Toronto, ON, Canada"]},{"name":"Institute of Medical Science, University of Toronto","place":["Toronto, ON, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13444","article-title":"Ispad clinical practice consensus guidelines 2022: Microvascular and macrovascular complications in children and adolescents with diabetes","volume":"23","author":"Bjornstad","year":"2022","journal-title":"Pediatr Diabetes"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S014","article-title":"14. 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