{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:12:40Z","timestamp":1788415960550,"version":"build-2803163510"},"reference-count":124,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    Uromodulin (Umod) is the most abundant urinary protein produced by the thick ascending limb (TAL) and distal convoluted tubule (DCT) of the kidney. Its physiological functions range from the protection against urinary tract infections (UTIs) and prevention of urinary stones to the modulation of ion transport along the distal nephron. Apart from the apical release into urine, Umod is delivered to the renal interstitium and serum via basolateral secretion to fulfil immunoregulatory tasks. Mutations and polymorphisms in the\n                    <jats:italic>Umod<\/jats:italic>\n                    gene have been associated with kidney and cardiovascular diseases, whereas serum and urinary Umod levels are emerging as biomarkers of renal and cardiovascular risks and conditions. Aging is associated with a gradual decline in both serum and urinary Umod levels, which may contribute to increased risk of UTI and kidney stones and decreased urinary concentration ability in older adults. The present review synthesizes the available information on endocrine regulation of Umod production and release during healthy and pathophysiological aging to specify translational perspectives of targeting the Umod biology and assist by interpretation of serum and urinary Umod levels as biomarkers of renal and cardiovascular health.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2026.1905594","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:15:15Z","timestamp":1788412515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endocrine regulation of uromodulin in aging"],"prefix":"10.3389","volume":"17","author":[{"given":"Kerim","family":"Mutig","sequence":"first","affiliation":[{"name":"Department of Biosciences, School of Medicine, Nazarbayev University","place":["Astana, Kazakhstan"]},{"name":"Sirius University of Science and Technology, Sirius Federal Territory","place":["Krasnodarsky krai, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prim B.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biosciences, School of Medicine, Nazarbayev University","place":["Astana, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Lebedeva","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.101","article-title":"Uromodulin: from physiology to rare and complex kidney disorders","volume":"13","author":"Devuyst","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"B2","first-page":"303","article-title":"Conclusione degli studi intorno all\u2019origine istologica dei cilindri dell\u2019urina","volume":"2","author":"Rovida","year":"1873"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-74-17825","article-title":"Characterization and separation of an inhibitor of viral hemagglutination present in urine","volume":"74","author":"Tamm","year":"1950","journal-title":"Proc Soc Exp Biol Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.2409603","article-title":"Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women","volume":"229","author":"Muchmore","year":"1985","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.3453112","article-title":"Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein","volume":"236","author":"Pennica","year":"1987","journal-title":"Science"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1159\/000063778","article-title":"The farsighted studies of the Italian Carlo L. 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