{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:24:26Z","timestamp":1787217866973,"version":"build-2736575974"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This multicentre retrospective cohort study examined whether maternal serum uric acid measured before 24 weeks of gestation was associated with subsequent gestational diabetes mellitus (GDM), with hypertensive disorders of pregnancy (HDP) assessed as a related cardiometabolic outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 5,614 pregnancies from three hospitals in China. For each pregnancy, the earliest eligible uric acid measurement before 24 weeks of gestation was retained. Uric acid was analysed in quartiles and per 10 \u03bcmol\/L increase. Modified Poisson regression with robust variance estimated relative risks (RRs), restricted cubic splines assessed dose-response patterns, and sensitivity analyses examined the stability of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GDM occurred in 1,187 pregnancies (21.1%) and HDP in 275 pregnancies (4.9%). Compared with Q1, Q4 was associated with higher risk of GDM (adjusted RR, 1.54; 95% CI, 1.34 to 1.77) and HDP (adjusted RR, 1.89; 95% CI, 1.33 to 2.67). Each 10 \u03bcmol\/L increase in uric acid was associated with GDM (adjusted RR, 1.03; 95% CI, 1.02 to 1.04) and HDP (adjusted RR, 1.04; 95% CI, 1.02 to 1.06). Spline analyses showed modest evidence of nonlinearity for GDM but not for HDP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Maternal serum uric acid measured before 24 weeks of gestation was associated with subsequent GDM, with a related association observed for HDP. Uric acid may complement established maternal risk factors but should not be interpreted as a standalone screening test.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1896745","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:05:48Z","timestamp":1784905548000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal serum uric acid before 24 weeks of gestation and subsequent gestational diabetes mellitus: a multicentre retrospective cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Qinquan","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The People\u2019s Hospital of Lincang","place":["Lincang, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saijie","family":"Ma","sequence":"additional","affiliation":[{"name":"Kidney and Metabolism Center, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gong\u2019an County Hospital","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Wu","sequence":"additional","affiliation":[{"name":"Kidney and Metabolism Center, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, The People\u2019s Hospital of Lincang","place":["Lincang, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Information Management, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine","place":["Shanghai, China, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00734-y","article-title":"A global view of hypertensive disorders and diabetes mellitus during pregnancy","volume":"18","author":"Jiang","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00825-0","article-title":"Epidemiology and management of gestational diabetes","volume":"404","author":"Sweeting","year":"2024","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00827-4","article-title":"Pathophysiology from preconception, during pregnancy, and beyond","volume":"404","author":"Hivert","year":"2024","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848","article-title":"International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","year":"2010","journal-title":"Diabetes Care"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.12.009","article-title":"Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: report of a scientific workshop organized by the National Kidney Foundation","volume":"71","author":"Johnson","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.10.007","article-title":"Hyperuricemia and endothelial function: from molecular background to clinical perspectives","volume":"278","author":"Maruhashi","year":"2018","journal-title":"Atherosclerosis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12958-021-00748-7","article-title":"Uric acid participating in female reproductive disorders: a review","volume":"19","author":"Hu","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.14022","article-title":"Maternal uric acid levels and risk of gestational diabetes mellitus: a systematic review and dose-response meta-analysis of cohort studies including 105,380 participants","volume":"14","author":"Nikparast","year":"2023","journal-title":"J Diabetes Investig"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2023.2231101","article-title":"Serum uric acid and the risk of gestational diabetes mellitus: a systematic review and meta-analysis","volume":"39","author":"Su","year":"2023","journal-title":"Gynecol Endocrinol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2021.101293","article-title":"Serum uric acid in early pregnancy and risk of gestational diabetes mellitus: a cohort study of 85,609 pregnant women","volume":"48","author":"Zhao","year":"2022","journal-title":"Diabetes Metab"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60731-5","article-title":"Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis","volume":"373","author":"Bellamy","year":"2009","journal-title":"Lancet"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.116.003497","article-title":"Preeclampsia and future cardiovascular health: a systematic review and meta-analysis","volume":"10","author":"Wu","year":"2017","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational hypertension and preeclampsia: ACOG Practice Bulletin, Number 222","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090","article-title":"A modified Poisson regression approach to prospective studies with binary data","volume":"159","author":"Zou","year":"2004","journal-title":"Am J Epidemiol"},{"key":"B16","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-19425-7","volume-title":"Regression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis","author":"Harrell","year":"2015"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu207","article-title":"Towards better clinical prediction models: seven steps for development and an ABCD for validation","volume":"35","author":"Steyerberg","year":"2014","journal-title":"Eur Heart J"},{"key":"B18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.7326\/M14-0697","article-title":"Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis: TRIPOD statement","volume":"162","author":"Moons","year":"2015","journal-title":"Ann Intern Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116811","article-title":"PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to \u03b2 cell function and metabolic disease","volume":"45","author":"Fan","year":"2026","journal-title":"Cell Rep"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2022.151240","article-title":"Amino acids control blood glucose levels through mTOR signaling","volume":"101","author":"Fan","year":"2022","journal-title":"Eur J Cell Biol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2026.1771707","article-title":"Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species","volume":"17","author":"Fan","year":"2026","journal-title":"Front Genet"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2026.1765602","article-title":"Metabolic biomarkers in early detection of gestational diabetes mellitus: a prospective diagnostic accuracy study","volume":"13","author":"Tigli","year":"2026","journal-title":"Front Med (Lausanne)"}],"updated-by":[{"DOI":"10.3389\/fendo.2026.1950401","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000}}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1896745\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:34:30Z","timestamp":1787214870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1896745\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":22,"alternative-id":["10.3389\/fendo.2026.1896745"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1896745","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"article-number":"1896745"}}