{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:08:07Z","timestamp":1789708087408,"version":"4.0.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to develop and validate a novel ultrasound radiomics model for predicting the attainment of near-adult height (NAH) in adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This dual-center prospective cohort study enrolled 192 adolescents aged 11.0\u201318.0 years. Standardized ultrasound examinations of the ulnar growth plate region were performed, and 475 radiomic features were extracted. Feature selection was conducted using Least Absolute Shrinkage and Selection Operator (LASSO) algorithm with 5-fold cross-validation. Seven machine learning algorithms were compared to develop predictive models. Three models were constructed: clinical (sex and bone age), radiomics (Rad-score), and combined (sex, bone age, and Rad-score). Model performance was evaluated using area under the receiver operating characteristic curve, accuracy, sensitivity, specificity, calibration curves, and decision curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three stable radiomic features were selected with selection frequency \u226580%: wavelet-LH_glcm_Imc2, wavelet-LL_ngtdm_Busyness, and wavelet-HL_firstorder_Energy. The combined model demonstrated superior performance, achieving AUCs of 0.981 (95% CI: 0.948\u20131.000) in the validation set, with sensitivity of 90% and specificity of 100%. Multivariate analysis identified independent positive predictors including Rad-score (OR\u00a0=\u00a03.28, P\u00a0=\u00a00.013) and bone age (OR\u00a0=\u00a02.65, P &amp;lt; 0.001). And male sex was a significant negative predictor (OR\u00a0=\u00a00.15, P\u00a0=\u00a00.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combined ultrasound radiomics machine learning model achieved excellent predictive performance for NAH attainment in adolescents. The non-ionizing ultrasound approach enables repeated dynamic monitoring, and the derived nomogram facilitates individualized risk stratification in routine pediatric practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1925196","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:36:06Z","timestamp":1789706166000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel method based on ultrasound radiomics for predicting attainment of near-adult height in adolescents"],"prefix":"10.3389","volume":"17","author":[{"given":"Yixuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]},{"name":"Zhangzhou Municipal Hospital Affiliated to Fujian Medical University","place":["Zhangzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2023.00346","article-title":"Growth plate closure and therapeutic interventions","volume":"67","author":"Cho","year":"2024","journal-title":"Clin Exp Pediatr"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.967711","article-title":"Factors affecting prepubertal and pubertal bone age progression","volume":"13","author":"Satoh","year":"2022","journal-title":"Front Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2025.1522060","article-title":"Prevalence and predictors of short stature in children aged 3-18 years in Hainan Province, China: a cross-sectional study","volume":"13","author":"Yan","year":"2025","journal-title":"Front Pediatr"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2025.1634605","article-title":"Prevalence of growth retardation among children and adolescents in China: a systematic review and meta-analysis","volume":"13","author":"Wang","year":"2025","journal-title":"Front Pediatr"},{"key":"B5","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12902-025-02084-y","article-title":"The incidence of early and precocious puberty of children in two Chinese cities: a multi-center prospective cohort study","volume":"25","author":"Chen","year":"2025","journal-title":"BMC Endocr Disord"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-023-03148-1","article-title":"Automated bone age assessment from knee joint by integrating deep learning and MRI-based radiomics","volume":"138","author":"Fan","year":"2023","journal-title":"Int J Legal Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2025.1615923","article-title":"Ultrasound-based bone age assessment in children and adolescents: a mini-review","volume":"13","author":"Zhang","year":"2025","journal-title":"Front Pediatr"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021204353","article-title":"Statistical confirmation of a method of US determination of bone age","volume":"300","author":"Wan","year":"2021","journal-title":"Radiology"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151169","article-title":"Radiomics: images are more than pictures, they are data","volume":"278","author":"Gillies","year":"2015","journal-title":"Radiology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/61\/13\/r150","article-title":"Applications and limitations of radiomics","volume":"61","author":"Yip","year":"2016","journal-title":"Phys Med Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-079969","article-title":"Bone age assessment based on three-dimensional ultrasound and artificial intelligence compared with paediatrician-read radiographic bone age: protocol for a prospective, diagnostic accuracy study","volume":"14","author":"Chen","year":"2024","journal-title":"BMJ Open"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2015-1","article-title":"Increased height standard deviation scores in response to growth hormone therapy to near-adult height in older children with delayed skeletal maturation: results from the ANSWER Program","volume":"2015","author":"Ross","year":"2015","journal-title":"Int J Pediatr Endocrinol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0509","article-title":"Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop","volume":"93","author":"Cohen","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"B14","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1046\/j.1365-2265.2002.01488.x","article-title":"Factors predicting adult height in girls with idiopathic central precocious puberty: implications for treatment","volume":"56","author":"Adan","year":"2002","journal-title":"Clin Endocrinol"},{"key":"B15","article-title":"Height and weight standardized growth charts for Chinese children and adolescents aged 0 to 18 years","volume":"47","author":"Li","year":"2009","journal-title":"Chin J Pediatr"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112140-20210525-00453","article-title":"Survey of height and weight of children and adolescents at different Tanner stages in urban China","volume":"59","author":"Pu","year":"2021","journal-title":"Chin J Pediatr"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15030257","article-title":"Bone age assessment using various medical imaging techniques enhanced by artificial intelligence","volume":"15","author":"Yuan","year":"2025","journal-title":"Diagnostics"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2025.02.004","article-title":"Use of the ultrasound bone maturity indexes to assess whether children have reached their final height","volume":"51","author":"Qiao","year":"2025","journal-title":"Ultrasound Med Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/children11080916","article-title":"Accurate prediction of children's target height from their mid-parental height","volume":"11","author":"Zeevi","year":"2024","journal-title":"Children (basel Switzerland)"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1177\/2192568220941450","article-title":"Prediction of final body height for female patients with adolescent idiopathic scoliosis","volume":"11","author":"Cheung","year":"2020","journal-title":"Global Spine J"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.16.01078","article-title":"Thumb ossification composite index (TOCI) for predicting peripubertal skeletal maturity and peak height velocity in idiopathic scoliosis: A validation study of premenarchal girls with adolescent idiopathic scoliosis followed longitudinally until skeletal maturity","volume":"99","author":"Hung","year":"2017","journal-title":"J Bone Joint Surg"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/bpo.0000000000003022","article-title":"Biomarker longitudinal idiopathic scoliosis study: predicting growth in idiopathic scoliosis","volume":"45","author":"Welborn","year":"2025","journal-title":"J Pediatr Orthopedics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1302\/2058-5241.5.190088","article-title":"The growth plate: a physiologic overview","volume":"5","author":"A\u011firdil","year":"2020","journal-title":"Off J Eur Fed Natl Associations Orthopaedics Traumatology Open Rev"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5718-2","article-title":"A systematic review of the agreement between chronological age and skeletal age based on the Greulich and Pyle atlas","volume":"29","author":"Dahlberg","year":"2018","journal-title":"Eur Radio"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1925196\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:36:11Z","timestamp":1789706171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1925196\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":24,"alternative-id":["10.3389\/fendo.2026.1925196"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1925196","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"article-number":"1925196"}}