{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:27:44Z","timestamp":1786116464853,"version":"build-2736575974"},"reference-count":187,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Craniopharyngiomas are low-grade, intracranial tumors frequently associated with dysfunction of the hypothalamic\u2013pituitary axes and the development of obesity. This narrative review aimed to evaluate the potential contribution of eating behaviors, while also identifying perspectives for future therapeutic intervention. Searches were performed across five bibliographic databases. All peer-reviewed published studies involving childhood-onset or adult-onset craniopharyngioma populations were considered eligible when they examined eating behavior in relation to pharmacological or surgical interventions, neuroimaging, endocrine responses, energy expenditure, sleep, and\/or neuropsychological outcomes. The available evidence regarding eating behavior in individuals with craniopharyngioma was limited, with only 10 of the 82 included studies employing validated measures of eating behavior. Eating behavior was assessed as a primary outcome in seven studies, as a secondary outcome in twelve studies, and discussed without formal measurement in thirty-one studies. Only one randomized controlled trial with the melanocortin-4 receptor (MC4R) agonist setmelanotide was identified that successfully targeted eating behavior (hyperphagia) modification and achieved significant weight loss as an intervention for craniopharyngioma-related obesity. Greater insight into eating behavior in this population, supported by long-term studies using validated assessment tools, is required to clarify the mechanisms underlying craniopharyngioma-associated obesity and confirm effectiveness and tolerability of medical treatment with MC4R-agonists.<\/jats:p>","DOI":"10.3389\/fendo.2026.1895026","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T10:24:26Z","timestamp":1786011866000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hunger, satiety, and eating behavior after craniopharyngioma \u2013 narrative review on current management and future therapeutic perspectives"],"prefix":"10.3389","volume":"17","author":[{"given":"Hermann L.","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology, University Children\u2019s Hospital, Carl von Ossietzky Universit\u00e4t, Klinikum Oldenburg A\u00f6R","place":["Oldenburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1530\/ey.16.11.14","article-title":"Pathophysiology and individualized treatment of hypothalamic obesity following craniopharyngioma and other suprasellar tumors: a systematic review","volume":"40","author":"van Iersel","year":"2019","journal-title":"Endocr Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1530\/endoabs.35.s4.1","article-title":"Craniopharyngioma","volume":"5","author":"Muller","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"B3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s11102-025-01602-4","article-title":"Craniopharyngioma \u2013 what\u2019s next","volume":"28","author":"M\u00fcller","year":"2025","journal-title":"Pituitary"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac035","article-title":"Contemporary biological insights and clinical management of craniopharyngioma","volume":"44","author":"Apps","year":"2023","journal-title":"Endocr Rev"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3171\/foc.1997.3.6.4","article-title":"The descriptive epidemiology of craniopharyngioma","volume":"89","author":"Bunin","year":"1998","journal-title":"J Neurosurg"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13439","article-title":"Hypothalamic obesity: epidemiology in rare sellar\/suprasellar tumors-a German claims database analysis","volume":"36","author":"Witte","year":"2024","journal-title":"J Neuroendocrinol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1093\/neuonc\/nos218","article-title":"CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009","author":"Dolecek","year":"2012","journal-title":"Neuro-Oncology"},{"key":"B8","article-title":"Adamantinomatous craniopharyngioma","volume-title":"WHO Classification of Tumours Editorial Board Central Nervous System Tumours. 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