{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:18:10Z","timestamp":1787894290548,"version":"build-2784847793"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated gamma-glutamyltransferase (GGT), a marker of oxidative stress and cardiometabolic burden, and reduced estimated glomerular filtration rate (eGFR) are each linked to arterial stiffness, but they are usually examined separately. This study evaluated whether a single index integrating both\u2014the GGT\u2013eGFR composite index\u2014is associated with brachial-ankle pulse wave velocity (baPWV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross-sectional analysis of 893 adults from a Japanese health check-up program. The composite index was calculated as ln(GGT) \u00d7 100\/eGFR. Its association with baPWV (continuous) and with elevated baPWV (\u22651400 and \u22651600 cm\/s) was assessed using multivariable linear and logistic regression, restricted cubic splines, joint GGT\u00d7eGFR stratification, subgroup analyses, and sensitivity analyses. Models containing the composite index were also compared with models containing ln(GGT), eGFR, or both components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>baPWV increased across index quartiles (1295 to 1531 cm\/s). In the fully adjusted model, each 1-SD increment in the index was associated with a 20.46 cm\/s higher baPWV (95% CI 5.64\u201335.28; P\u00a0=\u00a00.007); the highest versus lowest quartile difference was 74.77 cm\/s (95% CI 33.96\u2013115.57; P&amp;lt;0.001). The index was also associated with baPWV \u22651400 cm\/s (OR 1.32, 95% CI 1.06\u20131.64) and \u22651600 cm\/s (OR 1.36, 95% CI 1.04\u20131.79). Direct model comparisons showed a modest improvement in model fit for continuous baPWV after inclusion of the composite index, while categorical model performance was broadly comparable across models. Restricted cubic spline analysis showed an overall association with baPWV (P for overall = 0.011), with no statistically significant evidence of departure from linearity (P for non-linearity = 0.192). The association was consistent across sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cross-sectional secondary analysis, a higher exploratory GGT\u2013eGFR-derived index remained associated with higher baPWV after multivariable adjustment. Direct comparison with ln(GGT) and eGFR showed only modest differences in model fit, and prospective external validation is required before clinical application can be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1930792","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:32:48Z","timestamp":1787891568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The gamma-glutamyltransferase-to-estimated glomerular filtration rate composite index is associated with arterial stiffness: a cross-sectional secondary analysis of a health check-up population"],"prefix":"10.3389","volume":"17","author":[{"given":"Tengfei","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Fuwai Central China Cardiovascular Hospital, Henan Cardiovascular Disease Center (Central China Subcenter of National Center for Cardiovascular 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Fuwai Central China Cardiovascular Hospital, Henan Cardiovascular Disease Center (Central China Subcenter of National Center for Cardiovascular Diseases), Central China Fuwai Hospital of Zhengzhou University, Henan Provincial Cardiovascular Hospital","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziniu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Fuwai Central China Cardiovascular Hospital, Henan Cardiovascular Disease Center (Central China Subcenter of National Center for Cardiovascular Diseases), Central China Fuwai Hospital of Zhengzhou University, Henan Provincial Cardiovascular Hospital","place":["Zhengzhou, 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