{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:58Z","timestamp":1789535098088,"version":"build-2803163510"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    Diabetic cardiomyopathy (DCM) is a major contributor to heart failure in diabetic patients, characterized by profound metabolic remodeling and diastolic dysfunction. However, the multi-layered epitranscriptomic and post-transcriptional networks involved in this disease remain poorly understood. To address this, we established a type 2 diabetes-associated DCM mouse model using a high-fat diet (HFD) combined with low-dose streptozotocin (STZ) injections. By integrating single-molecule direct RNA sequencing (DRS-seq), chromatin accessibility profiling (ATAC-seq), and conventional bulk RNA-seq, we constructed a comprehensive epigenetic-transcriptional regulatory map of DCM. Using DRS-seq, we identified 21,156 full-length transcripts, including 8,457 (39.97%) novel unannotated isoforms, and observed a systemic 3\u2019-UTR elongation under diabetic stress. Joint ATAC-seq and DRS-seq analysis identified concurrent reductions in promoter chromatin accessibility and transcript abundance for four genes, including\n                    <jats:italic>Fam210b<\/jats:italic>\n                    (mitochondrial iron homeostasis),\n                    <jats:italic>Cdh22<\/jats:italic>\n                    (intercalated disc adhesion),\n                    <jats:italic>Fbxo10<\/jats:italic>\n                    (ubiquitin-mediated RAGE degradation), and\n                    <jats:italic>Cenpx<\/jats:italic>\n                    (DNA double-strand break repair), suggesting a potential link between altered chromatin accessibility and transcriptional regulation in DCM. Additionally, DRS-seq revealed extensive alterations in the cardiac epitranscriptome, identifying 1,719 differential m\n                    <jats:sup>6<\/jats:sup>\n                    A sites and 3,146 differential m\n                    <jats:sup>5<\/jats:sup>\n                    C sites at single-molecule resolution. Among these epitranscriptomic changes, we observed a potential post-transcriptional interplay between m\n                    <jats:sup>6<\/jats:sup>\n                    A and alternative polyadenylation (APA). Furthermore, by applying the CIBERSORT algorithm to the DRS-seq dataset, we characterized the cardiac immune microenvironment, revealing distinct pathological remodeling defined by decreased plasma cells and Th1 cells alongside a specific increase in CD4+ memory T-cell infiltration. Pearson correlation analysis showed that, among the candidate genes, only the down-regulated mitochondrial regulator\n                    <jats:italic>Fam210b<\/jats:italic>\n                    exhibited a significant negative correlation with CD4+ memory T-cell infiltration, suggesting a potential molecular association between mitochondrial dysfunction and local adaptive immune changes. Together, our study provides a high-resolution landscape of the native cardiac transcriptome and epitranscriptome, highlighting epigenetic-transcriptional coupling, m\n                    <jats:sup>6<\/jats:sup>\n                    A-APA cooperative decay, and\n                    <jats:italic>Fam210b<\/jats:italic>\n                    -associated local immune microenvironment remodeling as potential pathogenic contributor, thus offering candidate therapeutic targets for diabetic heart failure.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2026.1928778","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:35:10Z","timestamp":1789533310000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative multi-omics analysis unveils the regulatory landscape of diabetic cardiomyopathy: from chromatin accessibility to transcript isoforms and epitranscriptome"],"prefix":"10.3389","volume":"17","author":[{"given":"Licheng","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaokai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Renmin Hospital of Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichen","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.70081","article-title":"Established and emerging roles of epigenetic regulation in diabetic cardiomyopathy","volume":"41","author":"Russell-Hallinan","year":"2025","journal-title":"Diabetes Metab Res Rev"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad014","article-title":"Alternative polyadenylation regulation in cardiac development and cardiovascular disease","volume":"119","author":"Cao","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.066473","article-title":"Nanopore detection of METTL3-dependent m6A-modified mRNA reveals a new mechanism regulating cardiomyocyte mitochondrial metabolism","volume":"149","author":"Rabolli","year":"2024","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1689553","article-title":"Direct RNA sequencing reveals multilayered epitranscriptomic remodeling in macrophages upon mtb infection","volume":"15","author":"Zou","year":"2025","journal-title":"Front Cell Infect Microbiol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1261\/rna.063503.117","article-title":"The RNA modification landscape in human disease","volume":"23","author":"Jonkhout","year":"2017","journal-title":"RNA"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.908976","article-title":"m6A methylation in cardiovascular diseases: from mechanisms to therapeutic potential","volume":"13","author":"Li","year":"2022","journal-title":"Front Genet"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.933635","article-title":"Integrated bioinformatic analysis reveals immune molecular markers and potential drugs for diabetic cardiomyopathy","volume":"13","author":"Guo","year":"2022","journal-title":"Front Endocrinol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12933-025-02625-8","article-title":"Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK\/Drp1 pathway","volume":"24","author":"Niu","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol Cell"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/s41467-020-15171-6","article-title":"Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns","volume":"11","author":"Tang","year":"2020","journal-title":"Nat Commun"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.04.045","article-title":"refTSS: a reference data set for human and mouse transcription start sites","volume":"431","author":"Abugessaisa","year":"2019","journal-title":"J