{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:01:44Z","timestamp":1790226104705,"version":"4.1.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To prospectively observe changes in periodontal clinical outcomes and local and blood-derived inflammatory markers among patients with periodontitis with and without type 2 diabetes following routine scaling and root planing (SRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational cohort study consecutively enrolled patients with periodontitis and classified them according to pre-existing diabetes status. SRP was provided as part of routine clinical care and was not assigned or modified by the investigators; no untreated concurrent comparison group was included. Periodontal clinical parameters, gingival crevicular fluid levels of TNF-\u03b1, IL-1\u03b2, and IL-10, and peripheral blood-derived NLR and SII were assessed at baseline and approximately 3 months. HbA1c was additionally evaluated as an exploratory outcome in participants with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 3 months, PD, BI, and PLI were significantly lower than baseline in both groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05), whereas CAL did not change significantly. BI remained higher in the diabetes-associated periodontitis group than in the non-diabetic periodontitis group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.039). Gingival crevicular fluid TNF-\u03b1 decreased significantly in both groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001) but remained higher in the diabetes-associated periodontitis group at 3 months (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). IL-1\u03b2 did not change significantly in either group. IL-10 increased significantly in the non-diabetic periodontitis group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05), whereas the increase in the diabetes-associated periodontitis group was not significant. NLR and SII decreased significantly in both groups, with no significant between-group differences at baseline, 3 months, or in the magnitude of change. In participants with diabetes, HbA1c showed a non-significant numerical decrease from 8.37 \u00b1 1.03% to 8.07 \u00b1 1.06% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.081).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients receiving routine SRP, periodontal clinical parameters and selected inflammatory markers improved over the 3-month follow-up in both groups. Participants with diabetes had higher residual local inflammation at 3 months, reflected by higher BI and gingival crevicular fluid TNF-\u03b1 levels, whereas no significant between-group differences in changes in blood-derived inflammatory indices were detected. HbA1c decreased numerically but not significantly; therefore, no conclusion regarding improved glycemic control can be drawn.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1937181","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:31:31Z","timestamp":1790224291000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and inflammatory changes following routine scaling and root planing in periodontitis patients with and without diabetes: a prospective observational cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, the Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital)","place":["Zhengzhou, 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, the Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital)","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, the Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital)","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, the Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital)","place":["Zhengzhou, 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