{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:51:48Z","timestamp":1791377508767,"version":"4.3.2"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fertility preservation (FP) is a critical survivorship issue for young women with cancer, yet gaps persist between guidelines and clinical practice. This study assesses knowledge, attitudes, and unmet needs among women referred for specialist counseling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational cross-sectional survey was conducted (November 2022 \u2013 June 2026) among women referred to a single tertiary oncofertility center in Rome. A Delphi-informed online questionnaire was completed before the clinical visit. Descriptive statistics and exploratory multivariable logistic regression examined post-diagnosis intention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 284 women invited to participate, 260 completed the survey (response rate, 91.5%); 240 patients with a confirmed cancer diagnosis were included in the final analysis (median age, 32 years). Overall, 69.6% were interested in FP, and 94.2% recognized that gonadotoxic treatments could impair fertility. While 89.6% had heard of FP, only half received this information from healthcare professionals, and 24.2% knew of no specific options. Over half reported concerns regarding treatment delay, safety, effectiveness, and cost. Before diagnosis, 73.7% planned to have children; post-diagnosis, positive intention remained common, while those previously without intentions shifted toward uncertainty. In the 188-case model, pre-diagnosis intention showed the strongest association (OR 11.64, 95% CI 4.45\u201330.48). Given limited model performance (pseudo-R\u00b2=0.19), estimates warrant caution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this single-center referred cohort, informational gaps and uncertainty remained despite high awareness. Findings confirm and contextualize prior evidence in an Italian tertiary setting and may inform similar referral pathways, but require validation in broader populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1926475","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:25:55Z","timestamp":1791260755000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fertility preservation counselling in women with cancer: knowledge, preferences, and unmet needs from a cross-sectional survey"],"prefix":"10.3389","volume":"17","author":[{"given":"Giacomo","family":"Corrado","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Woman\u2019s and Child Health, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drieda","family":"Zace","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinic, Department of Systems Medicine, University of Rome Tor Vergata","place":["Rome, Italy"]},{"name":"Centre for Research and Studies on Procreative Health, University Department of Life Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Antoni van Leeuwenhoek-Netherlands Cancer Institute","place":["Amsterdam, Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Villa","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Woman\u2019s and Child Health, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Petrella","sequence":"additional","affiliation":[{"name":"Centre for Research and Studies on Procreative Health, University Department of Life Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]},{"name":"Local Health Authority ASST Nord Milano, S. 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Hygienic Sanitary Processes of The Territorial Center Asst Nord Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Barreca","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Woman\u2019s and Child Health, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Rome, Italy"]},{"name":"Department of Women, Mother and Neonate, \u201cVittore Buzzi\u201d Children\u2019s Hospital, University of Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Massaro","sequence":"additional","affiliation":[{"name":"Centre for Research and Studies on Procreative Health, University Department of Life Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Lafuenti","sequence":"additional","affiliation":[{"name":"Clinical Psychology Unit, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Silvestris","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori \u2018Giovanni Paolo II\u2019","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Canosa","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant Anna Hospital, University of Turin","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fabiani","sequence":"additional","affiliation":[{"name":"Regional Oncofertility Center, Sandro Pertini Hospital","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Rosaria Pia","family":"Chieffo","sequence":"additional","affiliation":[{"name":"Department of Women, Mother and Neonate, \u201cVittore Buzzi\u201d Children\u2019s Hospital, University of Milan","place":["Milan, Italy"]},{"name":"Department of Life Sciences and Public Health, Section of Gynecology and Obstetrics, Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fagotti","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Woman\u2019s and Child Health, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Rome, Italy"]},{"name":"Department of Life Sciences and Public Health, Section of Gynecology and Obstetrics, Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Centre for Research and Studies on Procreative Health, University Department of Life Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]},{"name":"Department of Life Sciences and Public Health Section of Hygiene, Fondazione Policlinico Universitario A. 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