Mol Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1101\/gr.222976.117","article-title":"SQANTI: extensive characterization of long-read transcript sequences for quality control in full-length transcriptome identification and quantification","volume":"28","author":"Tardaguila","year":"2018","journal-title":"Genome Res"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty110","article-title":"TAPAS: tool for alternative polyadenylation site analysis","volume":"34","author":"Arefeen","year":"2018","journal-title":"Bioinformatics"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr483","article-title":"KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases","volume":"39","author":"Xie","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac039","article-title":"RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1","volume":"119","author":"Yuan","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00058.2022","article-title":"Guidelines on models of diabetic heart disease","volume":"323","author":"Heather","year":"2022","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B20","unstructured":"Highly Parallel Direct RNA Sequencing on an Array of Nanopores | Nature Methods"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1261\/rna.079623.123","article-title":"Artifacts and biases of the reverse transcription reaction in RNA sequencing","volume":"29","author":"Verwilt","year":"2023","journal-title":"RNA"},{"key":"B22","unstructured":"Nanopore Native RNA Sequencing of a Human Poly(a) Transcriptome | Nature Methods"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307082","article-title":"Genome-wide polyadenylation maps reveal dynamic mRNA 3\u2032-end formation in the failing human heart","volume":"118","author":"Creemers","year":"2016","journal-title":"Circ Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.327629","article-title":"3\u2032UTR mapping reveals alternative polyadenylation in right ventricular failure","volume":"138","author":"Neupane","year":"2026","journal-title":"Circ Res"},{"key":"B25","unstructured":"SQANTI3: Curation of Long-Read Transcriptomes for Accurate Identification of Known and Novel Isoforms | Nature Methods"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2337\/dbi23-0019","article-title":"Redefining diabetic cardiomyopathy: perturbations in substrate metabolism at the heart of its pathology","volume":"73","author":"Heather","year":"2024","journal-title":"Diabetes"},{"key":"B27","unstructured":"Multi-Dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics: Cell Metabolism"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat Methods"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002742","article-title":"FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity","volume":"293","author":"Yien","year":"2018","journal-title":"J Biol Chem"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3109\/15419061.2014.908853","article-title":"N-cadherin\/catenin complex as a master regulator of intercalated disc function","volume":"21","author":"Vite","year":"2014","journal-title":"Cell Commun Adhes"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcad047","article-title":"A novel variant of CDH2 in dilated cardiomyopathy","volume":"116","author":"Luo","year":"2023","journal-title":"QJM Mon J Assoc Physicians"},{"key":"B32","doi-asserted-by":"publisher","first-page":"114783","DOI":"10.1016\/j.celrep.2024.114783","article-title":"Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function","volume":"43","author":"Bhat","year":"2024","journal-title":"Cell Rep"},{"key":"B33","doi-asserted-by":"publisher","first-page":"7546","DOI":"10.1038\/s41598-018-25774-1","article-title":"Loss of CENP-F results in dilated cardiomyopathy with severe disruption of cardiac myocyte architecture","volume":"8","author":"Manalo","year":"2018","journal-title":"Sci Rep"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3785","article-title":"The dynamic epitranscriptome: N6-methyladenosine and gene expression control","volume":"15","author":"Meyer","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2063222","article-title":"HMGCS2 silencing attenuates high glucose-induced in vitro diabetic cardiomyopathy by increasing cell viability, and inhibiting apoptosis, inflammation, and oxidative stress","volume":"13","author":"Chen","year":"2022","journal-title":"Bioengineered"},{"key":"B36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.exphem.2022.08.002","article-title":"Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis","volume":"114","author":"Wittorf","year":"2022","journal-title":"Exp Hematol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12260","article-title":"FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1","volume":"20","author":"Watanabe","year":"2015","journal-title":"Genes Cells Devoted Mol Cell Mech"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2402063","article-title":"Noncoding RNAs and cardiac fibrosis","volume":"24","author":"Wu","year":"2023","journal-title":"Rev Cardiovasc Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"15324","DOI":"10.1038\/s41598-024-65773-z","article-title":"Identification of hub genes associated with diabetic cardiomyopathy using integrated bioinformatics analysis","volume":"14","author":"Cui","year":"2024","journal-title":"Sci Rep"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003688","article-title":"Activated T lymphocytes are essential drivers of pathological remodeling in ischemic heart failure","volume":"10","author":"Bansal","year":"2017","journal-title":"Circ Heart Fail"},{"key":"B41","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/nrm.2016.116","article-title":"Alternative polyadenylation of mRNA precursors","volume":"18","author":"Tian","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B42","unstructured":"Myocardial Fatty Acid Metabolism in Health and Disease | Physiological Reviews | American Physiological Society"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ Res"},{"key":"B44","unstructured":"Molecular Mechanisms of Diabetic Cardiomyopathy | Diabetologia | Springer Nature Link"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27062740","article-title":"Lipotoxicity in diabetic cardiomyopathy: molecular basis and emerging therapeutic targets","volume":"27","author":"Han","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s40842-025-00231-x","article-title":"The