{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:27:49Z","timestamp":1786429669718,"version":"build-2736575974"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    The proposed renaming of polycystic ovary syndrome (PCOS) as polyendocrine metabolic ovarian syndrome (PMOS) is an important step toward recognizing the systemic endocrine-metabolic nature of a condition historically misrepresented by ovarian cystic morphology. However, the persistence of the word ovarian remains conceptually limiting and reinforces the perception of a female-exclusive disorder. Published reports have provocatively proposed a male PCOS equivalent, particularly in male relatives of women with PCOS. We posit that those observations may be better conceptualized as male Endocrine-Metabolic Syndrome (male EMS), rather than male PCOS, hoping to offer a more coherent depiction of this clinical condition. In this perspective,\n                    <jats:italic>male EMS<\/jats:italic>\n                    is thus proposed as a sex-specific expression of shared endocrine-metabolic alteration characterized by insulin resistance, compensatory hyperinsulinemia, altered sex hormone-binding globulin dynamics, adrenal androgen dysregulation, early-onset androgenetic alopecia, acne or seborrhea, hypertrichosis, cardiometabolic vulnerability, and possible testicular or reproductive abnormalities. Unlike classical metabolic syndrome, male EMS would include endocrine-androgenic and dermatological features and may emerge earlier in life, particularly in individuals with a family history of female PCOS\/PMOS\/EMS. The present hypothesis remains to be validated prospectively, and male EMS should be considered a conceptual, research-oriented construct, not yet a defined clinical diagnosis. Nevertheless, such framework may help generate testable hypotheses and stimulate early identification of endocrine and cardiometabolic risk in men.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2026.1903408","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:35:17Z","timestamp":1786426517000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["From male PCOS to male endocrine-metabolic syndrome: a gender-neutral hypothesis"],"prefix":"10.3389","volume":"17","author":[{"given":"Maurizio","family":"Nordio","sequence":"first","affiliation":[{"name":"The Experts\u2019 Group On Inositol In Basic and Clinical Research, and on PMOS (EGOI-PCOS\/PMOS)","place":["Rome, Italy"]},{"name":"Department of Experimental Medicine, Sapienza University","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Barbaro","sequence":"additional","affiliation":[{"name":"The Experts\u2019 Group On Inositol In Basic and Clinical Research, and on PMOS (EGOI-PCOS\/PMOS)","place":["Rome, Italy"]},{"name":"U.O. Endocrinology, Livorno Hospital","place":["Livorno, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdemaro","family":"Pavacci","sequence":"additional","affiliation":[{"name":"UniCamillus \u2013 Saint Camillus International University of Health Sciences","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.18370\/2309-4117.2026.83.79-87","article-title":"Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process","volume":"407","author":"Teede","year":"2026","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12610-025-00290-1","article-title":"Male polycystic ovarian syndrome phenotype: a meta-analysis of endocrine-metabolic dysregulation in fathers and brothers of PCOS-affected women","volume":"35","author":"Jafarabady","year":"2025","journal-title":"Basic Clin Androl"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2025.2501694","article-title":"A different approach to PCOS: evaluation of spermiogram results in male patients with a family history of PCOS","volume":"41","author":"Ibanoglu","year":"2025","journal-title":"Gynecol Endocrinol"},{"key":"B4","article-title":"Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS)","volume":"62","author":"Lenarcik","year":"2011","journal-title":"Endokrynol Pol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s40618-017-0728-5","article-title":"Does a male polycystic ovarian syndrome equivalent exist","volume":"41","author":"Cannarella","year":"2018","journal-title":"J Endocrinol Invest"},{"key":"B6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.22074\/ijfs.2020.6092","article-title":"Male equivalent polycystic ovarian syndrome: hormonal, metabolic, and clinical aspects","volume":"14","author":"Di Guardo","year":"2020","journal-title":"Int J Fertil Steril"},{"key":"B7","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.tem.2023.08.005","article-title":"Questioning PCOS phenotypes for reclassification and tailored therapy","volume":"34","author":"Myers","year":"2023","journal-title":"Trends Endocrinol Metab"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076213","article-title":"A PCOS paradox: does inositol therapy find a rationale in all the different phenotypes","volume":"24","author":"Unfer","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-024-07571-6","article-title":"Has the name PCOS run its course","volume":"310","author":"Myers","year":"2024","journal-title":"Arch Gynecol Obstet"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-024-02512-1","article-title":"PCOS - 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