{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:00:24Z","timestamp":1785333624315,"version":"3.55.0"},"reference-count":118,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>As an interdisciplinary field investigating the skeletal and immune systems, bone immunology has revealed that these two systems share the bone marrow microenvironment, interacting with and regulating each other. Exercise, as a non-pharmacological intervention, has been demonstrated to provide a favorable environment for bone homeostasis by modulating the dynamic balance between osteogenesis and bone resorption. Furthermore, exercise enhances the body\u2019s anti-inflammatory capacity by regulating various immune components, including immune cells and cytokines, thereby optimizing overall immune function. This article systematically reviews how exercise may initiate a feed-forward osteoimmune circuit in which mechanical loading activates osteocytes and osteogenic progenitors, reshapes the bone marrow niche, promotes anti-inflammatory immune polarization, and subsequently favors bone formation over bone resorption Ultimately, this creates a virtuous cycle of bone immunology, offering novel therapeutic strategies for the prevention and treatment of bone metabolic diseases such as osteoporosis.<\/jats:p>","DOI":"10.3389\/fendo.2026.1904464","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:03:57Z","timestamp":1785330237000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise-induced osteoimmune crosstalk: a virtuous cycle between bone remodeling and immune regulation"],"prefix":"10.3389","volume":"17","author":[{"given":"Linlin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, The First Hospital of Jilin University","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiying","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, The First Hospital of Jilin University","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41413-025-00456-7","article-title":"Unraveling the mechanisms of bone diseases: targeting dendritic cells in osteoimmunology for internal homeostasis balance","volume":"13","author":"Chen","year":"2025","journal-title":"Bone 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