heart of diabetes: unraveling metabolic drivers of cardiomyopathy","volume":"11","author":"Guan","year":"2025","journal-title":"Cardiovasc Diabetol Endocrinol Rep"},{"key":"B47","unstructured":"Why the Diabetic Heart is Fatty | Circulation Research"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-03980-9","article-title":"A comprehensive review on diabetic cardiomyopathy (DCM): histological spectrum, diagnosis, pathogenesis, and management with conventional treatments and natural compounds","volume":"398","author":"Abdullah","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00143-22","article-title":"Elucidation of the role of FAM210B in mitochondrial metabolism and erythropoiesis","volume":"42","author":"Suzuki","year":"2022","journal-title":"Mol Cell Biol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13098-023-01135-5","article-title":"Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy","volume":"15","author":"Yan","year":"2023","journal-title":"Diabetol Metab Syndr"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13727","article-title":"FBXO10 prevents chronic unpredictable stress-induced behavioral despair and cognitive impairment through promoting RAGE degradation","volume":"27","author":"Li","year":"2021","journal-title":"CNS Neurosci Ther"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1021\/ar200057m","article-title":"Cellular dynamics of RNA modification","volume":"44","author":"Yi","year":"2011","journal-title":"Acc Chem Res"},{"key":"B53","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1261\/rna.072785.119","article-title":"Direct RNA sequencing enables m6A detection in endogenous transcript isoforms at base-specific resolution","volume":"26","author":"Lorenz","year":"2020","journal-title":"RNA"},{"key":"B54","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s12026-025-09702-w","article-title":"METTL14 aggravates pyroptosis in diabetic cardiomyopathy by promoting m6A modification of NLRP3","volume":"73","author":"Hua","year":"2025","journal-title":"Immunol Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.freeradbiomed.2026.03.006","article-title":"WTAP-regulated m6A modification contributes to cuproptosis in cardiomyocytes and diabetic cardiomyopathy","volume":"249","author":"Jia","year":"2026","journal-title":"Free Radic Biol Med"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2026.117860","article-title":"YTHDF2 alleviates diabetic cardiomyopathy by targeting m6A-mediated degradation of lncRNA RMRP and inhibiting NLRP3-dependent pyroptosis","volume":"248","author":"Xu","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.7150\/thno.104441","article-title":"Nsun2 controls cardiac homeostasis and hypertrophic response by regulating PRKACA expression","volume":"15","author":"Jian","year":"2025","journal-title":"Theranostics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.yjmcc.2025.09.009","article-title":"Myofibroblast specific knockdown of NSUN2 suppresses cardiac fibrosis post-myocardial infarction","volume":"209","author":"Sun","year":"2025","journal-title":"J Mol Cell Cardiol"},{"key":"B59","unstructured":"IGF2BP2 Binding to CPSF6 Facilitates M6a-Mediated Alternative Polyadenylation of PUM2 and Promotes Malignant Progression in Ovarian Cancer - Luo - 2025 - Clinical and Translational Medicine - Wiley Online Library"},{"key":"B60","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12943-019-1065-4","article-title":"METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer","volume":"18","author":"Yue","year":"2019","journal-title":"Mol Cancer"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1349409","article-title":"Advances in the role of the GADD45 family in neurodevelopmental, neurodegenerative, and neuropsychiatric disorders","volume":"18","author":"Huang","year":"2024","journal-title":"Front Neurosci"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.12.018","article-title":"FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling","volume":"15","author":"Zechner","year":"2012","journal-title":"Cell Metab"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.07.027","article-title":"Depletion of T lymphocytes ameliorates cardiac fibrosis in streptozotocin-induced diabetic cardiomyopathy","volume":"39","author":"Abdullah","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1542208","article-title":"The immunology of diabetic cardiomyopathy","volume":"16","author":"Song","year":"2025","journal-title":"Front Endocrinol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002225","article-title":"Left ventricular T-cell recruitment contributes to the pathogenesis of heart failure","volume":"8","author":"Nevers","year":"2015","journal-title":"Circ Heart Fail"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/nature10992","article-title":"Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure","volume":"485","author":"Oka","year":"2012","journal-title":"Nature"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central memory and effector memory T cell subsets: function, generation, and maintenance","volume":"22","author":"Sallusto","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa069","article-title":"T lymphocyte subsets associated with prevalent diabetes in veterans with and without human immunodeficiency virus","volume":"222","author":"Bailin","year":"2020","journal-title":"J Infect Dis"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137253","article-title":"Deletion of the mitochondrial membrane protein Fam210b is associated with the development of systemic lupus erythematosus","volume":"25","author":"Xu","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B70","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41419-025-07375-9","article-title":"FAM210B activates STAT1\/IRF9\/IFIT3 axis by upregulating IFN-\u03b1\/\u03b2 expression to impede the progression of lung adenocarcinoma","volume":"16","author":"Gao","year":"2025","journal-title":"Cell Death Dis"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1928778\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:35:30Z","timestamp":1789533330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1928778\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":70,"alternative-id":["10.3389\/fendo.2026.1928778"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1928778","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"article-number":"1928778"}}