{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:03:12Z","timestamp":1782975792358,"version":"3.54.5"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In obstructive sleep apnea (OSA), respiratory events differ not only in frequency but also in the depth and duration of oxygen desaturation. The triglyceride-glucose (TyG) index is a routinely available marker related to insulin resistance, but its relationship with conventional nocturnal oxygenation-related parameters in OSA remains incompletely clarified. Objective: We examined the association of the TyG index with hypoxemia-related sleep parameters and explored whether these associations were influenced by monitoring modality and AHI-defined OSA severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single-center retrospective cross-sectional study screened 154 consecutive symptomatic adult inpatients from 2021 to 2025; after exclusion of 11 patients, 143 were included in the retrospective dataset. Diagnostic sleep monitoring was performed using in-laboratory polysomnography or Nox T3 portable monitoring. Laboratory measurements were obtained within 3 days before or after sleep monitoring. Severe nocturnal oxygen desaturation was defined as lowest SpO\n                      <jats:sub>2<\/jats:sub>\n                      &amp;lt;80%, and severe AHI-defined OSA was defined as AHI \u226530 events\/h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TyG was available in 116 patients, and 101 had complete TyG, lowest SpO\n                      <jats:sub>2<\/jats:sub>\n                      , and AHI data. TyG was higher in patients with lowest SpO\n                      <jats:sub>2<\/jats:sub>\n                      &amp;lt;80% than in those with lowest SpO\n                      <jats:sub>2<\/jats:sub>\n                      \u226580% [9.252 (8.872, 9.577) vs. 8.780 (8.574, 8.963), P&amp;lt;0.001], and higher in patients with AHI \u226530 events\/h than in those with AHI &amp;lt;30 events\/h [9.242 (8.869, 9.624) vs. 8.823 (8.571, 9.121), P&amp;lt;0.001]. TyG correlated positively with AHI and CT90 and negatively with mean and lowest SpO\n                      <jats:sub>2<\/jats:sub>\n                      . The AUC was 0.760 for lowest SpO\n                      <jats:sub>2<\/jats:sub>\n                      &amp;lt;80% and 0.715 for AHI \u226530 events\/h. In models adjusted for age, sex, BMI, and monitoring modality, TyG remained associated with lowest SpO\n                      <jats:sub>2<\/jats:sub>\n                      &amp;lt;80% and AHI \u226530 events\/h. However, the association with lowest SpO\n                      <jats:sub>2<\/jats:sub>\n                      &amp;lt;80% was attenuated after additional adjustment for AHI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher TyG was associated with worse nocturnal oxygenation-related parameters and greater AHI-defined OSA severity, but these exploratory findings may partly reflect overall OSA severity. TyG may provide a simple metabolic clue for risk stratification, but it cannot replace formal sleep monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1899452","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:36:08Z","timestamp":1782970568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Triglyceride-glucose index and nocturnal oxygenation impairment in patients with obstructive sleep apnea"],"prefix":"10.3389","volume":"17","author":[{"given":"Chong","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Anhui Medical University (Hefei First People\u2019s Hospital)","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Anhui Medical University (Hefei First People\u2019s Hospital)","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Third Affiliated Hospital of Anhui Medical University (Hefei First People\u2019s Hospital)","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Anhui Medical University (Hefei First People\u2019s Hospital)","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Anhui Medical University (Hefei First People\u2019s Hospital)","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (Anhui Provincial Hospital)","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine clinical practice guideline","volume":"13","author":"Kapur","year":"2017","journal-title":"J Clin Sleep 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