{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:05:06Z","timestamp":1790057106428,"version":"4.0.1"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exercise-responsive endocrine-metabolic mediators may contribute to the systemic cardiometabolic adaptations induced by physical activity, but the literature spans diverse mediator classes, exercise paradigms, disease contexts, and experimental models. We conducted a systematic scoping review and evidence map to characterize the structure of this evidence and the biological relations examined across the field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed\/MEDLINE, Web of Science Core Collection, and Scopus were searched from database inception through 7 August 2026. Titles and abstracts, followed by full texts, were independently assessed by two reviewers, with third-reviewer adjudication where required. Eligible primary reports underwent a separate round of independent full-text data charting using a relational framework linking reports, exercise contrasts, and mediator evidence. Cardiometabolic contexts and outcome domains were coded using multi-label rules, synonymous mediator terminology was harmonized, and companion publications were linked before study-level synthesis. Six potentially co-occurring evidence relations were mapped: exercise responsiveness, cardiometabolic association, source\/secretion evidence, receptor\/pathway evidence, functional perturbation, and formal mediation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The searches yielded 3,388 records, of which 1,535 unique records underwent title\/abstract screening and 397 reports underwent full-text assessment. The final primary evidence map comprised 365 reports representing 363 underlying studies, 413 exercise contrasts, 776 mediator-evidence observations, and 103 harmonized named mediators. Obesity\/overweight was represented in 78.0% of studies. Among the 308 studies contributing named mediators, adipokines were represented in 58.4%, cytokines\/chemokines in 32.1%, and myokines in 25.6%. Adiponectin, leptin, IL-6, and irisin were the most frequently represented named mediators. Exercise-responsive evidence and cardiometabolic associations were identified in 90.9% and 87.0% of contributing studies, respectively, whereas source\/secretion evidence (18.5%), receptor\/pathway evidence (9.7%), functional perturbation (11.4%), and formal mediation (0.3%) were less frequently represented. Chronic training accounted for 81.6% of exercise contrasts and aerobic\/endurance exercise for 63.4%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exercise-responsive mediator research in cardiometabolic disease comprises a concentrated group of recurrent adipokines, cytokines, and myokines alongside a broad, sparsely studied mediator landscape. Exercise-responsive evidence and cardiometabolic associations were frequently represented, whereas direct investigation of tissue source, downstream pathways, functional perturbation, and formal mediation was less common. Studies integrating well-characterized exercise exposures with serial mediator assessment, source validation, and mechanistic testing may help define how exercise-responsive signaling contributes to cardiometabolic adaptation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1892959","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:38:52Z","timestamp":1790055532000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise-responsive endocrine-metabolic mediators in diabetes and cardiometabolic disorders: a systematic scoping review and evidence map"],"prefix":"10.3389","volume":"17","author":[{"given":"Zihang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University","place":["Shijiazhuang, China"]},{"name":"Hebei Medical University","place":["Shijiazhuang, 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