{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:25:31Z","timestamp":1787117131727,"version":"build-2736575974"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the cross-sectional associations of the triglyceride\u2013glucose (TyG) index and the metabolic score for insulin resistance (METS-IR) with brachial\u2013ankle pulse wave velocity (baPWV) in women and to examine whether these associations differed by menopausal status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional secondary analysis included 306 women (134 premenopausal and 172 postmenopausal). baPWV was analyzed as a continuous measure of arterial stiffness. Associations with TyG and METS-IR were examined using Pearson correlation, restricted cubic splines, and multivariable linear regression; the primary adjusted model included age, menopausal status, systolic blood pressure, uric acid, LDL-C, and eGFR and omitted BMI because BMI is a component of METS-IR. Exploratory ROC analyses compared the discrimination of covariate-adjusted TyG and METS-IR models for elevated baPWV (\u22651400 cm\/s) using the DeLong test. Sensitivity and menopausal-status subgroup analyses were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both METS-IR and TyG were positively correlated with baPWV in unadjusted analyses. After adjustment for menopausal status, age, SBP, uric acid, LDL-C, and eGFR, METS-IR remained associated with baPWV (\u03b2 = 4.72, 95% CI 1.03\u20138.41, P\u00a0=\u00a00.012), whereas TyG did not (\u03b2 = 26.66, 95% CI \u221211.49\u201364.81, P\u00a0=\u00a00.170). In stratified analyses, METS-IR was associated with baPWV in postmenopausal women (\u03b2 = 5.68, 95% CI 0.74\u201310.61, P\u00a0=\u00a00.025) but not in premenopausal women (\u03b2 = 4.16, 95% CI \u22121.22\u20139.53, P\u00a0=\u00a00.128); however, the interaction was not significant (P for interaction = 0.722). The TyG and METS-IR models showed similar exploratory discrimination for elevated arterial stiffness (AUC 0.831\n                      <jats:italic>vs<\/jats:italic>\n                      0.834; DeLong P\u00a0=\u00a00.331).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cross-sectional dataset of women, METS-IR retained an adjusted association with baPWV, whereas the corresponding association for TyG was not statistically significant. Menopausal status did not significantly modify either association. The TyG and METS-IR models showed similar exploratory discrimination for elevated baPWV. Prospective external studies are needed to assess temporal associations and clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1902406","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:41:39Z","timestamp":1787114499000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative associations of the TyG index and METS-IR with arterial stiffness in women: a cross-sectional analysis by menopausal status"],"prefix":"10.3389","volume":"17","author":[{"given":"Like","family":"Yang","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Peripheral Vascular Surgery, Guang\u2019anmen Hospital Jinan Hospital, China Academy of Chinese Medical Sciences (Jinan Municipal Hospital of Traditional Chinese Medicine)","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofei","family":"Han","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kundi","family":"Lv","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The First Affiliated Hospital of Shandong First Medical University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuiquan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Peripheral Vascular Surgery, Guang\u2019anmen Hospital Jinan Hospital, China Academy of Chinese Medical Sciences (Jinan Municipal Hospital of Traditional Chinese Medicine)","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of General Affairs, Jinan Center for Disease Control and Prevention","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat Rev Dis 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